Laboratory Genetics in Minnesota

2004 Publications from the Cytogenetics Laboratory

Full Publications
Abstracts
Book Chapters

The following 2004 peer reviewed publications were produced by the Cytogenetics Laboratory and illustrate most of the areas that we have been investigating. As a laboratory, we published 30 papers, 51 abstracts, and 4 book chapters during 2004. The total career bibliography of the five laboratory directors combined totals 679 peer reviewed publications, 784 abstracts, 56 book chapters and 3 books that involve a wide variety of cytogenetic investigations.

Full Publications

Adem C, Jenkins RB, Capron F. High-risk lesions I high-risk women: A high-risk formalin-based biology. JCO:1159-1161, 2004.

Adem C, Soderberg CL, Hafner K, Reynolds C, Slezak JM, Sinclair CS, Sellers, TA, Schaid DJ, Couch F, Hartmann LC, Jenkins RB. ERBB2, TBX2, RPS6KB1, and MYC alterations in breast tissues of BRCA1 and BRCA2 mutation carriers. Genes Chromosomes Cancer 41:1-11, 2004.

Adeyinka A, Stockero KJ, Flynn HC, Lorentz CP, Ketterling RP, Jalal SM. Familial 22q11.2 deletions in DiGeorge/velocardiofacial syndrome are predominantly smaller than the commonly observed 3Mb. Genet Med 6:517-520, 2004.

Aldape KD, Ballman K, Furth A, Buckner JC, Schaefer PL, Giannini C, Burger PC, Scheithauer BW, Jenkins RB, James CD. Immunohistochemical detection of EGFRvIII in malignancy grade astrocytomas and evaluation of prognostic significance. J Neuropathol Exp Neurol, 63:700-707, 2004.

Asamoah A, Nwankwo M, Kumar SP, Ezhuthachan SG, Van Dyke DL. Proximal chromosome 8q deletion in a boy with femoral bifurcation and other multiple congenital anomalies. Am J Med Genet 15:127A(1):65-68, 2004.

Babovic-Vuksanovic D, Jenkins SC, Ensenauer R, Newman DC, Jalal SM. Subtelomeric deletion of 18p in an adult with paranoid schizophrenia and mental retardation. Am J Med Genet 124A:318-322, 2004.

Baker D, Jegsnathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, Kumar R, Jenkins RB, de Groen PC, Roche P, van Deursen JM. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nature Genet 36:744-749, 2004.

Coon SW, Savera AT, Benninger MS, Zarbo RJ, Chase GA, Rybicki BA, Van Dyke DL. Prognostic implications of loss of heterozygosity at 8p21 and 9p21 in head and neck squamous cell carcinoma. Int J Cancer 111:206-212, 2004.

Ensenauer R, Jalal SM, Meyer R, Babovic-Vuksanovic D. Unbalanced cryptic 5p deletion/17p duplication identified by FISH in a family with a boy with chimerism and a balanced t(4;5). Am J Med Genet 125A:86-91, 2004.

Erickson LA, Jalal SM, Harwood A, Shearer B, Jin L, Lloyd RV. Analysis of parathyroid neoplasms by interphase fluorescence in situ hybridization. Am J Surg Pathol 28(5):548-584, 2004.

Greenberg PL, Lee SJ, Advani R, Tallman MS, Sikic BI., Letendre L; Dugan K; Lum B; Chin DL, Dewald G, Paietta E, Bennett JM, Rowe JM. Mitoxantrone, etoposide, and cytarabine with or without valspodar in patients with relapsed or refractory acute myeloid leukemia and high-risk myelodysplastic syndrome: a phase III trial (E2995). Journal of Clinical Oncology 22:1078-1086, 2004.

Greipp PT, Dewald GW, Tefferi A. Prevalence, breakpoint distribution, and clinical correlates of t(5;12). Cancer Genet Cytogenet 153:170-172, 2004.

Hildebrandt MAT, Salavaggione OE, Martin YN, Flynn HC, Jalal SM, Wieben ED, Weinshilboum RM. Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies. Biochem Biophys Res Commun 321:870-878, 2004.

