Before Using

Drug information provided by: Merative, Micromedex®

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Children may be especially sensitive to the effects of local anesthetics. This may increase the chance of side effects during treatment.

Geriatric

Elderly people are especially sensitive to the effects of local anesthetics. This may increase the chance of side effects during treatment.

Pregnancy

Rectal anesthetics have not been reported to cause birth defects or other problems in humans.

Breastfeeding

Rectal anesthetics have not been reported to cause problems in nursing babies.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

  • Dronedarone
  • Saquinavir
  • Vernakalant

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Alcuronium
  • Amifampridine
  • Amiodarone
  • Amprenavir
  • Arbutamine
  • Articaine
  • Atracurium
  • Benoxinate
  • Benzocaine
  • Benzyl Alcohol
  • Bretylium
  • Bupivacaine Liposome
  • Bupropion
  • Chloroprocaine
  • Cisatracurium
  • Cobicistat
  • Cocaine
  • Darunavir
  • Dasabuvir
  • Delavirdine
  • Dibucaine
  • Disopyramide
  • Dofetilide
  • Donepezil
  • Doxacurium
  • Dronedarone
  • Dyclonine
  • Encainide
  • Ethyl Chloride
  • Etidocaine
  • Etravirine
  • Fazadinium
  • Flecainide
  • Fosamprenavir
  • Fosphenytoin
  • Gallamine
  • Hexafluorenium
  • Hyaluronidase
  • Ibutilide
  • Levobupivacaine
  • Lidocaine
  • Lopinavir
  • Mepivacaine
  • Metocurine
  • Metoprolol
  • Mexiletine
  • Mivacurium
  • Moricizine
  • Nadolol
  • Opicapone
  • Pancuronium
  • Phenytoin
  • Pipecuronium
  • Pramoxine
  • Prilocaine
  • Procainamide
  • Procaine
  • Propafenone
  • Proparacaine
  • Quinidine
  • Rapacuronium
  • Rocuronium
  • Ropivacaine
  • Sotalol
  • St John's Wort
  • Succinylcholine
  • Telaprevir
  • Tetracaine
  • Tocainide
  • Tubocurarine
  • Vecuronium

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

  • Infection at or near place of treatment or
  • Large sores, broken skin, or severe injury at or near place of treatment—The chance of unwanted effects may be increased.

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Portions of this document last updated: May 01, 2024

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