Changes in bone reabsorption markers

Changes in the bone resorption markers, urinary deoxypyridinoline (Dpd), and N-telopeptide of type I collagen (NTx) in men who were artificially deficient in testosterone (T) and estrogen (E) and for whom the replacement was neither hormone (T, E), E alone (T, +E), T alone (+T, E) or both (+T, +E). E alone was able to largely prevent (by ~70%) the increase in bone resorption present in the T, E group, whereas T alone (in the absence of aromatization to E) was much less effective. * indicates P<.05, ** indicates P<.005, and *** indicates P<.001 vs baseline. Error bars indicate standard error of the mean. Adapted from Drs. Falahati-Nini A, et al. "Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men." The Journal of Clinical Investigation. 2000;106:1553. Adapted with permission.