Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Topiramate may be taken with or without food.

Swallow the Trokendi XR® extended-release capsule whole. Do not open, crush, chew, or sprinkle on food.

Measure the Eprontia™ oral solution with a marked measuring spoon, oral syringe, or medicine cup.

Avoid drinking alcohol with Eprontia™, Qudexy® XR, or Topamax®, or avoid for 6 hours before and 6 hours after taking the Trokendi XR® capsule.

Swallow the tablet whole. Do not break, crush, or chew it. The tablet may taste bitter if it is held in the mouth or chewed.

The Topamax® sprinkle capsule or Qudexy® XR extended-release capsule may be swallowed whole or opened and sprinkled on a small amount (1 teaspoon) of soft food (eg, applesauce). Swallow the food mixture right away without chewing. Do not save for later use.

Drink extra water with this medicine to help prevent kidney stones.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (extended-release capsules):
    • For seizures (taken with other medicines):
      • Adults—At first, 25 to 50 milligrams (mg) once a day. Your doctor may adjust the dose as needed. However, the dose is usually not more than 400 mg per day.
      • Children—
        • Qudexy®:
          • Children 2 years of age and older—Dose is based on body weight and must be determined by your doctor. The usual starting dose is 25 milligrams (mg) once a day in the evening. Your doctor may adjust the dose as needed. However, the dose is usually not more than 5 to 9 mg per kilogram (kg) of body weight per day.
          • Children younger than 2 years of age—Use is not recommended.
        • Trokendi XR®:
          • Children 6 to 16 years of age and older—At first, 25 mg once a day in the evening. Your doctor may adjust the dose as needed. However, the dose is usually not more than 5 to 9 mg per kilogram (kg) of body weight per day.
          • Children younger than 6 years of age—Use is not recommended.
    • For seizures (taken alone):
      • Qudexy®:
        • Adults and children 10 years of age and older—At first, 50 milligrams (mg) once a day. Your doctor may increase the dose as needed. However, the dose is usually not more than 400 mg per day.
        • Children 2 to 10 years of age—Dose is based on body weight and must be determined by your doctor. The starting dose is usually 25 mg once a day, in the evening. Your doctor may increase the dose as needed and tolerated. However, the dose is usually not more than 400 mg per day.
        • Children younger than 2 years of age—Use and dose must be determined by your doctor.
      • Trokendi XR®:
        • Adults and children 10 years of age and older—At first, 50 milligrams (mg) once a day. Your doctor may increase the dose each week until it reaches 400 mg once a day. The dose is usually not more than 400 mg once a day.
        • Children 6 to 9 years of age—Dose is based on body weight and must be determined by your child's doctor. The starting dose is usually 25 mg once a day in the evening. The doctor may adjust the dose as needed. However, the dose is usually not more than 250 to 400 mg per day.
          • Weighing more than 38 kilograms (kg)—250 to 400 mg once a day.
          • Weighing 32 to 38 kg—250 to 350 mg once a day.
          • Weighing 23 to 31 kg—200 to 350 mg once a day.
          • Weighing 12 to 22 kg—200 to 300 mg once a day.
          • Weighing 11 kg or less—150 to 250 mg once a day.
        • Children younger than 6 years of age—Use and dose must be determined by your doctor.
    • For migraine headaches:
      • Adults and children 12 years of age and older—At first, 25 milligrams (mg) once a day. Your doctor may adjust the dose as needed. However, the dose is usually not more than 100 mg per day.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.
  • For oral dosage forms (capsules or tablets):
    • For seizures (taken with other medicines):
      • Adults and children 17 years of age and older—At first, 25 or 50 milligrams (mg) once a day. Your doctor may adjust the dose as needed. However, the dose is usually not more than 400 mg per day.
      • Children 2 to 16 years of age—Dose is based on body weight and must be determined by your child's doctor. The starting dose is usually 25 milligrams (mg) once a day in the evening. The doctor may adjust the dose as needed.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.
    • For seizures (taken alone):
      • Adults and children 10 years of age and older—At first, 50 milligrams (mg) per day, taken in 2 divided doses. Your doctor may adjust the dose as needed. However, the dose is usually not more than 400 mg per day.
      • Children 2 to 9 years of age—Dose is based on body weight and must be determined by your child's doctor. The starting dose is usually 25 mg once a day in the evening. The doctor may adjust the dose as needed. However, the dose is usually not more than 250 to 400 mg per day.
        • Weighing more than 38 kilograms (kg)—250 to 400 mg per day taken in 2 divided doses.
        • Weighing 32 to 38 kg—250 to 350 mg per day taken in 2 divided doses.
        • Weighing 23 to 31 kg—200 to 350 mg per day taken in 2 divided doses.
        • Weighing 12 to 22 kg—200 to 300 mg per day taken in 2 divided doses.
        • Weighing 11 kg or less—150 to 250 mg per day taken in 2 divided doses.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.
    • For migraine headaches:
      • Adults and children 12 years of age and older—At first, 25 milligrams (mg) once a day in the evening. Your doctor may adjust the dose as needed. However, the dose is usually not more than 100 mg per day.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.
  • For oral dosage forms (solution):
    • For seizures (taken with other medicines):
      • Adults and children 17 years of age and older—At first, 25 or 50 milligrams (mg) once a day. Your doctor may adjust the dose as needed. However, the dose is usually not more than 400 mg per day.
      • Children 2 to 16 years of age—Dose is based on body weight and must be determined by your child's doctor. The starting dose is usually 25 milligrams (mg) once a day in the evening. The doctor may adjust the dose as needed.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.
    • For seizures (taken alone):
      • Adults and children 10 years of age and older—At first, 50 milligrams (mg) per day, taken in 2 divided doses. Your doctor may adjust the dose as needed. However, the dose is usually not more than 400 mg per day.
      • Children 2 to 9 years of age—Dose is based on body weight and must be determined by your child's doctor. The starting dose is usually 25 mg once a day in the evening. The doctor may adjust the dose as needed. However, the dose is usually not more than 250 to 400 mg per day.
        • Weighing more than 38 kilograms (kg)—250 to 400 mg per day taken in 2 divided doses.
        • Weighing 32 to 38 kg—250 to 350 mg per day taken in 2 divided doses.
        • Weighing 23 to 31 kg—200 to 350 mg per day taken in 2 divided doses.
        • Weighing 12 to 22 kg—200 to 300 mg per day taken in 2 divided doses.
        • Weighing 11 kg or less—150 to 250 mg per day taken in 2 divided doses.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.
    • For migraine headaches:
      • Adults and children 12 years of age and older—At first, 25 milligrams (mg) once a day in the evening. Your doctor may adjust the dose as needed. However, the dose is usually not more than 100 mg per day.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If your next regular dose of Topamax® capsule or tablet or Eprontia™ oral solution is within 6 hours away, wait until then to use the medicine and skip the missed dose.

If you miss more than 1 dose of Topamax® capsule or tablet orEprontia™ oral solution, contact your doctor for instructions about how to restart it.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away any unused Eprontia™ oral solution 60 days after first opening.

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Portions of this document last updated: April 01, 2024

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