Ireland JW, Jalal SM, McGrann PS, Lindor NM. Nonmosaic smallest duplication of 12q24.31-qter: The first reported case. Amer J Med Genet 128A:305-310, 2004.

Kebriaei P, Winter JN, Laport GG, Le Beau MM, Dewald G, Larson RA. Multiple unrelated clonal abnormalities in host bone marrow cells after allogeneic stem cell transplantation. Leuk Res 28: 537-540, 2004.

Kuriakose P, Perveen N, Maeda K, Wiktor A, Van Dyke DL. t(8;14)(q24;q32) as the sole cytogenetic abnormality in B-cell prolymphocytic leukemia. Cancer Genet Cytogenet 150:156-158, 2004.

Mahaffey VJ, Spurbeck JL, Carlson RO, Dewald GW. Hematologic malignancies, critical genes and representative pictures for 166 chromosome anomalies. Leuk Res 28:1351-1356, 2004.

Paietta E, Ferrando AA, Neuberg D, Bennett JM, Racevskis J, Lazarus H, Dewald G, Rowe JM, Wiernik PH, Tallman, MS, Look AT. Activating FLT3 mutations in CD117/KIT(+) T-cell acute lymphoblastic leukemias. Blood 104: 558-560, 2004.

Paietta E, Goloubeva O, Neuberg D, Bennett JM, Gallagher R, Racevskis J, Dewald G, Wiernik PH, Tallman MS, Eastern Cooperative Oncology Group. A surrogate marker profile for PML/RARA expressing acute promyelocytic leukemia and the association of immunophenotypic markers with morphologic and molecular subtypes. Cytometry 59B:1-9, 2004.

Pardanani A, Brockman SR, Paternoster SF, Flynn HC, Ketterling RP, Lasho TL, Ho CL, Li CY, Dewald GW, A. Tefferi A: FIP1L1-PDGFRA fusion. Prevalence and clinicopathologic correlates in 89 consecutive patients with moderate to severe eosinophilia.Blood 104: 3038-45, 2004.

Raitanen M, Worsham MJ, Lakkala T, Carey TE, van Dongen G, Van Dyke DL, Grenman R, Klemi P, Rantenen V, Isola J, Grenman S. Characterization of 10 vulvar carcinoma cell lines by karyotyping, comparative genomic hybridization, and flow cytometry. Gynecol Oncol 93:155-163, 2004.

Remstein ED, Kurtin PJ, Einerson RR, Paternoster SF, Dewald GW. Primary pulmonary MALT lymphomas show frequent and heterogeneous cytogenetic abnormalities, including aneuploidy and translocations involving API2 and MALT1 and IGH and MALT1. Leukemia 18: 156-60, 2004.

Rowe JM, Neuberg D, Friedenberg W, Bennett JM, Paietta E, Makary AZ, Liesveld JL, Abboud CN, Dewald G, Hayes FA, Tallman MS, Wiernik PH. A phase 3 study of three induction regimens and of priming with GM-CSF in older adults with acute myeloid leukemia: a trial by the Eastern Cooperative Oncology Group. Blood 103: 479 – 485, 2004.

Salama ME, Shah V, Lebel RR, Van Dyke DL. Aberrant nuclear projections of neutrophils in trisomy 13. Arch Pathol 128:243-244, 2004.

Smoley SA, Brockman SR, Paternoster SF, Meyer RG, Dewald GW: A novel tricolor, dual-fusion fluorescence in situ hybridization method to detect BCR/ABL fusion in cells with t(9;22)(q34;q11.2) associated with deletion of DNA on the derivative chromosome 9 in chronic myelocytic leukemia. Cancer Genet Cytogenet 148: 1-6, 2004.

Spurbeck JL, Adams, SA, Stupca P, Dewald GW: Primer on medical genomics Part XI: Visualizing human chromosomes. Mayo Clin Proc 79: 58-75, 2004.

Tallman MS, Kim HT, Paietta E, Bennett JM, Dewald G, Cassileth PA, Wiernik PH, Rowe JM; Eastern Cooperative Oncology group: Acute monocytic leukemia (French-American-British classification M5) does not have a worse prognosis than other subtypes of acute myeloid leukemia: a report from the Eastern Cooperative Oncology Group. J of Clin Oncol 22: 1276-1286, 2004.

