Myelofibrosis

Symptoms

Symptoms of myelofibrosis with myeloid metaplasia depend on the type of blood cell affected. Problems with red blood cells may cause symptoms of anemia, such as shortness of breath and fatigue. Decreases in the white blood cell count can depress the immune system and increase risks of infection. Decreases in platelets can lead to bleeding. Patients may develop enlarged spleens (splenomegaly) from the leukemialike cells produced by marrow that accumulates in the body. Patients can also experience fatigue, night sweats, weight loss and bone pain.