Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Reclast
  2. Zometa

Descriptions


Zoledronic acid injection is used to treat hypercalcemia (high levels of calcium in the blood) that may occur in patients with some types of cancer. It is also used to treat a cancer called multiple myeloma (tumors formed by the cells of the bone marrow) or certain types of bone metastases (the spread of cancer to the bone).

Zoledronic acid injection is used to treat Paget's disease of the bone in men and women. It is also used in men with osteoporosis and in women with osteoporosis who have gone through menopause. This medicine is used to reduce the risk of having more fractures in patients who have had a recent hip fracture.

This medicine is to be given only by or under the direct supervision of your doctor.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, zoledronic acid is used in certain patients with the following medical conditions:

  • Bone loss, in men, from taking certain medicines for prostate cancer.
  • Bone loss, in breast cancer patients, from hormone therapy (prevention).

This product is available in the following dosage forms:

  • Solution
  • Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Zoledronic acid injection is not indicated for use in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of zoledronic acid injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution in patients receiving zoledronic acid injection.

Pregnancy

Information about this zoledronic-acid-intravenous-route
Pregnancy Category Explanation
All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Anemia or
  • Bleeding problems or
  • Cancer, history of or
  • Dental or tooth problems or
  • Dental procedures or
  • Poor oral hygiene, or
  • Surgery (eg, dental surgery)—May increase risk for severe jaw problems.
  • Asthma, aspirin-sensitive or
  • Heart disease or
  • Kidney disease or
  • Mineral imbalance (eg, high or low calcium, magnesium, phosphorus, or potassium in the blood)—Use with caution. May make these conditions worse.
  • Bowel resection or
  • Parathyroid disease (eg, hypoparathyroidism) or
  • Parathyroid surgery or
  • Stomach absorption problems or
  • Thyroid surgery—These conditions may increase your risk of having hypocalcemia (low levels of calcium in the blood).
  • Dehydration (not enough water or fluid in your body)—May increase risk of severe kidney problems.
  • Hypocalcemia (low calcium in the blood) or
  • Kidney disease, severe (eg, kidney failure)—Should not be used in patients with these conditions.

Proper Use

A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for at least 15 minutes.

For hypercalcemia, this medicine is usually given only once. If your doctor decides that you need additional doses, you will receive the medicine again after at least 7 days have passed. This treatment will continue until your body responds to the medicine.

For bone cancer and multiple myeloma, this medicine is usually given every 3 to 4 weeks. This treatment will continue until your body responds to the medicine.

For osteoporosis, this medicine is usually given once a year and will continue until your body responds to the medicine.

You may also receive other medicines to help keep your body from losing too much fluid.

Your doctor may also give you vitamins containing Vitamin D and calcium. Tell your doctor if you are unable to take these supplements.

Drink extra fluids so you will pass more urine while you are using this medicine. This will keep your kidneys working well and help prevent kidney problems. However, it is very important to not drink too much liquid. Talk to your doctor about the right amount of liquids for you.

This medicine comes with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Precautions

It is very important that your doctor check your progress at regular visits after you have received zoledronic acid injection. If your condition has improved, your progress must still be checked. The results of laboratory tests or the occurrence of certain symptoms will tell your doctor if your condition is coming back and if a second treatment is needed. You will need a yearly dose of this medicine if you are being treated for postmenopausal osteoporosis, so check with your doctor regularly.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

You should not use other medicines that also contain zoledronic acid, such as Reclast® or Zometa®. Using these medicines together may increase your chance for more serious side effects.

This medicine may rarely cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving the medicine.

This medicine may cause hypocalcemia (low calcium in the blood). Low blood calcium must be corrected before you receive this medicine. Check with your doctor immediately if you have muscle spasms or twitching, or numbness or tingling in your fingers, toes, or around your mouth.

Tell your doctor right away if you have agitation, blood in the urine, confusion, decreased urine output, depression, dizziness, headache, irritability, lethargy, muscle twitching, nausea, rapid weight gain, seizures, stupor, swelling of the face, ankles, or hands, or unusual tiredness or weakness. These could be symptoms of serious kidney problems.

Your doctor will need to know if you have a history of problems with your mouth or teeth (eg, gum disease). Make sure your doctor knows if you have been treated with a bisphosphonate medicine, such as alendronate (Fosamax®), etidronate (Didronel®), pamidronate (Aredia®), risedronate (Actonel®), or tiludronate (Skelid®) in the past.