Wiktor A, Van Dyke DL. Combined cytogenetic testing and FISH analysis in the study of chronic lymphocytic leukemia and multiple myeloma. Cancer Genet Cytogenet 153:73-76, 2004.

Wiktor A, Van Dyke DL. FISH analysis helps identify low level mosaicism in Ullrich-Turner syndrome patients. Genet Med 6(3):132-135, 2004.

Zhang Y, Emmanuel N, Kamboj G, Chen J, Shurafa M, Van Dyke DL, Wiktor A, Rowley JD. PRDX4, a member of the peroxiredoxin family, is fused to AML1 (RNUX1) in an acute myeloid leukemia patient with a t(X;21)(p22;q22). Genes Chromosomes Cancer 40:365-370, 2004.

Abstracts

Adeyinka A, Brimmer T, Thorland EC, Adams SA, Jalal SM. Delineation of 1p36 deletion sizes using a panel of FISH probes. Poster presentation. American Society of Human Genetics Annual Meeting, Toronto, 2004.

Adeyinka A, Thorland EC, Adams SA, Dawson BD, Jalal SM. Deletions involving 1p36: Incidence and categories among 8723 patients analyzed by G-banding and 2257 patients analyzed by subtelomeric FISH probe. American College of Medical Genetics Annual Meeting, Orlando, 2004.

Babovic-Vuksanovic D, Mensink KA, Heese BA, Spinner RJ, Ketterling RP, Knudson RA, Gilmer HF, Lindor NM. Connective tissue dysplasia in two new patients with NF1 microdeletions: further expansion of phenotype. Abstract 10281. ASHG 2004.

Cairncross G, Seiferheld W, Shaw E, Jenkins R, Scheithauer B, Brachman D, Buckner J, Fink K, Souhami L, Curran W: An intergroup Randomized Controlled Clinical Trial (RCT) of Chemotherapy plus Radiotherapy (RT) versus RT alone fro pure anaplastic and mixed anaplastic oligodendroglioma: Initial report of RTOG 94-02. (ASCO, 2004 Meeting).

Call TG, Constantinou CL, Kahanic SP, Rowland KM, Dakil SR, Hoering A, Li CY, Dewald GW, Kay NE, Witzig TE. NCCTG Trial of Gemcitabine for Relapsed B-Cell Chronic Lymphocytic Leukemia. 2004 Annual Meeting of the American Society of Clinical Oncology. June 5 – 8, 2004, New Orleans, Louisiana, USA. Abstract 3746.

Dewald G. The Ph-chromosome does not preferentially involve specific chromosomes of any one parental gender. Questions and Answers. CAP Today 18: 81, 2004.

Dingli D, Arora B, Sirhan S, Dewald GW, Ayalew T. Prognostic Diversity of Cytogenetic Lesions in Myelofibrosis with Myeloid Metaplasia: A Prospective Study of 88 Patients. Session Type: Poster Session 662-I. 46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Poster presentation 132-II. Blood 104: 2004. [1508]

Fink S, Geyer S, Shanafelt T, Smoley S, Paternoster S, Giordano K, Tschumper R, Jelinek, D, Bone N, Kabat B, Call T, Phyliky R, Kay N, Dewald G. Clinical Significance of Homozygous D13S319 Deletion in B-cell Chronic Lymphocytic Leukemia (B-CLL). 46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Poster Session 69-III. Blood 104: 2004. [2799]

Flinn IW, Kumm E, Grever MR, Neuberg, Dewald GW, Bennett JM, Paietta EM, Appelbaum FR, Larson RA, Hussein MA, Moore DF, Tallman MS. Eastern Cooperative Oncology Group, (ECOG); Cancer and Leukemia Group B; Southwest Oncology Group. Fludarabine and Cyclophosphamide Produces a Higher Complete Response Rate and More Durable Remissions Than Fludarabine in Patients with Previously Untreated CLL: Intergroup Trial E2997. Session Type: Oral Session. 46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Blood 104: 2004. [475]

Flynn HC, Knudson RA, Shearer BM, Ketterling RP. Development of a highly sensitive FISH assay to detect TEL/AML1 fusion associated with t(12;21)(p13;q22) in pediatric patients with precursor B-cell acute lymphoblastic leukemia. Association for Molecular Pathology, November 2004.

