Neurology

The Amyotrophic Lateral Sclerosis (ALS) Clinic provides expert, comprehensive care for people with ALS and related neuromuscular conditions.

Each year, Mayo Clinic cares for more than 1,200 people with ALS. Mayo Clinic campuses in Arizona, Florida and Minnesota are designated Certified Treatment Centers of Excellence by the ALS Association.

ALS can be difficult to diagnose in its early stages because symptoms may be similar to those of other conditions. Mayo Clinic specialists use advanced tests to confirm your diagnosis. Genetic testing may help identify inherited forms of ALS.

The ALS Clinic offers a range of services to help manage symptoms, maintain function and support quality of life.

A diagnosis of ALS can feel overwhelming. You may have many questions about what comes next. Your care team at the ALS Clinic supports you as your condition changes and helps guide your care.

Your care team

Your care is led by neurologists with specialized training in ALS and other neuromuscular conditions. They work closely with a team of specialists.

Your team may include:

• Pulmonologists.
• Physical medicine and rehabilitation specialists, called physiatrists.
• Palliative care specialists.
• Physical and occupational therapists.
• Speech therapists.
• Respiratory therapists.
• Genetic counselors.
• Dietitians.
• Social workers.
• Nurses.

Together, your team shares results quickly, talks with you about your care options and coordinates your visits and tests to help reduce delays.

Personalized treatment

Your care team works with you to create a care plan based on your health needs and goals. You may receive physical and occupational therapy to help maintain mobility and function. Ongoing care may include support for breathing, nutrition guidance if swallowing becomes difficult, and therapies or devices to help with speech and communication.

Your care plan is reviewed regularly and adjusted as your needs change.

Social workers help with care planning, access to resources and coping with the challenges of ALS. Support groups are available for you and your family.

Conditions and symptoms treated

• Amyotrophic lateral sclerosis (ALS).
• Bulbar and pseudobulbar palsy.
• Familial ALS.
• Fasciculations.
• Kennedy disease, also called spinobulbar atrophy.
• Localized motor neuron diseases.
• Motor neuron disease.
• Motor neuropathies.
• Multifocal motor neuropathy.
• Post-polio syndrome.
• Primary lateral sclerosis (PLS).
• Spinal muscular atrophy.

ALS research and clinical trials

Mayo Clinic physician-scientists and researchers study the causes, genetics and potential therapies for amyotrophic lateral sclerosis (ALS) and related diseases. This research helps improve how ALS is diagnosed and treated.

You may have the option to take part in clinical trials or other research studies as part of your care at Mayo Clinic.

Learn more about Mayo Clinic research in neuromuscular diseases and ALS.

Nationally recognized expertise

Mayo Clinic in Rochester, Minnesota, Mayo Clinic in Phoenix/Scottsdale, Arizona, and Mayo Clinic in Jacksonville, Florida, rank among the Best Hospitals for neurology and neurosurgery in the U.S. News & World Report Best Hospitals rankings. Mayo Clinic Children's in Rochester is ranked the No. 1 hospital in Minnesota and the five-state region of Iowa, Minnesota, North Dakota, South Dakota and Wisconsin, according to U.S. News & World Report's 2025-2026 "Best Children's Hospitals" rankings.

Mayo Clinic is ranked more than any other hospital and has been recognized as an Honor Roll member according to the U.S. News & World Report's "Best Hospitals" rankings.