Liver Transplant

Clinical Trials

Below is a list of Liver Transplant clinical trials from the clinical trials database at Mayo Clinic.

This list includes only trials about which Mayo researchers choose to publish information. Mayo Clinic may be conducting other trials which are not in this database. Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

Calcinerin Inhibitors and the Drug Cozaar in Liver Transplant Recipients
This research study is being done to determine the pathogenesis of chronic renal dysfunction in patients undergoing liver transplantation. To study the changes in renal function and renal morphology in patients on calcineurin inhibitors following OLT and the effect of losartan, an angiotention II receptor blocker, on renal function and morphology in patients on calcineurin inhibitors following liver transplantation.
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Efficacy and Safety of a Long Term Calcineurin Inhibitor Free Maintenance Regimen with Mycophenolate Mofetil and Sirolimus in Recipients of an Orthotopic Liver Transplant
This study is being done to compare three different immunosuppressive medications- sirolimus (Rapamune), cyclosporin (Neoral, Gengraf), and tacrolimus (Prograf) when used in combination with a standard immunosuppressive dose of mycophenolate mofetil (CellCept).

The study is looking at safety, effects (good and bad) and the ability to preserve kidney function. Currently CellCept, tacrolimus, and cyclosporine are approved by the FDA for use in the prevention of organ rejection in liver transplant patients, when used in specific combinations with other agents. Not all the combinations allowed in the study are FDA approved but they are in common use.

This study is being done in liver transplant recipients to compare sirolimus (Rapamune), cyclosporin (Neoral, Gengraf), and tacrolimus (Prograf) when used in combination with a standard immunosuppressive dose of mycophenolate mofetil (CellCept).
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