Nephrogenic systemic fibrosis is an uncommon disease that seems to occur exclusively in people with chronic kidney disease or kidney failure. The disease causes extensive patches of thickened and hardened skin. Nephrogenic systemic fibrosis can also affect internal organs such as the heart and lungs and can cause a disabling shortening of muscles and tendons in the joints (joint contracture). Being exposed to gadolinium-containing contrast agents during MRI testing has been identified as a significant risk factor for development of this disease.
Mayo Clinic in Rochester, Minn., and Mayo Clinic in Scottsdale, Ariz., are ranked among the Best Hospitals for kidney disorders by U.S. News & World Report. Mayo Clinic in Jacksonville, Fla., is ranked high performing for kidney disorders by U.S. News & World Report.