Irritable Bowel Syndrome

Clinical Trials

Below is a list of Irritable Bowel Syndrome clinical trials from the clinical trials database at Mayo Clinic.

Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

A Placebo-Controlled Trial of Pregabalin (Lyrica) for Irritable Bowel Syndrome
This study is being done to see if Lyrica helps people with irritable bowel syndrome, otherwise known as "IBS". Lyrica is the trade name for pregabalin, which was first approved by the FDA in June 2005 and has been available through prescription since fall 2005, and is marketed by Pfizer.
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Effect of TU-100 on Rectal Compliance, Rectal Sensation and Small Bowel and Colonic Transit in Females With Constipation
The purpose of this study is to assess the dose-related effects of TU-100, a botanical agent that modulates gastrointestinal nerves, on rectal compliance, rectal sensation thresholds and small bowel and colonic transit in female patients with functional constipation as compared to placebo.
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Gluten Intolerance in Patients With Diarrhea Predominant Irritable Bowel Syndrome
The study design is a double-blind, randomized, controlled, parallel-group, 6-week study comparing the effects of gluten rich versus gluten free diets in diarrhea or diarrhea predominant IBS patients. All participants will keep a daily bowel pattern diary throughout the study.
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Neomycin vs. Rifaximin Plus Neomycin in the Treatment of Methane Positive Subjects with Constipation-Predominant Irritable Bowel Syndrome (C-IBS)
The purpose of this study is to compare the antibiotic, neomycin, to a combination of antibiotics, rifaximin and neomycin, in individuals with C-IBS in order to evaluate the safety and effectiveness of the these medications.
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Pediatric Inflammatory Bowel Disease Collaborative Research Group Registry
Observations of children with IBD often suggest a more severe course than that found in adults. Explanations for this are unclear, especially since children are less likely to engage in some behaviors (e.g.,
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Pregabalin on Colonic Motor and Sensory Function in Constipation Predominant Irritable Bowel Syndrome
Specific aims of the protocol: 1. To quantify the effect of a single administration of 200mg pregabalin on colonic sensory and motor functions in constipation predominant IBS adults. 2. To assess the potential relationship between any analgesic properties of pregabalin and its effect on compliance in constipation predominant IBS adults.
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Study of Asimadoline to Treat Diarrhea-Predominant Irritable Bowel Syndrome (D-IBS)
The primary objective of the study is to compare the efficacy of the two treatments with respect to improvement in IBS-related abdominal pain severity and reduction in stool frequency. During the 12-week treatment period, daily IBS-related abdominal pain severity score and daily frequency of bowel movements will be averaged over each week to determine average values for each endpoint.
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Study of Asimadoline to Treat Diarrhea-Predominant Irritable Bowel Syndrome (D-IBS)
The purpose of this study is to determine whether asimadoline is safe and effective at treating D-IBS.
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