Galanis E, Buckner JC, Maurer M, Ballman K, Hidalgo M, Kreisberg J, Boni J, James CD, Jenkins R, Walser DJ: NCCTG Phase II study of CCI-779 in patients (pts) with Recurrent Glioblastoma Multiforme GBM. (ASCO, 2004 Meeting)

Ghoshal MK, Majumder S, Kutay H, Neuberg DS, Kitada S, Reed JC, Dewald GW, Flinn IW, Appelbaum FR, Larson RA, Tallman MS, Liu T, Plass C, Lucas DM, Byrd JC, Jacob ST, Grever MR. Methylation of the Tumor Suppressor Gene PTPRO (Receptor-Type Protein Tyrosine Phosphatase) Is Associated with Expression of Important Apoptosis-Related Proteins in Chronic Lymphocytic Leukemia (CLL). Session Type: Poster Session 74-III. 46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Platform presentation. Blood 104: 2004.

Grever M, Lucas DM, Dewald GW, Neuberg DS, Flinn IW, Appelbaum FR, Larson RA, Tallman MS, Gribben JG, Byrd JC. Outcome of Treatment with Fludarabine Versus Fludarabine and Cyclophosphamide in Chronic Lymphocytic Leukemia (CLL) Is Adversely Impacted by High Risk Genetic Features: Results from ECOG 2997. Session Type: Poster Session 757-III. 46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Platform presentation. Blood 104: 2004. [3487]

Grogg KL, Ketterling RP, Kurtin PJ, Macon WR, Knudson RA, Remstein ED. Diagnostic utility of fluorescence in situ hybridization detection of cytogenetic abnormalities in paraffin-embedded angioimmunoblastic T cell lymphoma. Abstract 451213. United States and Canadian Academy of Pathology Annual Meeting, Vancouver, British Columbia, Canada, March 3-6, 2004.

Haddad TC, Shanafelt TD, Slager L, Phyliky RL, Zent CS, Dewald GW, Kay NE, Call TG. Familial Chronic Lymphocytic Leukemia (CLL): The Mayo Clinic Experience. Session Type: Poster Session 119-II. 46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Poster presentation. Blood 104: 2004. [1906]

James CL, Adams SA, Lorentz CP, VanDeWalker TJ, Malin S, Toriello H, Jalal SM, Ketterling RP. A family with multiple chromosome abnormalities involving both parents. 29 th Annual Meeting of the Association of Genetic Technologists, Anaheim, California, June 17-20, 2004.

James CL, Stupca PJ, Dewald GW. Quality system thinking – a useful tool to monitor quality and operational functions in the laboratory. Proceedings of the Annual Meeting of the Association for Genetic Technologists. Anaheim, California, June 17-20, 2004. Abstract A2, page 289.

Jenkins RB, Kollemeyer T, Buckner K, Bamlet W, Ballman KV, Yang P: A polymorphism in GLTSCR1 is associated with the development of oligodendrogliomas. (AACR, 2004 Meeting)

Kay NE, Geyer SM, Lin T, Call TG, Jelinek DF, Bone ND, Dewald GW, Heerema NL, Tschumper R, Smith L, M. Grever, Byrd JC. Combination Chemotherapy with Pentostatin, Cyclophosphamide and Rituximab Induces High Rate of Remissions Including Complete Responses and Achievement of Minimal Residual Disease in Previously Untreated B-Chronic Lymphocytic Leukemia. Session Type: Oral Session. 46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Platform presentation. Blood 104: 2004. [339]

Ketterling RP, Knudson RA, Flynn Gilmer HC. Discovery of 6 novel translocations involving the Imatinib responsive genes PDGFRA and PDGFRB from screening 29,047 abnormal bone marrow specimens. American Society of Hematology 46 th Annual Meeting, San Diego, California, December 4-7, 2004.

