Interactions

Interactions with Drugs

Soy may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants ("blood thinners") such as warfarin (Coumadin®) or heparin, anti-platelet drugs such as clopidogrel (Plavix®), and non-steroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

Soy may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. People taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.

Soy may cause high blood pressure. Caution is advised in people taking drugs that affect blood pressure.

Soy may interfere with the way the body processes certain drugs using the liver's "cytochrome P450" enzyme system. As a result, the levels of these drugs may be increased in the blood, and may cause altered effects or potentially serious adverse reactions. People using any medications should check the package insert, and speak with a qualified healthcare professional, including a pharmacist, about possible interactions.

Because soy contains estrogen like chemicals, the effects of other agents believed to have estrogen-like properties may be altered.

Soy may also potentially interact with agents for the skin, agents taken for bone health, agents taken for cancer, diarrhea, high cholesterol, heart disorders, or weight loss, agents that affect the nervous or immune system, Alzheimer's agents, antibiotics, aromatase inhibitors, calcitriol, diuretics (water pills), hormonal agents, iron salts, indomethacin, insect repellants, progestins, selective estrogen receptor modifiers (SERMs), stomach or intestine agents, thyroid hormones, tibolone.

Interactions with Herbs and Dietary Supplements

Soy may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Soy may lower blood sugar levels. Caution is advised when using herbs and supplements that may also lower blood sugar. People taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.

Soy may cause high blood pressure. Caution is advised in people taking herbs and supplements that affect blood pressure.

Soy may interfere with the way the body processes certain herbs or supplements using the liver's "cytochrome P450" enzyme system. As a result, the levels of other herbs or supplements may be altered in the blood. It may also alter the effects that other herbs or supplements possibly have on the P450 system.

Because soy contains estrogen like chemicals, the effects of other agents believed to have estrogen-like properties may be altered.

Soy may also potentially interact with Alzheimer's herbs and supplements, antibacterials, antioxidants, avocado, beta-sitosterol, black cohosh, branched-chain amino acids, calcium, diuretics (increase urine volume), flaxseed, ginseng, green tea, herbs and supplements for osteoporosis, herbs and supplements for the skin, herbs and supplements taken for cancer, diarrhea, high cholesterol, heart disorders, or weight loss, herbs and supplements that affect the nervous, digestive, or immune systems, hormonal herbs and supplements, hormonal replacement therapy, insect repellants, iron, isoflavones, lecithin, lycopene, magnesium, magnolia bark extract, manganese, oats, phosphorus, phytoprogestins, plant sterols, probiotics, resveratrol, seaweed, selenium, spirulina, thyroid hormones, vitamin C and D, zinc.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com