It is important that you tell all of your doctors that you are receiving zoledronic acid injection, including your dentist. If you are having dental procedures while receiving this medicine, you may have an increased chance of having a severe problem with your jaw. Make sure you tell your doctor or dentist about any new problems, such as pain or swelling, with your teeth or jaw.

Make sure you tell your doctor about any new medical problems, especially with your teeth or jaws. Tell your doctor if you have severe muscle, bone, or joint pain after receiving this medicine.

This medicine may increase your risk of developing fractures of the thigh bone. This may be more common if you use it for a long time. Check with your doctor right away if you have a dull or aching pain in the thighs, groin, or hips.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription (eg, other medicines that also contain zoledronic acid) or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Agitation
  2. black, tarry stools
  3. blurred vision
  4. chest pain
  5. chills
  6. coma
  7. confusion
  8. convulsions
  9. cough
  10. depression
  11. difficult or labored breathing
  12. dizziness
  13. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  14. fever
  15. irregular heartbeat
  16. irritability
  17. lack or loss of strength
  18. lethargy
  19. lower back or side pain
  20. muscle pain or cramps
  21. muscle trembling or twitching
  22. nausea or vomiting
  23. numbness and tingling around the mouth, fingertips, or feet
  24. painful or difficult urination
  25. pale skin
  26. rapid weight gain
  27. seizures
  28. shaking of the hands, arms, feet, legs, or face
  29. skin rash, cracks in the skin at the corners of the mouth, or soreness or redness around the fingernails and toenails
  30. sore throat
  31. sores, ulcers, or white spots on the lips or mouth
  32. stupor
  33. sudden sweating
  34. swollen glands
  35. tightness in the chest
  36. trouble breathing with exercise
  37. unusual bleeding or bruising
  38. unusual tiredness or weakness

Less common

  1. Feeling of constant movement of self or surroundings
  2. muscle cramps in the hands, arms, feet, legs, or face
  3. muscle spasms
  4. neck pain
  5. pounding in the ears
  6. rapid breathing
  7. sensation of spinning
  8. slow or fast heartbeat
  9. sunken eyes
  10. tingling of the hands or feet
  11. tremor

Incidence not known

  1. Blurred vision or other change in vision
  2. decreased frequency or amount of urine
  3. decreased vision
  4. eye pain
  5. eye tenderness
  6. heavy jaw feeling
  7. increased blood pressure
  8. increased tearing
  9. increased thirst
  10. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  11. loosening of a tooth
  12. pain, swelling, or numbness in the mouth or jaw
  13. redness of the eye
  14. sensitivity of the eye to light
  15. severe eye pain
  16. swelling of the face, hands, fingers, lower legs, or ankles
  17. weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Abdominal or stomach pain
  2. back pain
  3. bad, unusual, or unpleasant (after) taste
  4. bladder pain
  5. blistering, crusting, irritation, itching, or reddening of the skin
  6. bloody or cloudy urine
  7. bone pain
  8. burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
  9. change in taste
  10. constipation
  11. cracked lips
  12. cracked, dry, or scaly skin
  13. diarrhea
  14. difficulty with swallowing
  15. discouragement
  16. dry mouth
  17. ear congestion
  18. feeling sad or empty
  19. frequent urge to urinate
  20. hair loss or thinning hair
  21. headache
  22. hyperventilation
  23. joint pain or swollen joints
  24. loss of appetite
  25. loss of interest or pleasure
  26. loss of voice
  27. muscle stiffness or difficulty with moving
  28. nasal congestion or runny nose
  29. pain, swelling, or redness in the joints
  30. partial loss of feeling
  31. seeing, hearing, or feeling things that are not there
  32. sleepiness or unusual drowsiness
  33. sleeplessness, trouble sleeping, or unable to sleep
  34. swelling or inflammation of the mouth
  35. thirst
  36. trouble with concentrating
  37. unusually cold, shivering
  38. vomiting
  39. weight loss

Less common

  1. Acid or sour stomach
  2. belching
  3. heartburn
  4. indigestion
  5. red streaks on the skin
  6. stomach discomfort or upset
  7. swelling, tenderness, or pain at the injection site
  8. unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  9. wrinkled skin

Rare

  1. Burning, dry, or itching eyes
  2. discharge or excessive tearing
  3. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  4. throbbing pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.