Kitada S, Reed JC, Lucas DM, Neuberg DS, Gribben JG, Dewald GW, Flinn IW, Appelbaum FR, Larson RA, Tallman MS, Byrd JC, Grever MR. Critical Molecular Studies to Strategically Plan Therapy in Chronic Lymphocytic Leukemia (CLL): Correlating Cellular Proteins with Defined Prognostic Patient Subsets and Their Response to Treatment. Session Type: Poster Session 110-I. 46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Poster presentation 132-II. Blood 104: 2004. [956]

Knight MZ, Shearer BM, Ketterling RP, Halling KC. Prevalence of t(6;9)(p23;q34)/DEK-CAN gene fusion in patients with acute myelogenous leukemia (AML) carrying a FLT3 mutation. Abstract 451113. United States and Canadian Academy of Pathology Annual Meeting, Vancouver, British Columbia, Canada, March 3-6, 2004.

Knudson RA, Shearer BM, Flynn-Gilmer HC, Ketterling RP. Development of a combined cytoplasmic immunoglobulin (cIg) immunostaining and FISH method to specifically analyze plasma cells for the common chromosome anomalies observed in myeloma patients. Association for Molecular Pathology, November 2004.

Kollmeyer TM, Yang P, Buckner K, Bamlet W, Ballman KV, Jenkins RB: A polymorphism in GLTSCR1 is associated with the development of oligodendrogliomas. (SNO, 2004 Meeting).

Krogness AG, Knudson RA, Rowsell EH, Ketterling RP. Co-expression of two specific primary chromosomal translocations t(15;17)(q22;q21) and t(8;21)(q22;q22) in a patient with acute myeloid leukemia. 29 th Annual Meeting of the Association of Genetic Technologists, Anaheim, California, June 17-20, 2004.

Lee YK, Fink S, Therneau T, Smoley S, Paternoster, Adeyinka A, Larson D, Fonseca R, Kyle R, Dewald G. Survival Based on Metaphase Versus Interphase Cells for 154 Patients with Newly Diagnosed Multiple Myeloma. 46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Poster presentation. Blood 104: 2004. [1422]

Lewis JT, Ketterling RP, Macon WR. t(2;17)(q31-34;q21) is another recurrent chromosomal abnormality in hepatosplenic T cell lymphomas. Abstract 450209. United States and Canadian Academy of Pathology Annual Meeting, Vancouver, British Columbia, Canada, March 3-6, 2004.

Lucas DM, Dewald GW, Neuberg DS, Byrd JC, Lozanski G, Harbison J, Cunningham KD, Flinn IW, Appelbaum FR, Larson RA, Tallman MS, Grever MR. Clinical, Laboratory, and Treatment Outcome Characteristics of Chronic Lymphocytic Leukemia (CLL) Patients with p53 Mutations or del(17p) Enrolled on a Prospective Phase III Clinical Trial: Short Progression Free Survival, Irrespective of Fludarabine-Based Treatment Used. Session Type: Poster Session 103-I.46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Blood 104: 2004. [949]

Mahaffey VJ, Spurbeck JL, Carlson RO, Dewald GW: Hematologic malignancies, critical genes and representative pictures for 166 chromosome anomalies. Proceedings of the Annual Meeting of the Association for Genetic Technologists. Anaheim, California, June 17-20, 2004. Abstract A3, page 290.

Meyer RG, Ketterling RP. AML1 gene amplification in pediatric acute lymphoblastic leukemia: report of 3 cases. 29 th Annual Meeting of the Association of Genetic Technologists, Anaheim, California, June 17-20, 2004.

