Endoscopic Ultrasound

Research

Mayo Clinic physicians have been at the forefront of endoscopic ultrasound (EUS) research in pancreatic disease, lung cancer, and esophageal cancer. EUS research activities include:

• Finding the role of EUS in lung cancer staging
• Genomic detection of micrometastases in mediastinal lymph nodes of lung cancer patients
• EUS and secretin-stimulated pancreatic juice for cytokines in the evaluation of chronic pancreatitis and pancreatic cancer
• Genomic array evaluation of esophageal cancer before and after chemo-radiotherapy
• Celiac plexus neurolysis to prevent pain in pancreatic cancer
• Genomic and proteomic evaluation of cyst fluid in pancreatic cystic neoplasms
• Ablation of pre-cancer pancreatic cysts with EUS-guided ethanol injection
• Using endoscopic ultrasound and endobronchial (within the airway) ultrasound to detect cancerous lymph nodes in the central chest (mediastinum)
• Using endoscopic ultrasound, fine-needle aspiration, and molecular diagnostic methods (real-time polymerase chain reaction) to detect microscopic cancer deposits in otherwise normal-appearing mediastinal lymph nodes
• Detecting pancreatitis and pancreatic cancer with endoscopic ultrasound and endoscopic collection of pancreatic juice after stimulation with secretin
• Detecting precancerous cystic lesions of the pancreas using EUS fine-needle aspiration and protein analysis (proteomics) of cyst fluid
• Improved control of pancreatic cancer pain with endoscopic ultrasound-guided celiac plexus neurolysis

Publications

Age-related changes in the pancreas identified by EUS: A prospective evaluation. Elizabeth Rajan, Jonathan E. Clain, Michael J. Levy, Ian D. Norton, Kenneth K. Wang, Maurits J. Wiersema, Enrique Vazquez-Sequeiros, Barbara J. Nelson, Mary L. Jondal, Rebecca K. Kendall, W. Scott Harmsen, Alan R. Zinsmeister. Gastrointestinal Endoscopy 61:401-406, 2005. [Abstract]

EUS features of recurrent transitional cell bladder cancer metastatic to the GI tract. Tony E. Yusuf, Michael J. Levy, Maurits J. Wiersema Gastrointestinal Endoscopy, 61:314-316, 2005. [Abstract]

EUS-guided trucut biopsy in establishing autoimmune pancreatitis as the cause of obstructive jaundice. Michael J. Levy, Raghuram P. Reddy, Maurits J. Wiersema, Thomas C. Smyrk, Jonathan E. Clain, Gavin C. Harewood, Randall K. Pearson, Elizabeth Rajan, Mark D. Topazian, Tony E. Yusuf, Suresh T. Chari, Bret T. Petersen. Gastrointestinal Endoscopy, 61:467-472, 2005. [Abstract]

The utility of EUS-guided FNA in the diagnosis of metastatic breast cancer to the esophagus and the mediastinum. Jason M. Sobel, Rebecca Lai, Shawn Mallery, Michael J. Levy, Maurits J. Wiersema, Bruce D. Greenwald, Naresh T. Gastrointestinal Endoscopy 61:416-420, 2005. [Abstract]