Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Geodon

Descriptions


Ziprasidone is used to treat symptoms of psychotic (mental) disorders, such as schizophrenia, mania, or bipolar disorder. This medicine should not be used to treat behavioral problems in elderly patients who have dementia.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Capsule

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ziprasidone in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ziprasidone in the elderly. However, this medicine should not be used for behavioral problems in older adults with dementia.

Pregnancy

Information about this ziprasidone-oral-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Acecainide
  • Ajmaline
  • Amifampridine
  • Amiodarone
  • Amisulpride
  • Aprindine
  • Arsenic Trioxide
  • Artemether
  • Astemizole
  • Azimilide
  • Bepridil
  • Bretylium
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clozapine
  • Crizotinib
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Dronedarone
  • Droperidol
  • Enflurane
  • Erythromycin
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Foscarnet
  • Gatifloxacin
  • Gemifloxacin
  • Halofantrine
  • Halothane
  • Hydroquinidine
  • Ibutilide
  • Isoflurane
  • Isradipine
  • Ivabradine
  • Ketoconazole
  • Levomethadyl
  • Lidoflazine
  • Lorcainide
  • Lumefantrine
  • Mefloquine
  • Mesoridazine
  • Methadone
  • Metoclopramide
  • Moxifloxacin
  • Nilotinib
  • Octreotide
  • Ondansetron
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Pimozide
  • Piperaquine
  • Pirmenol
  • Posaconazole
  • Prajmaline
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Propafenone
  • Quetiapine
  • Quinidine
  • Saquinavir
  • Sematilide
  • Sertindole
  • Sorafenib
  • Sotalol
  • Sparfloxacin
  • Spiramycin
  • Sultopride
  • Tacrolimus
  • Tedisamil
  • Telithromycin
  • Terfenadine
  • Thioridazine
  • Tizanidine
  • Toremifene
  • Trifluoperazine
  • Vandetanib
  • Vasopressin
  • Vemurafenib
  • Vilanterol
  • Vinflunine
  • Zolmitriptan
  • Zotepine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Ajmaline
  • Alfuzosin
  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Apomorphine
  • Arsenic Trioxide
  • Asenapine
  • Azithromycin
  • Chlorpromazine
  • Ciprofloxacin
  • Clomipramine
  • Cyclobenzaprine
  • Dabrafenib
  • Dasatinib
  • Desipramine
  • Disopyramide
  • Doxepin
  • Eslicarbazepine Acetate
  • Fingolimod
  • Formoterol
  • Granisetron
  • Haloperidol
  • Hydromorphone
  • Hydroquinidine
  • Iloperidone
  • Imipramine
  • Lapatinib
  • Levofloxacin
  • Lopinavir
  • Mifepristone
  • Milnacipran
  • Norfloxacin
  • Nortriptyline
  • Ofloxacin
  • Paliperidone
  • Perflutren Lipid Microsphere
  • Primidone
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Protriptyline
  • Quinine
  • Ranolazine
  • Salmeterol
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sunitinib
  • Telavancin
  • Tetrabenazine
  • Trazodone
  • Trifluoperazine
  • Trimipramine
  • Vardenafil
  • Voriconazole

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Carbamazepine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alzheimer's disease or dementia or
  • Bradycardia (slow heartbeat) or
  • Dehydration or
  • Heart attack, history of or
  • Heart failure or
  • Heart or blood vessel disease or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood) or
  • Hypotension (low blood pressure) or
  • Hypovolemia (low amount of blood) or
  • Stroke, history of or
  • Trouble with swallowing—May cause side effects to become worse.
  • Blood or bone marrow problems (e.g., agranulocytosis, leukopenia, neutropenia) or
  • Breast cancer, prolactin-dependent or
  • Diabetes mellitus or
  • Hyperglycemia (high blood sugar) or
  • Hyperprolactinemia (high prolactin in the blood) or
  • Neuroleptic malignant syndrome (NMS), history of or
  • Priapism (painful or prolonged erection of the penis) or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Heart attack, recent or
  • Heart failure, uncompensated or
  • Heart rhythm problems (e.g., arrhythmia, QT prolongation), history of—Should not be used in patients with these conditions.

Proper Use

Take this medicine only as directed by your doctor even if you feel well. Do not take more of this medicine and do not take it more often than your doctor ordered. This medicine works best if there is a constant amount in the blood. To keep blood levels constant, take this medicine at the same time each day and do not miss any doses.

