Laboratory Genetics in Minnesota

2002 Publications from the Cytogenetics Laboratory

Original Articles
Reviews and Chapters

The following 2002 peer reviewed publications were produced by the Cytogenetics Laboratory and illustrate most of the areas we have been investigating. As a laboratory, we published 42 papers and 6 book chapters during 2002. The total career bibliography of the four laboratory directors combined totals 496 peer reviewed publications, 493 abstracts, 36 book chapters and 2 books that involve a wide variety of cytogenetic investigations.

Original Articles

Burton EC, Lamborn KR, Forsyth P, Scott J, O'Campo J, Uyehara-Lock J, Prados M, Berger M, Passe S, Uhm J, O'Neill BP, Jenkins RB, Aldape KD: Aberrant p53, mdm2, and proliferation differ in glioblastomas from long-term compared with typical survivors. Clin Cancer Res 8:180-187, 2002.

Carpten J, Nupponen N, Isaacs S, Sood R, Robbins C, Xu J, Farugue M, Moses T, Ewing C, Gillanders E, Hu P, Bujnovszky P, Makalowska I, Baffoe-Bonnie A, Faith D, Smith J, Stephan D, Wiley K, Brownstein M, Gildea D, Kelly B, Jenkins R, Hostetter G, Matikainen M, Schleutker J, Klinger K, Connors T, Xiang Y, Wang Z, De Marzo A, Papadopoulos N, Kallioniemi OP, Burk R, Meyers D, Grönberg H, Meltzer P, Silverman R, Bailey-Wilson J, Walsh P, Isaacs W, Trent J: Germline mutations in the ribonuclease L gene in families showing linkage with HPC1. Nat Genet 30:181-184, 2002.

Cheville JC, Tindall D, Boelter C, Jenkins R, Lohse CM, Pankratz VS, Sebo TJ, Davis B, Blute ML. Metastatic prostate carcinoma to bone: clinical and pathologic features associated with cancer-specific survival. Cancer 95:1028-1036, 2002.

Dewald GW: Cytogenetic and FISH studies in myelodysplasia, acute myeloid leukemia, chronic lymphocytic leukemia and lymphoma. International Journal of Hematology 76:65-74, 2002.

Eley GD, Reiter JL, Pandita A, Park S, Jenkins RB, Maihle NJ, James CD: A chromosomal region 7p11.2 transcript map: Its development and application to the study of EGFR amplicons in glioblastoma. Neuro-oncol 4:86-94, 2002.

Elliott MA, Letendre L, Hanson CA, Tefferi A, Dewald GW: The prognostic significance of trisomy 8 in acute myeloid leukemia (AML). Leukemia and Lymphoma 43(3):583-586, 2002.

Faruqi SA, Noumoff MJ, Dyer RB, Jalal SM, Pontoniades K. Trisomy 21 as the only chromosomal anomaly in a clinically aggressive ovarian carcinoma. Cancer Genet Cytogenet 138:165-168, 2002.

Fonseca R, Bailey RJ, Ahmann GJ, Fajkumar SV, Hoyer JD, Lust JA, Kyle RA, Gertz MA, Greipp PR, Dewald GW: Genomic abnormalities in monoclonal gammopathy of undetermined significance. Blood 100:1417-24, 2002.

Fonseca R, Blood EA, Oken MM, Kyle RA, Dewald GW, Bailey RJ, Van Wier SA, Henderson KH, Hoyer JD, Harrington D, Kay NE, Van Ness B, Greipp PR: Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients. Blood 99: 3735-3741, 2002.

Fonseca R, Harrington D, Oken MM, Dewald GW, Bailey RJ, Van Wier SA, Henderson KJ, Blood EA, Rajkumar SV, Kay NE, Van Ness B, Greipp P. Biological and prognostic significance of interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities (D13) in multiple myeloma: an Eastern Cooperative Oncology Group Study. Cancer Research 62: 715-720, 2002.

