Interactions

Interactions with Drugs

Vitamin B6 may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

Vitamin B6 may affect blood sugar levels. Caution is advised when using medications that may affect blood sugar. People taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.

Vitamin B6 may cause low blood pressure. Caution is advised in people taking drugs that lower blood pressure.

Vitamin B6 may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be altered in the blood, and may cause altered effects or potentially serious adverse reactions. People using any medications should check the package insert, and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.

Vitamin B6 may also interact with agents that affect the immune or nervous system, agents that increase sun sensitivity, agents that lower homocysteine levels, agents that prevent vomiting, agents that promote breast milk, agents that stimulate red blood cell production, Alzheimer's agents, amiodarone, anti-anxiety agents, anti-asthma agents, antibiotics, anticancer agents, antidepressants, cycloserine, furosemide, hormonal agents, hydrazines, ion exchange phosphate binding resins, kidney agents, magnesium, osteoporosis agents, Parkinson's agents, penicillamine (Cuprimine®, Depen®), phenobarbital, phenytoin, and skin agents.

Interactions with Herbs and Dietary Supplements

Vitamin B6 may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Vitamin B6 may affect blood sugar levels. Caution is advised when using herbs or supplements that may affect blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.

Vitamin B6 may cause low blood pressure. Caution is advised in people taking herbs or supplements that lower blood pressure.

Vitamin B6 may interfere with the way the body processes certain herbs or supplements using the liver's "cytochrome P450" enzyme system. As a result, the levels of other herbs or supplements may be altered in the blood. It may also alter the effects that other herbs or supplements possibly have on the P450 system.

Vitamin B6 may also interact with Alzheimer's herbs and supplements, anti-asthma herbs and supplements, antibacterials, anticancer herbs and supplements, antidepressants, herbs and supplements that affect the immune or nervous system, herbs and supplements that increase sun sensitivity, herbs and supplements that lower homocysteine levels, herbs and supplements that prevent vomiting, herbs and supplements that promote breast milk, herbs and supplements that stimulate red blood cell production, hormonal herbs and supplements, ion exchange phosphate binding resins, kidney herbs and supplements, magnesium, omega-3 fatty acids, osteoporosis herbs and supplements, Parkinson's herbs and supplements, sedatives, and skin herbs and supplements.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com