Dosing

The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

Adults (over 18 years old)

For anxiety, 900 milligrams of St. John's wort has been taken by mouth twice daily for several weeks.

For cancer, 0.05-0.50 milligrams per kilogram of hypericin has been taken by mouth for up to three months.

For mild to moderate depression, 20-1,800 milligrams St. John's wort has been taken by mouth once to three times for 4-52 weeks. Extracts of St. John's wort used in studies included WS® 5570, WS 5572, WS 5573, ZE 117, STW 3-VI, STW3, PM235, LoHyp-57, LI 160, Psychotonin® forte extract,and Hyperforat® and were generally standardized to contain 0.3% hypericin and 2-5% hyperforin.

For severe depression, 900-1,800 milligrams of St. John's wort (extracts LI 160 and WS® 5570) has been taken by mouth daily for 8-12 weeks.

For HIV, 0.5 milligrams per kilogram of hypericin has been taken by mouth, without evidence of benefit.

For irritable bowel syndrome, 450 milligrams of St. John's wort has been taken twice daily for 12 weeks, without evidence benefit.

For nerve pain, three 900 microgram hypericin tablets were taken by mouth for two treatment periods of five weeks each.

For obsessive-compulsive disorder, 450-1,800 milligrams (standardized to 0.3% hypericin) were taken by mouth daily for 12 weeks.

For pain due to burning mouth syndrome, 300 milligram capsules of St. John's wort (containing hypericin 0.31% and hyperforin 3.0%) have been taken by mouth three times daily for 12 weeks.

For menopausal symptoms, 300 milligrams St. John's wort (Kira®) has been taken by mouth three times daily for 12 weeks and 0.4mg hypericin drops (Hyperforat®) has been taken by mouth daily for 12 weeks.

For premenstrual syndrome (PMS), 300-900 milligrams St. John's wort (standardized to 3.38% hyperforin and 0.18% hypericin) or 1,360 micrograms of hypericin have been taken by mouth daily for two menstrual cycles.

For seasonal affective disorder (SAD), 900 milligrams and unspecified doses of St. John's wort (LI 160 and Kira®) have been taken by mouth once to three times daily with or without light therapy for 4-8 weeks.

For smoking cessation, 300 milligrams St. John's wort (LI-160 extract) has been taken by mouth once or twice daily for up to three months and a week.

For social phobia, 600-1,800 milligrams St. John's wort has been taken by mouth daily for 12 weeks.

For somatoform disorders, 300 milligrams of St. John's wort (LI 160 extract) has been taken by mouth twice daily for six weeks.

For atopic dermatitis, 1.5% hyperforin (verum) cream has been used on the skin twice daily for four weeks.

For psoriasis, St. John's wort ointment has been used two times daily on the skin for four weeks.

For wound healing, 20% St. John's wort in petroleum jelly has been used on the affected skin three times daily for 16 days.

Children (under 18 years old)

For ADHD, 300 milligrams of St. John's wort (standardized to 0.3% hypericin) has been used in children three times daily for eight weeks, without evidence of benefit.

For depression, 150-1,800 milligrams St. John's wort was taken by mouth once to three times daily for up to eight weeks.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com