Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Priftin

Descriptions


Rifapentine is used in combination with other medicines to treat active tuberculosis in adults and children 12 years of age and older. It is also used to treat inactive (latent) tuberculosis in adults and children 2 years of age and older. Rifapentine is an antibiotic and works to kill or prevent the growth of bacteria. It will not help against viruses.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of rifapentine to treat active tuberculosis in children younger than 12 years of age, nor to treat inactive tuberculosis in children younger than 2 years of age. Safety and efficacy have not been established in these age groups.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rifapentine in the elderly.

Pregnancy

Information about this rifapentine-oral-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Artemether
  • Atazanavir
  • Daclatasvir
  • Delamanid
  • Lurasidone
  • Maraviroc
  • Ranolazine
  • Rilpivirine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abiraterone Acetate
  • Amprenavir
  • Apixaban
  • Apremilast
  • Aripiprazole
  • Axitinib
  • Bedaquiline
  • Bortezomib
  • Bosutinib
  • Cabozantinib
  • Ceritinib
  • Clarithromycin
  • Clozapine
  • Cobicistat
  • Dabrafenib
  • Darunavir
  • Dolutegravir
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Efavirenz
  • Eliglustat
  • Elvitegravir
  • Enzalutamide
  • Erlotinib
  • Etravirine
  • Everolimus
  • Exemestane
  • Fentanyl
  • Fosamprenavir
  • Hydrocodone
  • Ibrutinib
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ivabradine
  • Ketoconazole
  • Lapatinib
  • Ledipasvir
  • Lopinavir
  • Macitentan
  • Mifepristone
  • Naloxegol
  • Nelfinavir
  • Netupitant
  • Nevirapine
  • Nifedipine
  • Nilotinib
  • Nimodipine
  • Pazopanib
  • Perampanel
  • Piperaquine
  • Pomalidomide
  • Ponatinib
  • Quetiapine
  • Regorafenib
  • Ritonavir
  • Rivaroxaban
  • Romidepsin
  • Saquinavir
  • Simeprevir
  • Sofosbuvir
  • Sorafenib
  • Sunitinib
  • Tasimelteon
  • Ticagrelor
  • Tipranavir
  • Tofacitinib
  • Tolvaptan
  • Trabectedin
  • Ulipristal Acetate
  • Vandetanib
  • Vemurafenib
  • Vilazodone
  • Vincristine Sulfate
  • Vincristine Sulfate Liposome
  • Vinflunine
  • Vorapaxar
  • Vortioxetine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Acetyldigoxin
  • Alprazolam
  • Amiodarone
  • Amitriptyline
  • Amlodipine
  • Betamethasone
  • Bisoprolol
  • Carbamazepine
  • Carteolol
  • Carvedilol
  • Chloramphenicol
  • Chlorpropamide
  • Ciprofloxacin
  • Clofibrate
  • Cyclosporine
  • Dapsone
  • Delavirdine
  • Deslanoside
  • Desogestrel
  • Dexamethasone
  • Diazepam
  • Dicumarol
  • Dienogest
  • Digitoxin
  • Digoxin
  • Diltiazem
  • Disopyramide
  • Doxycycline
  • Drospirenone
  • Estradiol Cypionate
  • Estradiol Valerate
  • Ethinyl Estradiol
  • Ethynodiol Diacetate
  • Etonogestrel
  • Felodipine
  • Fluconazole
  • Fludrocortisone
  • Fosphenytoin
  • Gallopamil
  • Glyburide
  • Haloperidol
  • Hydrocortisone
  • Isradipine
  • Lacidipine
  • Lercanidipine
  • Levonorgestrel
  • Levothyroxine
  • Lorcainide
  • Medroxyprogesterone Acetate
  • Mestranol
  • Metildigoxin
  • Metoprolol
  • Mexiletine
  • Nicardipine
  • Nisoldipine
  • Nitrazepam
  • Nitrendipine
  • Norelgestromin
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Nortriptyline
  • Ospemifene
  • Phenprocoumon
  • Phenytoin
  • Prednisone
  • Propafenone
  • Propranolol
  • Quinidine
  • Quinine
  • Repaglinide
  • Sildenafil
  • Tacrolimus
  • Talinolol
  • Temazepam
  • Tertatolol
  • Theophylline
  • Tocainide
  • Tolbutamide
  • Triazolam
  • Valproic Acid
  • Verapamil
  • Warfarin
  • Zidovudine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse, or history of—May increase risk for more serious side effects.
  • Elevated liver enzymes or
  • Liver disease—Use with caution. May make these conditions worse.
  • Porphyria—Avoid use of rifapentine in patients with this condition.

