Mayo Clinic in Florida was established in 1986 as a comprehensive medical facility in the southeastern United States, where quality patient care is supported by advanced programs in education and research. Today, medical, surgical and research staff on the Jacksonville campus represent more than 40 medical and surgical specialties.

Mayo Clinic integrated its inpatient and outpatient services in northeast Florida with the opening of Mayo Clinic Hospital in 2008. The hospital's liver transplant program is the largest in the country, and other transplant programs include bone marrow, pancreas, kidney, heart and lung. The hospital also has epilepsy units, advanced cardiac and neurosurgery facilities, and a full-service emergency room.

Two research facilities on campus focus primarily on neurological diseases such as Alzheimer's and Parkinson's and cancer research.