Ophthalmology in Minnesota

Research

The Department of Ophthalmology is involved in several aspects of research: national multicenter studies, clinical studies conducted at Mayo and basic science research.

We wish to acknowledge the annual support of our research programs by the Research to Prevent Blindness organization, www.rpbusa.org.

National Multicenter Studies

• Collaborative Ocular Melanoma Study
• Ocular Hypertension Treatment Study
• Congenital Esotropia Observational Study
• Alpha Interferon Therapy for Multiple Sclerosis
• Amblyopia Treatment Study
• Transpupillary Thermotherapy for Subfoveal Occult Choroidal Neovascularization in Age-Related Macular Degeneration
• Complications of Age-Related Macular Degeneration Prevention Trial (CAPT)
• A phase I/II Multi-Center Study for the Safety, Tolerability, Pharmacokinetics, and Activity of Multiple-Dose Intravitreal Injections of rhuFabV2 in Subjects with Neovascular Age-Related Macular Degeneration

Clinical Studies Conducted at Mayo Clinic

Cornea and External Disease

• Epidemiology of Cataract Surgery and Complications of Cataract Surgery
• Outcomes of Keratoprothesis Surgery
• Corneal Transplantation: Long-term Follow up
• Measurement of Corneal Endothelial Function
• Keratocyte Density After Photorefractive Keratectomy or LASIK Using Confocal Microscopy in Vivo
• Measurement of Keratocyte Density With Confocal Microscopy in Vivo in Contact Lens Wearers, Corneal Transplants and Eyes With Keratoconus
• Phacoemulsification and the Hearing Impaired

Glaucoma

• Estimation of the Risk of Blindness from Newly Diagnosed and Treated Open Angle Glaucoma
• Risk Factors for Progression to Blindness in Open Angle Glaucoma
• The Risk of Filtration Surgery in Open Angle Glaucoma
• Intermediate Follow-up of Mitomycin C and Non-Mitomycin C Trabeculectomies
• A Retrospective Population Based Study of Pigmentary Dispersion and Pigmentary Glaucoma
• Exfoliation Syndrome and Systemic Vascular Disease

Oculoplastics and Orbital Disease

• Orbital Radiotherapy for Graves' Ophthalmopathy (Thyroid Eye Disease)
• MRI Characteristics in Graves' Ophthalmopathy
• Epidemiology of Essential Blepharospasm
• Epidemiology of Malignant Eyelid Tumors
• Long-term Follow-up of Myectomy for Essential Blepharospasm
• Long-term Follow-up of Necrobiotic Xanthogranuloma
• Ophthalmic Manifestations of Cutaneous T-Cell Lymphoma
• Surgical Therapy of Blepharoptosis in Myasthenia Gravis
• Radiation Induced Meningiomas

Neuro-ophthalmology

• Giant Cell Arteritis Study
• Pupillary Responses to Pilocarpine
• Diplopia Associated with Temporal Lobectomy

Pediatric Ophthalmology and Strabismus

• Testing Vision in Infants and Young Children
• Compliance in Amblyopia Treatment
• Chronic Sixth Nerve Palsy Outcome Study

Retina and Vitreous

• Rochester Diabetic Retinopathy Study
• Pancreas Transplant Study in Diabetics and the Effects on Retinopathy
• Epidemiology of Diabetes Interventions and Complications
• A Clinical Trial in Overt Nephropathy
• The Effects on Zopolrestat on Diabetic Retinopathy
• Transpupillary Thermotherapy in The Treatment of Small Ocular Melanomas
• Transpupillary Thermotherapy for Subfoveal Occult Choroidal Neovascularization in Age-Related Macular Degeneration
• Complications of Age-Related Macular Degeneration Prevention Trial (CAPT)
• A phase I/II Multi-Center Study for the Safety, Tolerability, Pharmacokinetics, and Activity of Multiple-Dose Intravitreal Injections of rhuFabV2 in Subjects with Neovascular Age-Related Macular Degeneration

Basic Science Research

• Pharmacology of Drugs for Glaucoma
• Confocal Imaging of the Cornea
• Non-invasive Measures of Ocular Physiology
• Intraocular Pressure Monitoring by Telemetry
• Corneal Preservation
• Corneal Ion Channel Research
• Organ Culture in Glaucoma Research
• Retinopathy of Prematurity (ROP) Research