Pancreatic Cancer

Research

Mayo Clinic physicians and scientists collaborate with others throughout the United States to identify genes that are relevant to the development of pancreatic cancer. A large research study is being conducted by the Pancreatic Cancer Genetic Epidemiology (PACGENE) Consortium and is funded by the National Cancer Institute. Mayo Clinic is actively involved in PACGENE, as well as in pancreatic cancer research.

In addition, Mayo Clinic physicians are leading trials that investigate the combination of radiation therapy and chemotherapy for patients who cannot undergo surgical resection and for patients whose cancer has spread beyond the pancreas. For patients who can undergo resection, postoperative radiation and chemotherapy are recommended, and clinical trials are investigating the best combination of chemotherapy drugs and radiation.

Publications

Fletcher JG, Wiersema MJ, Farrell MA, Fidler JL, Burgart LJ, Koyama T, Johnson CD, Stephens DH, Ward EM, Harmsen WS. Pancreatic malignancy: value of arterial, pancreatic, and hepatic phase imaging with multi-detector row CT. Radiology. 2003 Oct;229(1):81-90. [Abstract]

Fidler JL, Fletcher JG, Reading CC, Andrews JC, Thompson GB, Grant CS, Service FJ. Preoperative detection of pancreatic insulinomas on multiphasic helical CT. AJR Am J Roentgenol. 2003 Sep;181(3):775-80. [Abstract]

Petersen GM, Hruban RH. Pancreatic cancer: where are we in 2003? J Natl Cancer Inst. 2003 Feb 5;95(3):180-1. [Abstract]

Klein AP, Beaty TH, Bailey-Wilson JE, Brune KA, Hruban RH, Petersen GM. Evidence for a major gene influencing risk of pancreatic cancer. Genet Epidemiol. 2002 Aug;23(2):133-49. [Abstract]

Murphy KM, Brune KA, Griffin C, Sollenberger JE, Petersen GM, Bansal R, Hruban RH, Kern SE. Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%. Cancer Res. 2002 Jul 1;62(13):3789-93. [Abstract]

Pongprasobchai S, Chari ST. Management of Patients at High Risk for Pancreatic Cancer. Curr Treat Options Gastroenterol. 2003 Oct;6(5):349-358. [Abstract]