Halling KC, King W, Sokolova IA, Karnes RJ, Meyer RG, Powell EL, Sebo TJ, Cheville JC, Clayton AC, Krajnik KL, Ebert TA, Nelson RE, Burkhardt HM, Ramakumar S, Stewart CS, Pankratz VS, Lieber MM, Blute ML, Zincke H, Seelig SA, Jenkins RB, and O'Kane DJ. A Comparison of BTA-Stat, Hemoglobin Dipstick, Telomerase, and UroVysionTM Assays for the Detection of Urothelial Carcinoma in Urine. J Urol, 2002;167(5):2001-2006.

Hartmann C, Johnk L, Kitange G, Wu Y, Ashworth LK, Jenkins RB, Louis DN: Transcript map of the 3.7-Mb D19S112-D19S246 candidate tumor suppressor region on the long arm of chromosome 19. Cancer Res 62:4100-4108, 2002.

Hartmann C, Johnk L, Sasaki H, Jenkins RB, Louis DN: Novel PLA2G4C polymorphism as a molecular diagnostic assay for 19q loss in human gliomas. Brain Pathol 12:178-182, 2002.

Kay NE, Bone ND, Tschumper RC, Howell KH, Geyer SM, Dewald GW, Hanson CA, Jelinek DF: B-CLL cells are capable of synthesis and secretion of both pro- and anti-angiogenic molecules. Leukemia 16: 911-919, 2002.

Kay NE, Hamblin TJ, Jelinek DF, Dewald GW, Byrd JC, Farag S, Lucas M, Lin T: Chronic lymphocytic leukemia. Hematology (American Society of Hematology Education Program) 2002:193-213, 2002.

Ketterling RP, Wyatt WA, Van Wier SA, Law M, Hodenfeld J, Hanson CA, Dewald GW: Primary myelodysplastic syndrome with normal cytogenetics: utility of "FISH panel testing" and M-FISH. Leukemia Research 26: 235-240, 2002.

Kumar S, Menke DM, Dewald GW, Colon-Otero G: Agnogenic myeloid metaplasia associated with Klinefelter syndrome: a case report. Annals of Hematology 81(4):215-218, 2002.

Kuriyama H, Lamborn KR, O'Fallon JR, Iturria N, Sebo T, Schaefer PL, Scheithauer BW, Buckner JC, Kuriyama N, Jenkins RB, Israel MA: Prognostic significance of an apoptotic index and apoptosis/proliferation ratio for patients with high-grade astrocytomas. Neuro-Oncol 4:179-186, 2002.

Lesser ML, Dewald GW, Sison CP, Silver RT: Correlation of three methods of measuring cytogenetic response in chronic myeloid leukemia (CML). Cancer Genetics and Cytogenetics 137:79-84, 2002.

Levy B, Jalal SM, Sunn TM, Warburton PE, Tonk VX, Hirschhorn K, Lockhart LH, Hughes T, Velagaleti GVN. A unique case of mosaicism involving two morphologically similar marker chromosomes of different centric origin in a patient with developmental delay. Am J Med Genet 108:198-204, 2002.

Lorentz CP, Jalal SM, Link DT, Babovic-Vuksanovic D. Mosaic r(13) resulting in large deletion of chromosome 13q in a newborn female with multiple congenital anomalies. Am J Med Genet 111:61-67, 2002.

Lorentz CP, Wieben ED, Tefferi A, Whiteman DAH, Dewald, GW. A primer on medical genomics – Part I: History of genetics and sequencing of the human genome. Mayo Clinic Proceedings 77:773-782, 2002.

Mascarello JT, Brothman AR, Davison K, Dewald GW, Herrman M, McCandless D, Park JP, Persons DL, Rao KW, Schneider NR, Vance GH, Cooley LD for the Cytogenetics Resource Committee of the College of American Pathologists and American College of Medical Genetics: Proficiency Testing for Laboratories Performing Fluorescence In Situ Hybridization With Chromosome-Specific DNA Probes. Archives of Pathology and Laboratory Medicine. 126:1458-1462, 2002.

