Non-Hodgkin Lymphoma

Research

The principal goal of lymphoma research at Mayo is to develop novel biologic therapies for non-Hodgkin lymphoma. To achieve this goal, Mayo researchers are identifying promising target molecules that are overexpressed in lymphoma cells and developing methods to inhibit the pathways they support. Additionally, they are exploring methods to activate and augment the lymphoma-specific host immune response. These strategies are being tested in preclinical models and then being used clinically in early phase clinical trials. Various correlative laboratory studies are being done in conjunction with these studies to determine the biologic effect of these therapies on the malignant cells and the regional immune cells. A further area of research is epidemiologic studies that define patients' genetic factors that may predispose them to developing lymphoma.

Publications:

Holtan SG, Porrata LF, Micallef IN, Padley DJ, Inwards DJ, Ansell SA, Johnston PB, Gastineau DA, Markovic SN. AMD3100 affects autograft lymphocyte collection and progression-free survival after autologous stem cell transplantation in non-Hodgkin lymphoma. Clin Lymphoma Myeloma. 2007 Jan;7(4):315-8. [Abstract]

Siddiqui M, Ristow K, Markovic SN, Witzig TE, Habermann TM, Colgan JP, Inwards DJ, White WL, Ansell SM, Micallef IN, Johnston PB, Call TG, Porrata LF. Absolute lymphocyte count predicts overall survival in follicular lymphomas. Br J Haematol. 2006 Sep;134(6):596-601. Epub 2006 Aug 1. [Abstract]

Holtan SG, Porrata LF, Inwards DJ, Ansell SM, Micallef IN, Johnston PB, Litzow MR, Gastineau DA, Markovic SN. Timing of autologous stem cell transplantation from last chemotherapy affects lymphocyte collection and survival in non-Hodgkin lymphoma. Br J Haematol. 2006 Jun;133(6):628-33. [Abstract]

Buadi FK, Micallef IN, Ansell SM, Porrata LF, Dispenzieri A, Elliot MA, Gastineau DA, Gertz MA, Lacy MQ, Litzow MR, Tefferi A, Inwards DJ. Autologous hematopoietic stem cell transplantation for older patients with relapsed non-Hodgkin's lymphoma. Bone Marrow Transplant. 2006 Jun;37(11):1017-22. [Abstract]

Joao C, Porrata LF, Inwards DJ, Ansell SM, Micallef IN, Johnston PB, Gastineau DA, Markovic SN. Early lymphocyte recovery after autologous stem cell transplantation predicts superior survival in mantle-cell lymphoma. Bone Marrow Transplant. 2006 May;37(9):865-71. [Abstract]

Ghobrial IM, Weenig RH, Pittlekow MR, Qu G, Kurtin PJ, Ristow K, Ansell SM. Clinical outcome of patients with subcutaneous panniculitis-like T-cell lymphoma. Leuk Lymphoma. 2005 May;46(5):703-8. [Abstract]

Nowakowski GS, Dewald GW, Hoyer JD, Paternoster SF, Stockero KJ, Fink SR, Smoley SA, Remstein ED, Phyliky RL, Call TG, Shanafelt TD, Kay NE, Zent CS. Interphase fluorescence in situ hybridization with an IGH probe is important in the evaluation of patients with a clinical diagnosis of chronic lymphocytic leukaemia. Br J Haematol. 2005 Jul;130(1):36-42. [Abstract]

Olivier KR, Brown PD, Stafford SL, Ansell SM, Martenson JA Jr. Efficacy and treatment-related toxicity of radiotherapy for early-stage primary non-Hodgkin lymphoma of the parotid gland. Int J Radiat Oncol Biol Phys. 2004 Dec 1;60(5):1510-4. [Abstract]

Vachon CM, Habermann TM, Kurtin PJ, Cerhan JR. Clinical characteristics of familial vs. sporadic non-Hodgkin lymphoma in patients diagnosed at the Mayo Clinic (1986-2000). Leuk Lymphoma. 2004 May;45(5):929-35. [Abstract]

Ghobrial IM, Wolf RC, Pereira DL, Fonseca R, White WL, Colgan JP, Habermann TM, Inwards DJ, Markovic SN, Ansell SM, Micallef IN, Porrata LF, Witzig TE. Therapeutic options in patients with lymphoma and severe liver dysfunction. Mayo Clin Proc. 2004 Feb;79(2):169-75. [Abstract]

Yip CC, Bartley GB, Habermann TM, Garrity JA. Involvement of the lacrimal drainage system by leukemia or lymphoma. Ophthal Plast Reconstr Surg. 2002 Jul;18(4):242-6. [Abstract]

Bouwhuis SA, el-Azhary RA, McEvoy MT, Gibson LE, Habermann TM, Witzig TE, Pittelkow MR. Treatment of late-stage Sezary syndrome with 2-Chlorodeoxyadenosine. Int J Dermatol. 2002 Jun;41(6):352-6. [Abstract]

Wong WW, Schild SE, Halyard MY, Schomberg PJ. Primary non-Hodgkin lymphoma of the breast: The Mayo Clinic Experience. J Surg Oncol. 2002 May;80(1):19-25; discussion 26. Review. [Abstract]

Lim JK, Lacy MQ, Kurtin PJ, Kyle RA, Gertz MA. Pulmonary marginal zone lymphoma of MALT type as a cause of localised pulmonary amyloidosis. J Clin Pathol. 2001 Aug;54(8):642-6. [Abstract]

Porrata LF, Gertz MA, Inwards DJ, Litzow MR, Lacy MQ, Tefferi A, Gastineau DA, Dispenzieri A, Ansell SM, Micallef IN, Geyer SM, Markovic SN. Early lymphocyte recovery predicts superior survival after autologous hematopoietic stem cell transplantation in multiple myeloma or non-Hodgkin lymphoma. Blood. 2001 Aug 1;98(3):579-85. [Abstract]

Phan TG, O'Neill BP, Kurtin PJ. Posttransplant primary CNS lymphoma. Neuro-oncol. 2000 Oct;2(4):229-38. [Abstract]