Before Using
Drug information provided by: Merative, Micromedex®
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Although there is no specific information comparing use of sodium thiosulfate in children with use in other age groups, this medicine is not expected to cause different side effects or problems in children than it does in adults.
Appropriate studies have not been performed on the relationship of age to the effects of Pedmark® in children younger than 1 month of age or in children with cancer that has spread (metastatic). Safety and efficacy have not been established.
Use in children younger than 1 month of age is not recommended because Pedmark® may increase the risk of hypernatremia (high sodium levels in the blood).
Geriatric
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults. Although there is no specific information comparing the use of sodium thiosulfate in the elderly with use in other age groups, this medicine is not expected to cause different side effects or problems in older people than it does in younger adults.
No information is available on the relationship of age to the effects of Pedmark® in geriatric patients.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
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Allergy to sulfites, history of or
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Asthma or
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Hypernatremia (high sodium levels in the blood) or
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Hypokalemia (low potassium levels in the blood)—Use with caution. May make these conditions worse.
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Edema (swelling of feet or lower legs) or
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Heart disease or
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High blood pressure (hypertension) or
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Kidney disease or
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Liver disease or
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Toxemia of pregnancy—Sodium thiosulfate may cause the body to retain (keep) water, which may make these conditions worse.
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Kidney disease—Use with caution. The effects may be increased because of the slower removal of the medicine from the body.
Portions of this document last updated: Feb. 01, 2024
Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.