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Mayo Clinic Clinical Update e-Edition
September 2013
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An individualized model for cancer treatment

This may be the most transformational time in medicine. Over the last decade, we have developed the ability to sequence the human genome rapidly and cost-effectively. Genomic sequencing, in combination with pharmacogenomics, epigenomics and microbiome studies, may increase our understanding of existing cancer, more accurately predict cancer development, and expand our knowledge of potential responses to drugs and other treatments.

These discoveries point to a more individualized medical model. This issue of the Cancer Physician Update e-Edition is devoted to personalized medicine, to capture both the opportunities and the challenges of the groundbreaking new technologies.

Patient Care

IM Clinic offers genomic consulting for cancer, diagnostic odyssey cases

Mayo's enterprisewide Individualized Medicine (IM) Clinic integrates advances in genomic science and gene sequencing into clinical practice. The clinic currently offers consulting for intractable cancers and diagnostic odyssey cases.

Molecular maps help tailor specific drug therapy for patients with lung cancer

Genomic analysis through profiling can help inform clinical decision-making for patients with various lung cancer subtypes in whom mutation status may warrant different treatment approaches.

Lynch syndrome screening underutilized

Despite studies showing the efficacy of Lynch syndrome screening and the availability of next-generation sequencing to evaluate for germline mutations, only a handful of centers routinely test for the disease.

Research

NGS opens door to genetic testing for complex diseases
Next-generation sequencing (NGS) can help identify genetic contributors to complex diseases, including cancer. It's hoped this will lead to individualized prognosis, diagnosis and treatments for polygenic disorders.

International collaborations identify remaining genetic risk factors for breast cancer
Innovative research combines family history data with laboratory techniques to develop models that consider specific environmental and genetic influences to determine women's individualized, rather than averaged, risk of breast cancer.

Stool DNA test promising for IBD cancer surveillance
A new study finds methylation markers are highly accurate for detecting colorectal neoplasia in patients with inflammatory bowel disease (IBD). Modeled on a stool DNA test for sporadic colorectal cancer, the test is noninvasive and requires no bowel prep.

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Education

Individualizing Medicine 2013: From Promise to Practice
Sept. 29-Oct. 2, 2013, in Rochester, Minn.
Topics include integration of drug-gene pair alerts into the EMR, understanding which patients may benefit from whole-genome and whole-exome sequencing interpretation and relevance to prognosis and diagnosis, sharing complicated genomic information with patients, and discussion of regulatory, legal and bioethical issues.

Mayo Clinic Acute and Chronic Leukemias 2013: A Case-Based Discussion
Sept. 14, 2013, in Phoenix
This course focuses on current and evolving therapy for chronic myeloid malignancies, acute myeloid leukemia and acute lymphoid leukemia, plus practical leukemia management.

Hematologic Malignancies: New Therapies and the Evolving Role of Transplant
Oct. 11-12, 2013, in Chicago
Discover new therapies in treating patients with hematologic malignancies, the evolving role of blood and marrow transplantation (BMT) in these therapies, new methodologies related to BMT and how to best provide long-term follow-up for these patients.

See all Hematology & Oncology Continuous Professional Development courses

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Grand Rounds

Center for Individualized Medicine improves patient care through genomic-based methodologies
Konstantinos N. Lazaridis, M.D., provides an overview of the individualized medicine clinic at Mayo Clinic. Its mission: to discover and integrate the latest in genomic and clinical sciences into personalized care for each Mayo Clinic patient and beyond.

Mayo Clinic Cancer Center begins 39th year of National Cancer Institute funding
Robert B. Diasio, M.D., provides an overview of the Mayo Clinic Cancer Center, its progress over the past five years, preparation for 2013 Cancer Center Support Grant renewal and vision for the future.

New Grand Rounds presentations are available online

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New Staff

Sameer R. Keole, M.D.
Radiation Oncology in Arizona

Wei Liu, Ph.D.
Radiation Oncology in Arizona

Aaron S. Mansfield, M.D.
Oncology in Minnesota

Michelle A. Neben Wittich, M.D.
Radiation Oncology in Minnesota

Sara W. Reder, M.D.
Hematology/Oncology in Arizona

Jiajian (Jason) Shen, Ph.D.
Radiation Oncology in Arizona

Saravut (John) J. Weroha, M.D., Ph.D.
Oncology in Minnesota

Consults & Referrals

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Resources

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