Proper Use

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for side effects.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Take this medicine with food.

Swallow the tablet whole. Do not crush, break, or chew it.

If you cannot swallow the tablet, you may crush it and add it to a small amount of semi-solid food. Take it immediately and do not store it for later use.

To help clear up your infection completely, it is very important that you keep using this medicine for the full time of treatment, even if you begin to feel better after a few weeks. If you have TB, you might have to take rifapentine for several months. It is important that you not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For the treatment of active tuberculosis:
      • Adults and children 12 years of age and older—600 milligrams (mg) two times a week with an interval of not less than 3 days (72 hours) between doses. Then, 600 mg once a week taken for 4 months with isoniazid or other medicines.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.
    • For the treatment of latent tuberculosis:
      • Adults and children 12 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually up to 900 milligrams (mg) once a week taken with isoniazid for 12 weeks.
      • Children 2 to 11 years of age—Dose is based on body weight and must be determined by your doctor. The dose is usually 300 to 900 mg once a week taken with isoniazid for 12 weeks.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.

If your symptoms do not improve within 2 to 3 weeks, or if they become worse, check with your doctor.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor if you have a rash, itching, very fast but irregular heartbeat or pulse, hive-like swellings on the skin, fever or chills, lightheadedness, dizziness, or fainting, puffiness or swellings of the eyelids or around the eyes, or unusual bleeding, bruising, or weakness. If these side effects occur, get emergency help at once.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Liver problems may be more likely to occur if you drink alcoholic beverages regularly while you are taking this medicine. Also, the regular use of alcohol may keep this medicine from working properly. You should not drink alcoholic beverages while you are taking this medicine.

Rifapentine will cause the urine, stools, saliva, sputum, sweat, and tears to turn reddish-orange to reddish-brown. This is to be expected while you are taking this medicine. This effect may cause soft contact lenses to become permanently discolored. Standard cleaning solutions may not take out all the discoloration. It is best not to wear soft contact lenses while taking this medicine. Hard contact lenses are not discolored by rifapentine. If you have any questions about this, check with your doctor.

This medicine may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor.

Rifapentine can lower the number of white blood cells in your blood temporarily, increasing the chance of getting infection. It can also lower the number of platelets, which are necessary for proper blood clotting. These problems may result in a greater chance of getting certain infections, slow healing, and bleeding of the gums. Be careful when using a regular toothbrush, dental floss, or a toothpick. Dental work should be delayed until your blood counts have returned to normal. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment.

Before you have any medical tests, tell the doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Birth control pills may not work properly if you take them while you are taking rifapentine. Unplanned pregnancies may occur. Use a different means of birth control while you are taking rifapentine. If you have any questions about this, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Blood in the urine
  2. joint pain
  3. lower back or side pain
  4. swelling of the feet or lower legs

Less common

  1. Aggressive reaction
  2. black, tarry stools
  3. blood in the stools
  4. nausea
  5. pinpoint red spots on the skin
  6. severe abdominal or stomach pain
  7. sore throat and fever
  8. unusual bleeding or bruising
  9. unusual tiredness or weakness
  10. vomiting
  11. yellow eyes or skin

Rare

  1. Diarrhea
  2. dizziness
  3. increase in blood pressure
  4. severe or continuing headaches

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Acne
  2. constipation
  3. loss of appetite

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.