What are the side effects of DHEA?
DHEA is a hormone and part of a steroid pathway. There are concerns that using it as a supplement may increase the risk of hormone-sensitive cancers, including prostate, breast and ovarian cancers. The National Collegiate Athletic Association has banned DHEA use among athletes.
DHEA has been linked to:
- Reduced high-density lipoprotein (HDL), or "good," cholesterol levels
- Increased facial hair in women or hair loss
- Mania and heart palpitations
- Liver problems
- High blood pressure
- Insulin resistance
Supplements such as DHEA can also cause serious adverse effects when mixed with prescription or nonprescription drugs.
What do you tell people who want to try DHEA?
DHEA supplementation doesn't have proven benefits in older adults and might cause adverse side effects. Don't take DHEA to prevent, delay or reverse age-related changes in your body or to boost athletic performance.
Instead, remember that there's no substitute for a healthy lifestyle. Maintain a healthy weight, eat a balanced diet, include physical activity in your daily routine, and seek regular health screenings.
Sept. 09, 2014
See more In-depth
- AskMayoExpert. What is dehydroepiandrosterone (DHEA)? Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014.
- Chrousos GP. Dehyrdoepiandrosterone and its sulfate. http://www.uptodate.com/home. Accessed July 23, 2014.
- Pizzorno JE, et al. Textbook of Natural Medicine. 4th ed. Philadelphia, Pa.: Churchill Livingstone Elsevier; 2013. https://www.clinicalkey.com. Accessed July 23, 2014.
- Merritt P, et al. Administration of dehydroepiandrosterone (DHEA) increases serum levels of androgens and estrogens but does not enhance short-term memory in post-menopausal women. Brain Research. 2012;1483:54.
- Davis SR, et al. DHEA replacement for postmenopausal women. Journal of Clinical Endocrinology & Metabolism. 2011;96:1642.
- Nair KS, et al. DHEA in elderly women and DHEA or testosterone in elderly men. New England Journal of Medicine. 2006;355:1647.
- Igwebuike A, et al. Lack of dehydroepiandrosterone effect on a combined endurance and exercise resistance program in postmenopausal women. Journal of Clinical Endocrinology & Metabolism. 2008;93:534.
- Rutkowski K, et al. Dehydroepiandrosterone (DHEA): Hypes and hopes. Drugs. 2014;74:1195.
- Ferri FF. Ferri's Clinical Advisor 2015: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2015. https://www.clinicalkey.com. Accessed July 23, 2014.