Dendrimers deliver corticosteroids to the retina to target inflammation-causing cells
Researchers found that polyamidoamine dendrimers — flexible, microscopic particles of repetitively branched molecules — have an intrinsic ability to selectively localize in activated microglia and can deliver drugs inside these cells for a sustained period for the treatment of retinal neuroinflammation.
Children with congenital esotropia are more likely to develop mental illness
Rochester Epidemiology Project research indicates that children diagnosed with CET are more likely to have mental illness diagnoses by their third decade and use psychotropic medications. They are also more likely to have been born prematurely.
Age-related cataract surgery rates increase to record levels
Rochester Epidemiology Project research confirms increasing cataract incidence rates addressed via improved access to surgery, an increase in the number of surgeons, a shift from hospital-based to outpatient surgery and the adoption of widening indications for surgery, including second-eye surgery.
Cancer immunotherapy cures tumor-burdened mice
Researchers used human DNA from melanoma cells delivered through the vector vesicular stomatitis virus to eradicate cancerous tumors in mice. Success is associated with the ability of mouse lymphoid cells to mount a tumor-specific recall response in vitro.
TSH receptor antagonists impact orbital fibroblast functions relevant to GO development
No uniformly effective therapy exists for Graves' ophthalmology. Insights into the important role of TSH receptor and TRAb in the development of the tissue remodeling characteristic of the disease suggest new approaches to therapy.