Ewing Sarcoma

Clinical Trials

Mayo Clinic participates in the national North Central Cancer Treatment Group, which develops chemotherapy treatment methods (protocols). This cooperative network has helped to develop the current standard treatment using a combination of five drugs, an approach that provides excellent survival rates.

Below is a list of Ewing Sarcoma clinical trials from the clinical trials database at Mayo Clinic.

Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

Collecting and Storing Biological Samples From Patients With Ewing Sarcoma
OBJECTIVES: - Collect biological specimens, including associated demographic and clinical data, from patients with Ewing sarcoma. - Provide a repository for long-term storage of Ewing sarcoma-related biological materials. - Make collected specimens available to qualified researchers to understand the biology of Ewing sarcoma and correlate these results with demographic and clinical data.
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Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma
OBJECTIVES: Primary - Test the effect of the combination of vincristine, cyclophosphamide, and topotecan (VTC) added to the standard 5-drug chemotherapy interval-compressed backbone on event-free survival (EFS) and overall survival of children and young adults with Ewing sarcoma.
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Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma
OBJECTIVES: Primary - Compare the event-free and overall survival of patients with tumor of the Ewing's family treated with standard induction chemotherapy comprising vincristine, dactinomycin, ifosfamide and etoposide (VIDE) followed by consolidation chemotherapy comprising vincristine, dactinomycin, and ifosfamide versus high-dose busulfan and melphalan (Bu-Mel) followed by autologous peripheral blood stem cell (PBSC) transplantation with or without radiotherapy and/or surgery.
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