O'Neill BP, Blondal H, Yang P, Olafsdottir GH, Sigvaldason H, Jenkins RB, Kimmel DW, Scheithauer BW, Rocca WA, Bjornsson J, Tulinius H: Risk of cancer among relatives of patients with glioma. Cancer Epidemiol Biomarkers Prev 11:921-924, 2002.

Paternoster SF, Brockman SR, McClure RF, Remstein ED, Kurtin PJ, Dewald GW: A new method to extract nuclei from paraffin-embedded tissue to study lymphomas using interphase FISH. American Journal of Pathology 160(6):1967-1972, 2002.

Perez EA, Roche PC, Jenkins RB, Reynolds CA, Halling KC, Ingle JN, Wold LE: HER2 testing in patients with breast cancer: Poor correlation between weak positivity by immunohistochemistry and gene amplification by fluorescence in situ hybridization. Mayo Clin Proc 77:148-154, 2002.

Qian J, Hirasawa K, Bostwick DG, Bergstralh EJ, Slezak JM, Anderl KL, Borell TJ, Lieber MM, Jenkins RB: Loss of p53 and c-myc overrepresentation in stage T2-3N1-3M0 prostate cancer are potential markers for cancer progression. Mod Pathol 15:35-44, 2002.

Reeder TL, Bailey RJ, Dewald GW, Tefferi A: Both B and T lymphocytes may be clonally involved in myelofibrosis with myeloid metaplasia. Blood Oct 24, 2002. Blood First Edition Paper, prepublished online October 24, 2002; DOI 10.1182/blood-2002-07-2341.

Remstein E, Kurtin P, James C, Wang X, Meyer R, Dewald G: Mucosa-associated lymphoid tissue lymphomas with t(11;18)(q21;q21) and MALT lymphomas with aneuploidy develop along different pathogenetic pathways. American Journal of Pathology 161(1): 63-71, 2002.

Roche PC, Suman VJ, Jenkins RB, Davidson NE, Martino S, Kaufman PA, Addo FK, Murphy B, Ingle JN, Perez EA: Concordance between local and central laboratory HER2 testing in the breast intergroup trial N9831. J Natl Cancer Inst 94:855-857, 2002.

Schop RFJ, Jalal SM, VanWier SA, Ahmann GJ, Bailey RJ, Kyle RA, Greipp PR, Rajkumar SV, Gertz MA, Lust JA, Lacy MQ, Dispenzieri A, Witzig TE, Fonseca R. Deletions of 17p13.1 and 13q14 are uncommon in Waldenstrom macroglobulinemia clonal cells and mostly seen at the time of disease progression. Cancer Genet Cytogenet 132:55-60, 2002.

Schop RFJ, Kuehl WM, VanWier SA, Ahmann GJ, Price-Troska T, Bailey RJ, Jalal SM, Qi Y, Kyle RA, Greipp PR, Fonseca R. Waldenström's macroglobulinemia neoplastic cells lack immunoglobulin heavy chain locus translocations but have frequent 6q deletions. Blood 100:2996-3001, 2002.

Sinclair CS, Adem C, Naderi A, Soderberg CL, Johnson M, Wu K, Wadum L, Couch VL, Sellers TA, Schaid D, Slezak J, Fredericksen Z, Ingle JN, Hartmann L, Jenkins RB, Couch FJ: TBX2 is preferentially amplified in BRCA1- and BRCA2-related breast tumors. Cancer Res 62:3587-3591, 2002.

Sokolova IA, Bubendorf L, O'Hare A, Legator MS, Jacobson KK, Grilli BSB, Dalquen P, Halling KC, Tamm M, Seelig SA, Morrison LE. A fluorescence in situ hybridization-based assay for improved detection of lung cancer cells in bronchial washing specimens. Cancer 2002 October 25;96(5):306-315.

