Laboratory Genetics in Minnesota

2003 Publications from the Cytogenetics Laboratory

Original Articles
Reviews and Chapters

The following 2003 peer reviewed publications were produced by the Cytogenetics Laboratory and illustrate most of the areas that we have been investigating. As a laboratory, we published 28 papers, 34 abstracts, and 3 book chapters during 2003. The total career bibliography of the four laboratory directors combined totals 524 peer reviewed publications, 527 abstracts, 39 book chapters and 2 books that involve a wide variety of cytogenetic investigations.

Original Articles

Adem C, Reynolds C, Soderberg CL, Slezak JM, McDonnell SK, Sebo TJ, Schaid DJ, Myers JL, Sellers TA, Hartmann LC, Jenkins RB. Pathologic characteristics of breast parenchyma in patients with hereditary breast carcinoma, including BRCA1 and BRCA2 mutation carriers. Cancer 97:1-11, 2003.

Adem C, Reynolds C, Soderberg CL, Sebo TJ, Cunningham JM, Thibodeau SN, Hartmann LC, Jenkins RB. Microsatellite instability in hereditary and sporadic breast cancers. Int J Cancer 107:580-582, 2003.

Brockman SR, Paternoster SF, Ketterling RP, Dewald GW. New Highly Sensitive Fluorescence In Situ Hybridization Method to Detect PML/RARα Fusion in Acute Promyelocytic Leukemia. Cancer Genet Cytogenet 145: 144-151, 2003.

Buckner JC, Gesme D Jr, O’Fallon JR, Hammack JE, Stafford S, Brown PD, Hawkins R, Scheithauer BW, Erickson BJ, Levitt R, Shaw EG, Jenkins R. Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: Efficacy and associations with chromosomal abnormalities. J Clin Oncol 21:251-255, 2003.

Chen Y-C, Chou J-M, Ketterling RP, Letendre L, Li C-Y. Histologic and immunohistochemical study of bone marrow monocytic nodules in 21 cases with myelodysplasia. Am J Clin Pathol 120(6)874-881, 2003.

Cherry AM, Brockman SR, Paternoster SF, Hicks GA, Higgins RR, Bennett JM, Greenberg PL, Miller K, Rowe J, Tallman MS, Dewald GW. Comparison of interphase FISH and metaphase cytogenetics to study myelodysplasia: an Eastern Cooperative Oncology Group (ECOG) study. Leukemia Research 27: 1085-1090, 2003.

Debes-Marun CS, Dewald GW, Bryant S, Picken E, Santana-Dávila R, González-Paz N, Kyle RA, Gertz MA, Witzig TE, Dispenzieri A, Lacy MQ, Rajkumar SV, Lust JA, Greipp PR, Fonseca R. Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma. Leukemia 17: 427-36, 2003.

Dewald GW, Brockman SR, Paternoster SF, Bone ND, O’Fallon JR, Allmer CA, James CD, Jelinek DF, Tschumper RC, Hanson CA, Pruthi RK, Witzig TE, Kay NE. Chromosome anomalies detected by interphase FISH: correlation with significant biological features of B-cell chronic lymphocytic leukemia. British Journal of Haematology 121: 287-295, 2003.

Dewald GW. Molecular cytogenetic studies are changing the care of patients with hematological malignancies. The Korean Journal of Hematology 38: 31-45, 2003.

Ensenauer R, Jalal SM, Meyer R, Babovic-Vuksanovic D. Unbalanced cryptic 5p deletion/17p duplication identified by FISH in a family with a boy with chimerism and balanced t(4;5). Am J Med Genet. On line Aug. 2003.

Ensenauer RE, Adeyinka A , Flynn HC, Michels VV, Lindor NM, Dawson DB, Thorland EC, Pham Lorentz C, Goldstein JL, McDonald MT, Smith WE, Simon-Fayard E, Alexander AA, Kulharya AS, Ketterling RP, Clark RD, Jalal SM. Microduplication 22q11.2, an emerging syndrome: Clinical, cytogenetic and molecular analysis of thirteen patients. Am J Hum Genet 73(6):1027-1040, 2003.

Fonseca R, Blood E, Rue M, Harrington D, Oken MM, Kyle RA, Dewald GW, Van Ness B, Van Wier SA, Henderson KJ, Bailey RJ, Greipp PR. Clinical and biologic implications of recurrent genomic aberrations in myeloma. Blood 101: 4569-4575, 2003.

Fonseca R, Debes-Marun CS, Picken EB, Dewald GW, Bryant SC, Winkler JM, Blood E, Oken MM, Santana-Davila R, Gonzalez-Paz N, Kyle RA, Gertz MA, Dispenzieri A, Lacy MQ, Greipp PR. The recurrent IgH translocations are highly associated with non-hyperdiploid variant multiple myeloma. Blood 102: 2562-2567, 2003.

Hackett C, Hodgson G, Law ME, Fridlyand J, Jain A, Jenkins R, Gray JW, Weiss WA. Genome-wide array CGH analysis of murine neuroblastoma reveals distinct patterns of chromosome gains and losses which parallel those in human tumors. Cancer Res 63:5266-5273, 2003.

