The initial goal in diagnosing hypereosinophilic syndrome is
to rule out other disorders that can elevate your eosinophil
count — such as a parasitic infection, allergic disease or
drug reaction. Provide your travel history and a list of any
medications you're taking to your doctor.
Ruling out other conditions
Your symptoms determine what types of tests will be
recommended for a diagnosis. Some tests to rule out other
- Blood tests. Blood tests may reveal
autoimmunities, parasitic infections, or impaired liver or kidney
- Allergy tests. Environmental or food
allergies can elevate your eosinophil count.
- Stool tests. Stool evaluations can detect
parasitic infections that affect your eosinophil count, such as
- Imaging tests. Chest X-rays, computerized
tomography (CT) scans and echocardiograms help evaluate the
condition of your heart, abdomen and lungs.
Determining the cause of your HES
If you've been diagnosed with HES, these tests may help
determine the cause:
- Blood screening. This test can reveal a
genetic mutation known as FIP1L1-PDGFRA, which can cause
- Bone marrow biopsy. If your blood screen is
negative for a genetic mutation, this test may be considered.
Biopsies are also useful because they help exclude the
possibility of other conditions.