POEMS Syndrome

Treatment

Although POEMS syndrome is rare, Mayo Clinic doctors see many people with this disease each year. Treatment for POEMS syndrome depends on its stage and severity. A multispecialty team of doctors at Mayo Clinic combines their expertise to develop the appropriate treatment plan for your needs. Your treatment team may recommend one or more of the following treatment options.

• Chemotherapy. When abnormal plasma cells are widespread, your doctor may recommend chemotherapy.
• Peripheral blood stem cell transplant. Mayo Clinic doctors have special expertise in performing a peripheral blood stem cell transplant, using stem cells collected directly from blood, to treat POEMS syndrome. For some people, high-dose chemotherapy is given to destroy abnormal cells followed by peripheral blood stem cell transplantation.
• Corticosteroids. These powerful anti-inflammatory drugs help subdue your body's immune response and produce extra bone marrow cells.
• Radiation therapy. At Mayo Clinic, you have access to the most advanced radiation therapy treatment.

Other treatments

• Intensive supportive care measures. These measures are designed to help manage and relieve symptoms of the disease. Therapies may include pain medication, medications to reduce fluid retention, foot care, and safety measures to compensate for loss of sensation or weakness.
• Physical therapy. Your doctor may recommend physical therapy, with the possible addition of braces or walking aids, to increase your mobility if you have a disability caused by weakening of feet, legs, hands and arms (neuropathy).
• Hormone replacement. If you're experiencing hormonal abnormalities, your doctor may develop a customized hormone replacement plan for you.