Epilepsy

Clinical Trials

Below is a list of Epilepsy clinical trials from the clinical trials database at Mayo Clinic.

This list includes only trials about which Mayo researchers choose to publish information. Mayo Clinic may be conducting other trials which are not in this database. Mayo's clinical trials include experimental treatments, often unavailable elsewhere, which frequently lead to improved patient care for people worldwide. Patients should ask their doctor at Mayo about clinical trials appropriate for their situation.

A double-blind, placebo-controlled study to evaluate an investigational, oral medication for epilepsy patients with uncontrolled partial seizures.
The primary purpose of this study is to evaluate a potential new treatment for epilepsy. Researchers want to find out if the investigational drug called perampanel is safe and can help people with partial seizures who are already taking seizure medications and the current seizure medications are not enough to control those seizures. Perampanel is being tested as a possible add-on drug for people with seizures who are taking other seizure medications.
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Automated Response to Spontaneous Epileptiform Activity Using the External Responsive Neurostimulation System
This research study is being done to learn about the effects (both good and bad) of a brain stimulating device known as the External Responsive Neurostimulating System. This is an investigational device that was designed to detect seizure activity and give an electrical stimulation to the brain to try to stop it. Research has been done which suggests that electrical stimulation given at the time of an induced seizure can stop the seizure. In this study, a computer is used that will copy the function of the actual stimulator under development.
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Epilepsy Phenome/Genome Project (EPGP)
The purpose of this study is to look for genes that are the cause of epilepsy and to look for genes that have an impact on the effectiveness of over the counter and prescription medicines used to treat epilepsy.
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Prospective Seizure Frequency Clinical Investigation
The purpose of this research study is to determine if there are enough patients with hard to treat epilepsy that might qualify for a future study of a medical device that is being developed to treat epilepsy. Participants will not be testing the device during this study. The study doctor will be assessing seizure type(s) and determine how frequently they occur, and to verify if antiseizure medications can be held constant for a period of 12 weeks.
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Responsive Neurostimulator System Feasibility Clinical Investigation
Researchers at Mayo Clinic are looking at a new procedure that involves surgically placing a Responsive Neurostimulator (RNS) in the brain that may be able to suppress seizures in patients with epilepsy. This neurostimulator, thought of as a pacemaker for the brain, would be implanted in patients with epilepsy who have not responded to current treatment.
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Responsive Neurostimulator System Pivotal Clinical Investigation
Researchers at Mayo Clinic are looking at a new procedure that involves surgically placing a Responsive Neurostimulator (RNS) in the brain that may be able to suppress seizures in patients with epilepsy. This neurostimulator, thought of as a pacemaker for the brain, would be implanted in patients with epilepsy who have not responded to current treatment.
The purpose of this trial is to assess the safety and effectiveness of the RNS as an add-on therapy in reducing the frequency of seizures. Participants in the trial will continue to receive their epilepsy medications.
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