Test of blood-brain barrier integrity in mouse pretreated with bevacizumab plus injection of fluorescein

Testing the integrity of the blood-brain barrier (BBB) in the Mayo Clinic xenograft model. Micrograph shows a pathological mouse brain section with tumor (outlined in white) in a mouse pretreated with bevacizumab. Penetration of the BBB with injection of fluorescein showed significantly less BBB penetration in a mouse pretreated with bevacizumab.