Survival probability in the MADIT-CRT trial. The diagnosis of heart failure, which was made by physicians who were aware of study group assignments, required signs and symptoms consistent with CHF that was responsive to intravenous decongestive therapy on an outpatient basis or an augmented decongestive regimen with oral or parenteral medications during an in-hospital stay. EF represents ejection fraction; ICD, implantable cardioverter-defibrillator; CRT, cardiac resynchronization therapy; CRT-D, cardiac resynchronization therapy defibrillator; NYHA, New York Heart Association. Adapted, with permission, from Moss et al, N Engl J Med 2009;361:1333.