Miller DV, Jenkins RB, Lingle EL, Davidson PA, Kaufman S, Martino S, Dakhil SR, Perez EA: Focal HER2/neu amplified clones partially account for discordance between immunohistochemistry and fluorescence in-situ hybridization results: Data from NCCTG N9831 intergroup adjuvant trial. (ASCO, 2004 Meeting)

Miller KB, Kim HT, Greenberg P, van der Jagt R, Bennett JM, Tallman MS, Paietta E, Dewald G, Houston JG, Thomas M, Rowe J. Leukemia Committee, Eastern Cooperative Oncology Group, Brookline MA,; Leukemia Committee, Canadian Leukemia Study Group, Ottawa ON:Phase III Prospective Randomized Trial of EPO with or without G-CSF Versus Supportive Therapy Alone in the Treatment of Myelodysplastic Syndromes (MDS): Results of the ECOG- CLSG Trial (E1996). Session Type: Oral Session.46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Blood 104: 2004. [70]

Nowakowski GS, Dewald GW, Paternoster SF, Fink SR, Smoley SA, Remstein ED, Hoyer JD, Phyliky RL, Call TG, Shanafelt TD, Zent, CS. Interphase Fluorescence In Situ Hybridization (FISH) with an IgH Probe is Important in the Management of Patients with a Clinical Diagnosis of Chronic Lymphocytic Leukemia (CLL). 46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Poster presentation 132-II. Blood 104: 2004. [1919]

Perez EA, Suman VJ, Davidson NE, Martino S, Kaufman PA, Lingle WL, Flynn PJ, Ingle JN, Visscher D, Jenkins RB: HER2 testing by local, central, and reference laboratories in the NCCTG N9831 intergroup adjuvant trial. (ASCO, 2004 Meeting)

Puck SM, Blitzer MG, Toriello HV, Van Dyke DL, Watson MS, Williams MS. Development of disease specific codes for genetic disorders. Ann Clin Genet Meeting, March 4-7, 2004.

Remstein ED, Kurtin PJ, Einerson RR, Paternoster SF, Brockman SR, Dewald GW.Extranodal Marginal Zone B-Cell Lymphomas of Mucosa Associated Lymphoid Tissue (MALT lymphomas) Contain Heterogeneous Chromosome Translocations That Result in Fusion of API2-MALT1, IGH-MALT1, IGH-BCL10, and IGH-BCL6, as Well as Translocations Involving IGH and Other Partner Genes. United States Canadian Academy of Pathologists, annual meeting. Vancouver British Columbia. March 2004.

Roberson J, Van Dyke D, Wiktor A. Mental retardation, hyperphagia and obesity due to inherited 22q13.33 deletion. American Society of Human Genetics Annual Meeting, Toronto, October 26-30, 2004. Amer J Hum Genet A925, 2004.

Rush PW, Quigg MH, Refuerzo JS, Roberson JR, Das S, Van Dyke DL. Prenatal diagnosis of paternal uniparental disomy 14. Ann Clin Genet Meeting, March 4-7, 2004.

Shaw EG, Seiferheld W, Cairncross JG, Jenkins R, Scheithauer B, Brachman D, Buckner J, Fink K, Souhami L, Curran W: Radiation therapy (RT) alone vs intensive procarbazine-CCNU-vincristine (I-PCV) chemotherapy followed by radiation therapy for anaplastic oligodendroglioma (AO) and mixed oligo-astrocytoma (MOA): Results of radiation therapy oncology group (RTOG) – intergroup protocol 94-02. (ASTRO, 2004 Meeting).

Shearer BM, Knudson RA, Flynn-Gilmer HC, Ketterling RP. Development of a highly sensitive FISH assay to detect rpn1-evi1 fusion associated with inv(3)(q21q26) or t(3;3)(q21;q26) in acute myelogenous leukemia. Association for Molecular Pathology, November 2004.

Slovak ML, Bloomfield CD, Gundacker H, Dewald G, Appelbaum FR, Larson RA, Tallman MS, Willman C, Ravindranath Y, Alonzo TA, Carroll A, Hirsch B, Raimondi S, Heerema NA: Acute Myeloid Leukemia (AML) With t(6;9)(p23;q34) Defines A Very Poor Risk Leukemia Subgroup With Distinguishing Clinicopathological Features: A United States (US) Cytogenetics Intergroup Study Of 62 AML and MDS Cases. 46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Platform presentation. Blood 104: 2004. [567]

Smoley SA, Flynn HC, Shearer BM, Ketterling RP. Development of a highly sensitive D-FISH assay for diagnosis and minimal residual disease detection of Inv(16)(p13.1q22) or t(16;16)(p13.1;q22) in patients with acute myelogenous leukemia. 29 th Annual Meeting of the Association of Genetic Technologists, Anaheim, California, June 17-20, 2004.

