Mayo Clinic doctors have experience in conducting positive crossmatch kidney transplants. In a positive crossmatch kidney transplant, you're not compatible with your kidney donor because your body has developed antibodies that react against your living-donor's organs and their cells.
Your transplant team provides you with medical treatment before and after your transplant to reduce your risk of antibodies rejecting the kidney transplant. Your treatment to reduce your risk of rejection may include a process of removing antibodies from your blood (plasmapheresis), injecting antibodies into your body that protect you from infections (intravenous immunoglobin) and other medications that protect your new kidney from antibodies.
Mayo Clinic researchers were among the first to develop treatments to remove antibodies and block their effects, which reduced the risk of rejection of a donor kidney. Researchers continue to study the effects of antibodies after a kidney transplant and potential treatments to lower antibody levels. The goal of research is to prevent rejection of a donor kidney.