Subramaniam M, Jalal SM, Rickard DJ, Harris SA, Bolander ME, Spelsberg TC. Further characterization of human fetal osteoblastic hFOB 1.19 and hFOB/ER_ cells: Bone formation in vivo and karyotype analysis using multicolor fluorescent in situ hybridization. J Cell Biochem 87:9-15, 2002. (M-FISH figure was used on the cover page of the journal.)

Tefferi A, Mesa RA, Gray LA, Steensma DP, Camoriano JK, Elliott MA, Pardanani A, Ansell SM, Call TG, Colon-Otero G, Schroeder G, Hanson CA, Dewald GW, Kaufmann SH: Phase 2 trial of imatinib mesylate in myelofibrosis with myeloid metaplasia. Blood 99:3854-3856, 2002.

Tefferi A, Wieben ED, Dewald GW, Whiteman DAH, Bernard ME, Spelsberg TC: Primer on medical genomics Part II: background principles and methods in molecular genetics. Mayo Clinic Proceedings 77:785-808, 2002.

Tsuchiya N, Kondo Y, Takahashi A, Pawar H, Qian J, Sato K, Lieber MM, Jenkins RB: Mapping and gene expression profile of the minimally overrepresented 8q24 region in prostate cancer. Am J Pathol 160:1799-1806, 2002.

Tsuchiya N, Slezak JM, Lieber MM, Bergstralh EJ, Jenkins RB: Clinical significance of alterations of chromosome 8 detected by fluorescence in situ hybridization analysis in pathologic organ-confined prostate cancer. Genes Chromosomes Cancer 34:363-371, 2002.

Tubbs RR, His ED, Linden MD, Pettigrew NM, Rickert RR, Said JW, Bayer-Garner IB, Nagle RB, Cooley LD, Brothman AR, Persons DL, Vance GH, Mascarello JT, Rao KW, Hermann M, Dewald G, Park JP: Clinical laboratory assays for Her-2/neu amplification and overexpression: quality assurance, standardization and proficiency testing. Archives of Pathology and Laboratory Medicine 126: 803-808, 2002.

Velagaleti GVN, Jalal SM, Kukolich MK, Lockhart LH, Tonk VS. De novo supernumerary ring chromosome 7: first report of a non-mosaic patient and review of literature. Clin Genet 61: 202-206, 2002.

Wei JL, Scheithauer BW, Smith JS, Jenkins RB, Passe SM, Arndt CA, Strome SE: Case Report: Primary neuroblastoma of the maxillary sinus. Intl J Ped Otorhinolaryngol 63:155-162, 2002.

Book Chapters

Dewald GW, Ketterling RP, Wyatt WA, Stupca PJ: Cytogenetic Studies in Neoplastic Hematologic Disorders. In: Clinical Laboratory Medicine, 2nd edition KD McClatchey (ed). Williams and Wilkens, Baltimore. pp658-685, 2002.

Dewald GW: Chromosome study of autopsy tissues. In: Current Methods of Autopsy Practice, 3rd Edition, J Ludwig (ed). Humana Press, Inc., Totowa, pp107-111, 2002.

Dewald GW: Interphase FISH studies for chronic myeloid leukemia. In, Methods in Molecular Biology, Vol. 204: Molecular Cytogenetics: Protocols and Applications, Y.S. Fan (ed). Humana Press, USA., Totowa NJ, pp 311-342, 2002.

Jalal SM, Law ME. Multicolor FISH. In, Methods in Molecular Biology, Vol. 204: Molecular Cytogenetics: Protocols and Applications, pp. 105-120 (Y.S. Fan, ed). Humana Press, Totowa, New Jersey, 2002.

James CD, Smith JS, Jenkins RB: Genetic and Molecular Basis of Primary Central Nervous System Tumors. In: Cancer in the Nervous System, VA Levine (ed). Oxford University Press, New York, pp. 239-251, 2002.

Ketterling RP, and Burgart LJ. Pathology of the Pancreas. In: Essentials in Anatomic Pathology, L Cheng, D Bostwick (ed) 2002.