Howe R, Micallef IN, Inwards DJ, Ansell SM, Dewald GW, Dispenzieri A, Gastineau DA, Gertz MA, Geyer SM, Hanson CA, Lacy MQ, Tefferi A, Litzow MR. Secondary myelodysplastic syndrome and acute myelogenous leukemia are significant complications following autologous stem cell transplantation for lymphoma. Bone Marrow Transplant 32: 317-24, 2003.

Jalal SM, Harwood AR, Sekhon GS, Pham Lorentz C, Ketterling RP, Babovic-Vuksanovic D, Meyer RG, Ensenauer R, Anderson MH, Michels VV. Utility of subtelomeric fluorescent DNA probes for detection of chromosome anomalies in 425 patients. Genet Med 5(1):28-34, 2003.

Kay NE, Jelinek DF, Dewald GW. Advances in prognosis and biologic understanding of B-cell chronic lymphocytic leukemia by fluorescence in situ hybridization and gene profile testing. The cutting edge 8: 5-7, 2003.

Kitange GJ, Templeton KL, Jenkins RB. Recent advances in molecular genetics of primary gliomas. (Review) Opin Oncol 15:197-203, 2003.

Mascarello JT, Cooley LD, Davison K, Dewald GW, Brothman AR, Herrman M, Park JP, Persons DL, Rao KW, Schneider NR, Vance GH. As currently formulated, ISCN FISH nomenclature is not practical for use in clinical test reports or cytogenetic databases. Genetics in Medicine 5: 370-377, 2003.

Mesa RA, Steensma DP, Houer J, Ketterling RP. Concomitant myelodysplastic syndrome and chronic myeloid leukaemia: treatment outcomes with imatnib mesylate. Br J Haematol 123(2):366-367, 2003.

Paietta E, Neuberg D, Bennett JM, Dewald G, Rowe JM, Cassileth PA, Cripe L, Tallman MS, Wiernik PH. Low expression of the myeloid differentiation antigen CD65s, a feature of poorly differentiated AML in older adults: study of 711 patients enrolled in ECOG trials. Leukemia 17: 1544-1550, 2003.

Pardanani A, Ketterling RP, Brockman SR, Flynn HC, Paternoster SF, Shearer BR, Reeder TL, Li CY, Cross NC, Cools J, D. Gilliland DG, Dewald GW, Tefferi A. CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy. Blood 102: 3093-3096, 2003.

Reeder TL, Bailey RJ, Dewald GW, Tefferi A. Both B and T lymphocytes may be clonally involved in myelofibrosis with myeloid metaplasia. Blood 101: 1981-1983, 2003.

Rowe JM, Neuberg D, Friedenberg W, Bennett JM, Paietta E, Makary AZ, Liesveld JL, Abboud CN, Dewald GW, Hayes FA, Tallman MS, Wiernik PH. A phase III study of three induction regimens and of priming with GM-CSF in older adults with acute myeloid leukemia: a trial by the Eastern Cooperative Oncology Group. Blood First Edition Paper, prepublished online September 25, 2003; DOI 10.1182/blood-2003-05-1686, 2003.

Steensma DP, Dewald GW, Hodnefield JM, Tefferi A, Hanson CA. Clonal cytogenetic abnormalities in bone marrow specimens without clear morphologic evidence of dysplasia: a form fruste of myelodysplasia. Leukemia Research 27: 235-242, 2003.

Tonk VS, Jalal SM, Gonzalez J, Kennedy A, Velagaleti GVN. Familial interstitial deletion of chromosome 4 (p15.2p16.1). Ann Genet 46:453-458, 2003.

van den Bent MJ, Looijenga LHJ, Langenberg K, Dinjens WNM, Graveland W, Uytdewilligen L, Sillevis Smitt PAE, Jenkins RB, Kros JM. Chromosomal anomalies in oligodendroglial tumors are correlated with clinical features. Cancer 97:1276-1284, 2003.

Velagaleti GVN, Jalal SM, Michaelis RC, Rowe TF, Nichols JR, Lockhart LH. Molecular cytogenetic characterization of a de novo unbalanced translocation leading to trisomy 17q25→qter and monosomy 18p11.3→pter in a girl with dysmorphic features. Clin Dysmorphol 12:29-33, 2003.

Book Chapters

Adeyinka, A, Dewald, GW: Cytogenetics of chronic myeloproliferative disorders and related myelodysplastic syndromes. In, Hematology/Oncology Clinics of North America (Nathaniel I. Berlin, ed.) Elsevier Press, Philadelphia, pp 1129-1149, 2003.

Dewald GW, Litzow M: Cytogenetics of Acute Leukemia. In, Neoplastic Diseases of the Blood. (Wiernik PH. Canellos GP, Kyle RA, Schiffer CA, eds.) 4th edition Cambridge University Press, pp 232-248, 2003.

Jalal SM, Ketterling RP. Euchromatic Variants 75-86. In Atlas of Human Chromosomes:Heteromorphisms edited by H. E. Herman and V. S. Tonk. Kluwer Academic Press, page 273, 2003.