Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Trelstar
  2. Trelstar Depot
  3. Trelstar LA

Descriptions


Triptorelin is used to treat advanced prostate cancer in men. It is a hormone that is similar to the one normally released from the hypothalamus gland in the brain. When given on a regular basis to men, triptorelin decreases testosterone levels which helps treat prostate cancer.

This medicine is to be given only by or under the supervision of a doctor.

This product is available in the following dosage forms:

  • Powder for Suspension

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of triptorelin in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of triptorelin in the elderly.

Pregnancy

Information about this triptorelin-intramuscular-route
Pregnancy Category Explanation
All Trimesters X Studies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Bepridil
  • Cisapride
  • Dronedarone
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Alfuzosin
  • Amiodarone
  • Amitriptyline
  • Anagrelide
  • Apomorphine
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Atazanavir
  • Azithromycin
  • Bedaquiline
  • Chloroquine
  • Chlorpromazine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Crizotinib
  • Cyclobenzaprine
  • Dabrafenib
  • Dasatinib
  • Delamanid
  • Desipramine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Doxepin
  • Droperidol
  • Ebastine
  • Eribulin
  • Erythromycin
  • Escitalopram
  • Famotidine
  • Felbamate
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Formoterol
  • Foscarnet
  • Fosphenytoin
  • Galantamine
  • Gatifloxacin
  • Gemifloxacin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Hydroquinidine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Itraconazole
  • Ivabradine
  • Ketoconazole
  • Lapatinib
  • Levofloxacin
  • Lumefantrine
  • Mefloquine
  • Methadone
  • Metronidazole
  • Mifepristone
  • Mizolastine
  • Moxifloxacin
  • Nelfinavir
  • Nilotinib
  • Norfloxacin
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Ondansetron
  • Paliperidone
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Perflutren Lipid Microsphere
  • Perphenazine
  • Pipamperone
  • Posaconazole
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Rilpivirine
  • Risperidone
  • Ritonavir
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Tizanidine
  • Tolterodine
  • Toremifene
  • Trazodone
  • Trimipramine
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Vinflunine
  • Voriconazole
  • Vorinostat

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bladder blockage or
  • Diabetes or
  • Heart or blood vessel disease or
  • Hyperglycemia (high blood sugar) or
  • Spinal cord problems—Use with caution. May make these conditions worse.
  • Congestive heart failure or
  • Electrolyte imbalance or
  • Heart rhythm problems (eg, congenital long QT syndrome)—May cause side effects to become worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use

A nurse or other trained health professional will give you this medicine. This medicine is given as a shot into your muscle (usually in the buttocks). This medicine needs to be given on a fixed schedule. Make sure you keep all of your appointments.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you receive the medicine.

When you first start using this medicine, some of your symptoms might get worse or you might have new symptoms for a short time. Tell your doctor right away if you have bone pain, back pain, a tingling or numbness in the body, blood in the urine, or trouble urinating.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

This medicine may cause changes in your blood sugar levels. Check with your doctor if you notice a change in the results of your blood or urine sugar tests.

This medicine may increase your risk of having a heart attack or stroke. Call your doctor right away if you have chest pain or discomfort, pain or discomfort in the arms, jaw, back, or neck, shortness of breath, nausea, sweating, or vomiting.

Before you have any medical tests, tell the medical doctor in charge that you are using this medicine. The results of some tests may be affected by this medicine.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

  1. Bladder pain
  2. bloating or swelling of the face, arms, hands, lower legs, or feet
  3. bloody or cloudy urine
  4. blurred vision
  5. burning while urinating
  6. chest pain
  7. cough producing mucus
  8. decrease in urine volume or frequency of urination
  9. difficult or labored breathing
  10. difficult, burning, or painful urination
  11. difficulty in passing urine
  12. dizziness
  13. dry mouth
  14. flushed, dry skin
  15. frequent urge to urinate
  16. fruit-like breath odor
  17. headache
  18. increased hunger
  19. increased thirst
  20. increased urination
  21. loss of consciousness
  22. lower back or side pain
  23. nausea
  24. nervousness
  25. pale skin
  26. pounding in the ears
  27. rapid weight gain
  28. slow or fast heartbeat
  29. stomachache
  30. sweating
  31. tightness in the chest
  32. tingling of the hands or feet
  33. troubled breathing
  34. troubled breathing with exertion
  35. unexplained weight loss
  36. unusual bleeding or bruising
  37. unusual tiredness or weakness
  38. unusual weight gain or loss
  39. vomiting

Incidence not known

  1. Anxiety
  2. changes in skin color
  3. changes in vision
  4. chest discomfort
  5. cold, clammy, or pale skin
  6. confusion
  7. dizziness or lightheadedness
  8. fainting
  9. inability to speak
  10. irregular heartbeats
  11. numbness or tingling in the face, arms, or legs
  12. pain
  13. pain or discomfort in the arms, jaw, back, or neck
  14. pain, redness, or swelling in the arm or leg
  15. seizures
  16. severe or sudden headache
  17. slow heart rate
  18. slurred speech
  19. sudden shortness of breath or troubled breathing
  20. temporary blindness
  21. tenderness
  22. trouble speaking, thinking, or walking
  23. weakness in the arm or leg on one side of the body, sudden and severe

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Bone pain
  2. chills
  3. decrease in testicle size
  4. decreased interest in sexual intercourse
  5. diarrhea
  6. feeling of warmth or redness of the face, neck, arms, and occasionally, upper chest
  7. fever
  8. general feeling of discomfort or illness
  9. inability to have or keep an erection
  10. joint pain
  11. leg pain
  12. loss in sexual ability, desire, drive, or performance
  13. loss of appetite
  14. muscle aches and pains
  15. redness of the face, neck, arms, and occasionally, upper chest
  16. runny nose
  17. shivering
  18. sore throat
  19. sudden sweating
  20. trouble sleeping

Less common

  1. Acid or sour stomach
  2. back pain
  3. belching
  4. body aches or pain
  5. breast pain
  6. burning, dry, or itching eyes
  7. congestion
  8. crying
  9. depersonalization
  10. difficulty having a bowel movement (stool)
  11. difficulty with moving
  12. discharge or excessive tearing
  13. dysphoria
  14. euphoria
  15. eye pain
  16. heartburn
  17. hoarseness
  18. indigestion
  19. injection site pain
  20. itching or rash
  21. lack or loss of strength
  22. leg cramps
  23. loss of appetite
  24. muscle aching or cramping
  25. muscle pains or stiffness
  26. pain
  27. paranoia
  28. quick to react or overreact emotionally
  29. rapidly changing moods
  30. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  31. runny nose
  32. stomach discomfort, upset, or pain
  33. swelling of the breasts or breast soreness in both females and males
  34. swollen joints
  35. tender, swollen glands in the neck
  36. trouble swallowing
  37. voice changes
  38. weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.