Stockero KJ, Adeyinka A, Flynn HC, Lorentz CP, Kuffel DG, Ketterling RP, Dawson DB, Jalal SM. Smaller Size of 22q11.2 microdeletion has a significant risk of familial transmission in DiGeorge/velocardiofacial syndrome. Association of Genetic Technologists Annual Meeting, Anaheim, 2004.

Tallman M, Dewald G, Lazarus H, Gandham S, Nelson G, Logan B, Rowe J, Litzow M, Keating A, Mehta J, Wetzler M, Warren T, Weisdorf D. Impact of Cytogenetics on Outcome of Mismatched Unrelated Donor Hematopoietic Stem Cell Transplantation for Adults with AML. Session Type: Oral Session. 46th Annual Meeting of American Society of Hematology. San Diego, CA. December 2004. Platform presentation. Blood 104: 2004.

Templeton KL, Law ME, Misra A, Feuerstein BG, Jenkins RB: Mapping of common 1p36 deletion region using glioma cell lines. (SNO, 2004 Meeting).

Tessler Drewianka K, Stupca P, Flynn Gilmer H, Smoley S, Mahaffey VJ, Hogan WJ, Ketterling RP. Atypical CML with subtle t(9;12)(q34;p13) and ABL/TEL gene fusion. 29 th Annual Meeting of the Association of Genetic Technologists, Anaheim, California, June 17-20, 2004.

Thorland EC, Ireland JW, Adeyinka A, Courteau LK, Dawson BD, Babovic-Vuksanovic D, Jalal SM. A non-standard deletion in a patient with Prader-Willi syndrome: Implications for FISH-based diagnostic strategies. American College of Medical Genetics Annual Meeting, Orlando, 2004.

Thorland EC, Ireland JW, Courteau LK, Dawson DB, Babovic-Vuksanovic D, Jalal SM. Cloning breakpoints of an uncommon deletion in a patient with Prader-Willi syndrome. Platform presentation. Platform presentation. American Society of Human Genetics Annual Meeting, Toronto, 2004.

Van Dyke DL, Ebrahim SA, Al Saadi A, Powell SA, Zenger-Hain JL. The effect of maternal serum screening programs on trisomy 21 prenatal and postnatal diagnosis in southeast Michigan. Ann Clin Genet Meeting, March 4-7, 2004.

Van Dyke DL , Wiktor A. The use of culture mitogens in B-cell disorders. American Society of Human Genetics Annual Meeting, Toronto, October 26-30, 2004.

Welch RA, Wiktor A, Van Dyke DL, Blessed WB: Obstetrician-gynecologists performing genetic amniocentesis may be misleading themselves and the genetics laboratory. Central Assoc Obstet Gynecol. 2004.

Book Chapters

Dewald GW, Brockman SR, Paternoster SF. Molecular cytogenetic studies for hematological malignancies. In: Finn WG, Peterson LC., Hematopathology in Oncology. Kluwer Academic Publications, pp 69-112, 2004.

Enns RK, Dewald GW, Barker PE, Rasmussen DJ, Watson M, Wood G, Wyatt PR. NCCLS. Fluorescence in situ hybridization (FISH) methods for medical genetics; approved guideline. NCCLS document MM7-A [ISBN 1-56238-524-0]. NCCLS, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898, 2004.

Jalal SM, Adeyinka A, Thornhill A. Chromosome analysis in prenatal diagnosis. In, Handbook of Clinical Laboratory Testing During Pregnancy. (A.M. Gronowski, ed). Humana Press, USA, Totowa NJ, pp. 139-157, 2004.

Jalal SM, Ketterling RP. Euchromatic Variants. In, Atlas of Human Chromosome Heteromorphisms, (H.E. Wyandt, V.S. Tonk, eds) Kluwer Academic Press, New York, p 75-86, 2004