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Mayo Clinic Digestive Diseases Physician Update e-Edition
June 2013
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Toward a more individualized medical model

This may be the most transformational time in medicine. Over the last decade, we have developed the ability to sequence the human genome rapidly and cost-effectively. Genomic sequencing, in combination with pharmacogenomics, epigenomics and microbiome studies, may increase our understanding of existing disease, more accurately predict disease development, and expand our knowledge of potential responses to drugs and other treatments.

All of this is leading toward a more individualized medical model. That is why we are devoting this issue of the newsletter to personalized medicine. Our aim is to capture both the opportunities and the challenges of the groundbreaking new technologies.

Patient Care

Targeted IBD therapies not yet ready for primetime

More genomic regions and genes have been identified for inflammatory bowel disease (IBD) than for most other complex disorders. The abundance of genetic data both strengthens and complicates the search for targeted IBD agents.

Lynch syndrome screening underutilized

Despite studies showing the efficacy of Lynch syndrome screening and the availability of next-generation sequencing to evaluate for germline mutations, only a handful of centers routinely test for the disease.


Stool DNA test promising for IBD cancer surveillance
A new study finds methylation markers are highly accurate for detecting colorectal neoplasia in patients with inflammatory bowel disease (IBD). Modeled on a stool DNA test for sporadic colorectal cancer, the test is noninvasive and requires no bowel prep.

NGS opens door to genetic testing for complex diseases
Next-generation sequencing (NGS) can help identify genetic contributors to complex diseases, including cancer. It's hoped this will lead to individualized prognosis, diagnosis and treatments for polygenic disorders.

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10th Annual Course: 2013 Mayo Clinic EUS Summit and Principles and Pearls in Pancreatology

July 31-Aug. 3, 2013, in Rochester, Minn.
This course gives health care providers at all experience levels a comprehensive, multidisciplinary review of endoscopic ultrasound. Experts from gastroenterology, hepatology, radiology and endosonography will discuss the impact and role of EUS in their practice.

Mayo Clinic Gastroenterology and Hepatology Board Review

Sept. 5-8, 2013, in Chicago
Designed for candidates preparing for certification or maintenance of certification examinations in gastroenterology, this course will include topics such as pathology, endoscopy, radiology and nutrition.

Individualizing Medicine 2013: From Promise to Practice

Sept. 30-Oct. 2, 2013, in Rochester, Minn.
This conference helps physicians and other health care providers understand the latest developments in genomics and applications for integrating them into clinical practice. It features expert speakers, focused breakout sessions, a poster session, case studies and opportunities for discussion.

Mayo Clinic Gastroenterology & Hepatology 2014

March 13-16, 2014, in Orlando, Fla.
Designed for physicians and other health care providers in gastroenterology and hepatology, this course discusses new approaches to the diagnosis and management of gastrointestinal and liver diseases.

See all Gastroenterology Continuous Professional Development courses

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Grand Rounds

New Grand Rounds presentations are available online

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Consults & Referrals

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