Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of risperidone injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Elderly patients may be especially sensitive to the effects of risperidone. This may increase the chance of having side effects during treatment. This medicine should not be used for behavioral problems in older adults with dementia.

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of risperidone injection in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving risperidone injection.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bepridil
  • Bromopride
  • Cisapride
  • Dronedarone
  • Levoketoconazole
  • Levomethadyl
  • Mesoridazine
  • Metoclopramide
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abiraterone Acetate
  • Acecainide
  • Adagrasib
  • Ajmaline
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Anagrelide
  • Apalutamide
  • Apomorphine
  • Apomorphine Hydrochloride
  • Aprindine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Atazanavir
  • Azimilide
  • Azithromycin
  • Bretylium
  • Bromocriptine Mesylate
  • Buprenorphine
  • Bupropion
  • Buserelin
  • Carbamazepine
  • Ceritinib
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clothiapine
  • Clozapine
  • Crizotinib
  • Dabrafenib
  • Darunavir
  • Dasatinib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexmedetomidine
  • Dexmethylphenidate
  • Dibenzepin
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Droperidol
  • Duloxetine
  • Efavirenz
  • Encainide
  • Encorafenib
  • Enflurane
  • Entrectinib
  • Enzalutamide
  • Erythromycin
  • Escitalopram
  • Etrasimod
  • Fedratinib
  • Fenoldopam Mesylate
  • Fexinidazole
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Formoterol
  • Foscarnet
  • Fosphenytoin
  • Fostemsavir
  • Gemifloxacin
  • Gepirone
  • Ginkgo Biloba
  • Glasdegib
  • Gonadorelin
  • Goserelin
  • Halofantrine
  • Haloperidol
  • Histrelin
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Imipramine
  • Inotuzumab Ozogamicin
  • Itraconazole
  • Ivabradine
  • Ivosidenib
  • Ketoconazole
  • Lefamulin
  • Lenvatinib
  • Leuprolide
  • Levofloxacin
  • Linezolid
  • Lithium
  • Lofexidine
  • Lorcainide
  • Lumacaftor
  • Macimorelin
  • Mefloquine
  • Methylphenidate
  • Metronidazole
  • Mirtazapine
  • Mitotane
  • Mobocertinib
  • Moxifloxacin
  • Nafarelin
  • Nilotinib
  • Nortriptyline
  • Octreotide
  • Olanzapine
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Ozanimod
  • Pacritinib
  • Panobinostat
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Phenobarbital
  • Phenytoin
  • Pimavanserin
  • Pitolisant
  • Ponesimod
  • Posaconazole
  • Pramipexole Dihydrochloride
  • Primidone
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quizartinib
  • Relugolix
  • Remifentanil
  • Ribociclib
  • Rifampin
  • Rifapentine
  • Ropinirole Hydrochloride
  • Rotigotine
  • Selpercatinib
  • Sematilide
  • Serdexmethylphenidate
  • Sertindole
  • Sertraline
  • Sevoflurane
  • Simvastatin
  • Siponimod
  • Solifenacin
  • Sotalol
  • Spiramycin
  • St John's Wort
  • Sulfamethoxazole
  • Sulpiride
  • Sultopride
  • Sunitinib
  • Tacrolimus
  • Tedisamil
  • Telithromycin
  • Terbinafine
  • Tetrabenazine
  • Trazodone
  • Triclabendazole
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Vinflunine
  • Voclosporin
  • Zotepine
  • Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Cimetidine
  • Lamotrigine
  • Midodrine
  • Ranitidine
  • Ritonavir
  • Valproic Acid

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergic reaction to paliperidone (Invega®), history of—Should not be used in patients with this condition.
  • Alzheimer's disease or
  • Dehydration or
  • Heart attack, recent or history of or
  • Heart or blood vessel disease or
  • Heart failure, history of or
  • Heart rhythm problem, or a history of or
  • Hypotension (low blood pressure) or
  • Hypovolemia (low amount of blood) or
  • Stroke, history of or
  • Trouble with swallowing—May cause side effects to become worse.
  • Blood or bone marrow problems or
  • Bone problems (eg, osteodystrophy) or
  • Breast cancer, prolactin-dependent or
  • Diabetes or
  • Hyperglycemia (high blood sugar) or
  • Hyperprolactinemia (high prolactin in the blood) or
  • Neuroleptic malignant syndrome (NMS), history of or
  • Parkinson's disease or
  • Priapism (painful or prolonged erection of the penis) or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.