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Swallow the capsule whole. Do not split, crush, or chew it.

You may take this medicine with food.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (capsules):
    • For bipolar disorder:
      • Adults—At first, 40 milligrams (mg) two times per day. Your doctor may increase your dose as needed. However, the dose is usually not more than 80 mg two times per day.
      • Children—Use and dose must be determined by your doctor.
    • For schizophrenia:
      • Adults—At first, 20 milligrams (mg) two times per day. Your doctor may increase your dose as needed. However, the dose is usually not more than 80 mg two times per day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

This medicine can cause changes in the heart rhythm, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects. Call your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or irregular heartbeats.

Stop taking this medicine and check with your doctor right away if you have any of the following symptoms while using this medicine: convulsions (seizures), difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS).

This medicine may cause tardive dyskinesia (a movement disorder). Check with your doctor right away if you have lip smacking or puckering, puffing of the cheeks, rapid or worm-like movements of the tongue, uncontrolled chewing movements, or uncontrolled movements of the arms and legs while you are using this medicine.

This medicine may increase the amount of sugar in your blood. Check with your doctor right away if you have increased thirst or increased urination. If you have diabetes, you may notice a change in the results of your urine or blood sugar tests. If you have any questions, check with your doctor.

Ziprasidone can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor right away if you think you are getting an infection, or if you have a fever or chills, a cough or hoarseness, lower back or side pain, or painful or difficult urination.

If you develop a skin rash, hives, or any allergic reaction to this medicine, stop using the medicine and check with your doctor as soon as possible.

This medicine may cause some people to become drowsy or dizzy, or to have trouble with thinking or controlling body movements. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that requires you to be alert, well-coordinated, or able to think well.

Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor.

Avoid activities involving high temperature or humidity. This medicine may reduce your body's ability to adjust to the heat.

Ziprasidone may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies. If you or your caregiver notice any of these side effects, tell your doctor right away.

Avoid drinking alcohol while you are using this medicine.

This medicine may increase your weight. Your doctor may need to check your weight on a regular basis while you are using this medicine. Talk to your doctor about ways to prevent weight gain.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Cough
  2. difficulty with speaking
  3. drooling
  4. fear or nervousness
  5. fever
  6. inability to sit still
  7. loss of balance control
  8. muscle trembling, jerking, or stiffness
  9. need to keep moving
  10. restlessness
  11. shuffling walk
  12. sneezing
  13. sore throat
  14. stiffness of the limbs
  15. twisting movements of the body
  16. uncontrolled movements, especially of the face, neck, and back

Less common

  1. Blurred vision
  2. body aches or pain
  3. chest pain
  4. congestion
  5. dizziness
  6. fast, pounding, or irregular heartbeat or pulse
  7. headache
  8. hoarseness
  9. nervousness
  10. pounding in the ears
  11. runny nose
  12. slow or fast heartbeat
  13. swelling of the tongue
  14. tender, swollen glands in the neck
  15. trouble with swallowing
  16. voice changes

Rare

  1. Fainting or feeling faint
  2. feeling faint upon standing
  3. persistent, painful erection
  4. seizures

Incidence not known

  1. Inability to move the eyes
  2. increased blinking or spasms of the eyelid
  3. sticking out of tongue
  4. trouble with breathing, speaking, or swallowing
  5. uncontrolled twisting movements of the neck, trunk, arms, or legs
  6. unusual facial expressions

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Drowsiness
  2. shakiness in the legs, arms, hands, or feet
  3. sleepiness
  4. slurred speech
  5. trembling or shaking of the hands or feet

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Acid or sour stomach
  2. belching
  3. constipation
  4. diarrhea
  5. heartburn
  6. indigestion
  7. lack or loss of strength
  8. nausea
  9. rash
  10. stomach discomfort, upset, or pain
  11. weakness
  12. weight gain

Less common

  1. Blistering, crusting, irritation, itching, or reddening of the skin
  2. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  3. change in vision
  4. cracked, dry, or scaly skin
  5. depression
  6. difficulty with moving
  7. dry mouth
  8. increase in salivation
  9. itching or reddening of the skin
  10. joint pain
  11. loss of appetite
  12. muscle ache
  13. muscle pains or stiffness
  14. muscle tightness
  15. stuffy nose
  16. swelling
  17. swollen joints
  18. vomiting
  19. weakness of the arms and legs
  20. weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.