Chronic kidney disease, also called chronic kidney failure, describes the gradual loss of kidney function. Your kidneys filter wastes and excess fluids from your blood, which are then excreted in your urine. When chronic kidney disease reaches an advanced stage, dangerous levels of fluid, electrolytes and wastes can build up in your body.
In the early stages of chronic kidney disease, you may have few signs or symptoms. Chronic kidney disease may not become apparent until your kidney function is significantly impaired.
Treatment for chronic kidney disease focuses on slowing the progression of the kidney damage, usually by controlling the underlying cause. Chronic kidney disease can progress to end-stage kidney failure, which is fatal without artificial filtering (dialysis) or a kidney transplant.
Chronic kidney disease care at Mayo Clinic
July 26, 2016
- Goldman L, et al., eds. Chronic kidney disease. In: Goldman-Cecil Medicine. 25th ed. Philadelphia, Pa.: Saunders Elsevier; 2016. http://www.clinicalkey.com. Accessed April 21, 2016.
- Ferri FF. Chronic kidney disease. In: Ferri's Clinical Advisor 2016. Philadelphia, Pa.: Mosby Elsevier; 2016. https://www.clinicalkey.com. Accessed April 21, 2016.
- AskMayoExpert. Chronic kidney disease (adult). Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2015.
- Bope ET, et al. The urogenital tract. In: Conn's Current Therapy 2016. Philadelphia, Pa.: Elsevier; 2016. http://www.clinicalkey.com. Accessed May 3, 2016.
- About chronic kidney disease: A guide for patients and their families. National Kidney Foundation. http://www.kidney.org/atoz/content/aboutckd.cfm. Accessed May 3, 2016.
- Rosenberg M. Overview of the management of chronic kidney disease in adults. http://www.uptodate.com/home. Accessed April 21, 2016.
- Coping effectively: A guide for patients and their families. The National Kidney Foundation. https://www.kidney.org/atoz/content/coping_effectively_guide. Accessed May 3, 2016.
- Chronic kidney disease: What does it mean for me? National Institute of Diabetes and Digestive and Kidney Diseases. http://www.niddk.nih.gov/health-information/health-communication-programs/nkdep/a-z/kidney-disease-mean-for-me/Pages/default.aspx. Accessed April 28, 2016.
- Chronic kidney disease (CKD) and diet: Assessment, management and treatment. National Kidney Disease Education Program. http://www.niddk.nih.gov/health-information/health-communication-programs/nkdep/a-z/Documents/ckd-diet-assess-manage-treat-508.pdf. Accessed April 28, 2016.
- Kidney failure: Choosing a treatment that's right for you. National Institute of Diabetes and Digestive and Kidney Diseases. http://www.niddk.nih.gov/health-information/health-topics/kidney-disease/kidney-failure-choosing-a-treatment-thats-right-for-you/Pages/facts.aspx. Accessed May 3, 2016.
- Cook AJ. Allscripts EPSi. Mayo Clinic, Rochester, Minn. Feb. 23, 2016.
- Heilman RL (expert opinion). Mayo Clinic, Phoenix, Ariz. May 12, 2016.