Permanent Prostate Brachytherapy

Research

Researchers at Mayo Clinic are studying imaging techniques to improve permanent prostate brachytherapy. The effectiveness of permanent prostate brachytherapy depends upon the correct distribution of the radioactive seeds. Current imaging methods are unable to consistently view all seeds during the procedure. Computed tomography (CT) is accurate but not usually possible until after the procedure.

One such imaging technique, called vibro-acoustography, has 3-D imaging capability and is particularly sensitive to hard objects. These qualities make vibro-acoustography an ideal imaging method for brachytherapy seed placement and position assessment and correction — all in one procedure. Researchers at Mayo Clinic have conducted vibro-acoustography tests on human tissue that produced clear, 3-D images of the prostate within a few minutes.

Publications

Davis BJ, Brinkmann DH, Kruse JJ, Herman MG, LaJoie WN, Schwartz DJ, Pisansky TM, Kline RW. Selective identification of different brachytherapy sources, ferromagnetic seeds and fiducials in the prostate using an automated seed sorting algorithm. Brachytherapy 2004;3(2); 106-112. [Abstract]

Solhjem MC, Davis BJ, Pisansky TM, Wilson TM, Mynderse LA, Herman MG, King BF, Geyer SM. Prostate volume measurement by trans-rectal ultrasound and computed tomography before and after permanent prostate brachytherapy: implications for intraoperative dosimetry using image fusion. Int J Radiat Oncol Biol Phys. 60(3):767-776; 2004. [Abstract]

Su Y, Davis BJ, Herman MG, Robb RA. Prostate brachytherapy seed localization by analysis of multiple fluoroscopic projections: identifying and addressing the seed overlap problem. Med Phys 2004; 31: 1277-1287. [Abstract]

Eshleman JS, Davis BJ, Pisansky TM, Wilson TM, Haddock MG, King BF, Darby CH, LaJoie WN, Oberg AL. Radioactive seed migration to the chest following transperineal interstitial permanent prostate brachytherapy: extraprostatic seed placement correlates with migration. Int J Radiat Oncol Biol Phys: 59(2):419-425: 2004. [Abstract]

Wehle, MJ. Lisson, SW. Buskirk, SJ. Broderick, GA. Young, PR. Igel, TC. Prediction of genitourinary tract morbidity after brachytherapy for prostate adenocarcinoma. [Article] Mayo Clinic Proceedings 2004 Mar;79(3):314-7.

Davis BJ, Kinnick RR, Fatemi M, Lief EP, Robb RA, Greenleaf JF. Measurement of the ultrasound backscatter signal from three seed types as a function of incidence angle: application to permanent prostate brachytherapy. Int J Radiat Oncol Biol Phys. 57(4):1174-1182; 2003. [Abstract]

Schwartz DJ, Davis BJ, Vetter RJ, Pisansky TM, Herman MG, Wilson TM, LaJoie WN, Oberg AL. Radiation exposure to operating room personnel during transperineal interstitial permanent prostate brachytherapy. Brachytherapy. 2003;2(2)98-102. [Abstract]

Holmes DR III, Davis BJ, Bruce CJ, Robb RA. 3D visualization, analysis, and treatment of the prostate using trans-urethral ultrasound. Comput Med Imaging Graph. 2003;27(5), 339-349. [Abstract]

Davis BJ, Pisansky TM, Leibovich BC. Adjuvant external radiation therapy following radical prostatectomy for node-negative prostate cancer. Curr Opin Urol. 2003;13(2):117-122. [Abstract]

Pisansky TM, Blute ML, Hillman DW, Davis BJ, Haddock MG, Suman VJ, Wilson TM, Zincke H. The relevance of prostatectomy findings in brachytherapy selection for localized prostate cancer. Cancer. 2002; 95:513-519. [Abstract]

Holmes DR 3rd. Davis BJ. Robb RA. 3D localization of implanted radioactive sources in the prostate using trans-urethral ultrasound. Stud Health Technol Inform. 2001; 81:199-205. [Abstract]

Leibovich BC, Blute ML, Bostwick DG, Wilson TM, Pisansky TM, Davis BJ, Ramnani DM, Cheng L, Sebo TJ, Zincke H. Proximity of prostate cancer to the urethra: implications for minimally invasive ablative therapies. Urology. 2000; 56(5):726-729. [Abstract]

Davis BJ, Haddock MG, Wilson TM, Rothenberg HJ, Bostwick DG, Herman MG, Pisansky TM. Treatment of extraprostatic cancer in clinically organ confined prostate cancer by permanent interstitial brachytherapy: Is extraprostatic seed placement necessary? Tech Urol. 2000; 6:70-77. [Abstract]

Davis BJ, Pisansky TM, Wilson TM, Rothenberg HJ, Pacelli A, Hillman DW, Sargent DJ, Bostwick DG. The radial distance of extraprostatic extension of prostate cancer: implications for prostate brachytherapy. Cancer.1999; 85:2630-37. [Abstract]

Garces, YI. Buskirk, SJ. Serago, CF. Karstaedt, N. Knudsen, JM. Casale, HE. Igel, TC. Wehle, MJ. Computed tomography vs magnetic resonance imaging in post-implant analysis of transperineal interstitial permanent prostate brachytherapy. (Abstract 10-P). [Abstract] Journal of Brachytherapy International 1999 Apr;15(2):141.

Stieber, VW. Buskirk, SJ. Serago, CF. Blobe, TA. Igel, TC. Wehle, MJ. A change in prostate volume after brachytherapy does not translate to a change in target coverage. (Abstract 26-P). [Abstract] Journal of Brachytherapy International 1999 Apr;15(2):146.