Sleep aids: Understand over-the-counter options
Trouble sleeping? Over-the-counter sleep aids might help temporarily — but lifestyle changes are usually the best approach for chronic insomnia.By Mayo Clinic Staff
You've followed the usual tips for getting enough sleep — sleeping on a regular schedule, avoiding caffeine and daytime naps, exercising regularly, and managing stress. Still, it's been weeks and a good night's sleep remains elusive. Is it time for an over-the-counter sleep aid? Here's what you need to know if you're considering medication to help you sleep.
Sleep aids: Not a magic cure
Over-the-counter sleep aids can be effective for an occasional sleepless night. There are a few caveats, however.
Most over-the-counter sleep aids contain antihistamines. Tolerance to the sedative effects of antihistamines can develop quickly — so the longer you take them, the less likely they are to make you sleepy.
In addition, some over-the-counter sleep aids can leave you feeling groggy and unwell the next day. This is the so-called hangover effect.
Medication interactions are possible as well, and much remains unknown about the safety and effectiveness of over-the-counter sleep aids.
July 13, 2016
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- Bonnet MH, et al. Treatment of insomnia. http://www.uptodate.com/home. Accessed Sept. 5, 2014.
- Neubauer DN. Chronic insomnia. Continuum. 2013;19:50.
- Katayose Y, et al. Carryover effect on next-day sleepiness and psychomotor performance of nighttime administered antihistaminic drugs: A randomized controlled trial. Human Psychopharmacology Clinical and Experimental. 2012;27:428.
- Kryger MH, et al. Principles and Practice of Sleep Medicine. 5th ed. St. Louis, Mo.: Elsevier Saunders; 2011.
- Petrov ME, et al. Over-the-counter and prescription sleep medication and incident stroke: The REasons for Geographic and Racial Differences in Stroke study. Journal of Stroke and Cardiovascular Disease. 2014;23:2110.
- Taavoni S, et al. Effect of valerian on sleep quality in postmenopausal women: A randomized placebo-controlled clinical trial. Menopause: The Journal of the North American Menopause Society. 2011;18:951.
- Ferri FF. Ferri's Clinical Advisor 2015: 5 Books in 1. Philadelphia, Pa.: Mosby Elsevier; 2015. https://www.clinicalkey.com. Accessed Sept. 5, 2014.
- Side effects of sleep drugs. U.S. Food and Drug Administration. http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm107757.htm#otc Accessed Sept. 9, 2014.
- Ferracioli-Oda E, et al. Meta-analysis: Melatonin for the treatment of primary sleep disorders. PLOS One. 2013;8:E63773.
- Gray SL, et al. Cumulative use of strong anticholinergics and incident dementia: A prospective cohort study JAMA Internal Medicine. 2015;175:401.
- Fox C, et al. Anticholinergic medication use and cognitive impairment in the older population: The medical research council cognitive function and ageing study. Journal of the American Geriatric Society. 2011;59:1477.
- Carriere I, et al. Drugs with anticholinergic properties, cognitive decline, and dementia in an elderly general population: The 3-city study. Archives of Internal Medicine. 2009;169:1317.
- Rochon PA. Drug prescribing for older adults. http://www.uptodate.com/home. Accessed July 8, 2016.
- American Geriatrics Society 2015 Updated Beers Criteria for potentially inappropriate medication use in older adults. Journal of the American Geriatric Society. 2015;63:2227.