Description and Brand Names

Drug information provided by: Merative, Micromedex®

US Brand Name

  1. Inderide

Descriptions


Propranolol and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Propranolol is a beta-blocker. It works by affecting the response to some nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.

Hydrochlorothiazide is a diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of propranolol and hydrochlorothiazide combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of propranolol and hydrochlorothiazide combination in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving propranolol and hydrochlorothiazide combination.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Dofetilide
  • Fezolinetant
  • Mavorixafor
  • Rizatriptan
  • Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abametapir
  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Acetyldigoxin
  • Albiglutide
  • Albuterol
  • Alogliptin
  • Amphetamine
  • Amtolmetin Guacil
  • Arsenic Trioxide
  • Aspirin
  • Benzhydrocodone
  • Benzphetamine
  • Bromfenac
  • Bromocriptine
  • Bufexamac
  • Bupivacaine
  • Bupivacaine Liposome
  • Buprenorphine
  • Bupropion
  • Canagliflozin
  • Capmatinib
  • Cefepime
  • Celecoxib
  • Ceritinib
  • Chlorpropamide
  • Choline Salicylate
  • Clonidine
  • Clonixin
  • Codeine
  • Crizotinib
  • Dapagliflozin
  • Darunavir
  • Deslanoside
  • Desmopressin
  • Desvenlafaxine
  • Dexibuprofen
  • Dexketoprofen
  • Dextroamphetamine
  • Diatrizoate
  • Diclofenac
  • Diflunisal
  • Digitalis
  • Digitoxin
  • Digoxin
  • Dihydrocodeine
  • Diltiazem
  • Dipyrone
  • Dronedarone
  • Droperidol
  • Droxicam
  • Dulaglutide
  • Empagliflozin
  • Epinephrine
  • Escitalopram
  • Eslicarbazepine Acetate
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Exenatide
  • Fedratinib
  • Felbinac
  • Fenoldopam
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Fexinidazole
  • Fingolimod
  • Flecainide
  • Floctafenine
  • Flufenamic Acid
  • Fluoxetine
  • Flurbiprofen
  • Formoterol
  • Glimepiride
  • Glipizide
  • Glyburide
  • Haloperidol
  • Hydrocodone
  • Hydromorphone
  • Ibuprofen
  • Indacaterol
  • Indomethacin
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Bovine
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glulisine
  • Iobenguane I 131
  • Iohexol
  • Ketanserin
  • Ketoprofen
  • Ketorolac
  • Lacosamide
  • Lercanidipine
  • Levalbuterol
  • Levomethadyl
  • Lidocaine
  • Linagliptin
  • Liraglutide
  • Lisdexamfetamine
  • Lithium
  • Lixisenatide
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Meclofenamate
  • Mefenamic Acid
  • Mefloquine
  • Meloxicam
  • Meperidine
  • Mepivacaine
  • Methadone
  • Methamphetamine
  • Methotrexate
  • Metildigoxin
  • Miglitol
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Nabumetone
  • Naproxen
  • Nateglinide
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Oliceridine
  • Olodaterol
  • Ouabain
  • Oxaprozin
  • Oxymetazoline
  • Oxymorphone
  • Oxyphenbutazone
  • Parecoxib
  • Phenylbutazone
  • Piketoprofen
  • Pioglitazone
  • Piroxicam
  • Pixantrone
  • Ponesimod
  • Porfimer
  • Pramlintide
  • Prilocaine
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Proscillaridin
  • Repaglinide
  • Rifampin
  • Rivastigmine
  • Rofecoxib
  • Rosiglitazone
  • Salicylic Acid
  • Salmeterol
  • Salsalate
  • Saxagliptin
  • Simeprevir
  • Siponimod
  • Sitagliptin
  • Sodium Salicylate
  • Sotalol
  • Sparsentan
  • Sufentanil
  • Sulindac
  • Tapentadol
  • Tenoxicam
  • Terbutaline
  • Tiaprofenic Acid
  • Tolazamide
  • Tolbutamide
  • Tolfenamic Acid
  • Tolmetin
  • Topiramate
  • Tramadol
  • Valdecoxib
  • Venlafaxine
  • Verapamil
  • Vilanterol
  • Vildagliptin
  • Vonoprazan
  • Vorasidenib
  • Warfarin
  • Zileuton

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Acetyldigoxin
  • Albiglutide
  • Alfuzosin
  • Alogliptin
  • Aluminum Carbonate, Basic
  • Aluminum Hydroxide
  • Aluminum Phosphate
  • Aminolevulinic Acid
  • Amtolmetin Guacil
  • Aspirin
  • Bepridil
  • Bromfenac
  • Bufexamac
  • Bunazosin
  • Calcium Carbonate
  • Canagliflozin
  • Carbamazepine
  • Celecoxib
  • Chlorpromazine
  • Chlorpropamide
  • Cholestyramine
  • Choline Salicylate
  • Cimetidine
  • Clonixin
  • Dapagliflozin
  • Deslanoside
  • Dexibuprofen
  • Dexketoprofen
  • Diclofenac
  • Diflunisal
  • Digitoxin
  • Digoxin
  • Dihydroergotamine
  • Dihydroxyaluminum Aminoacetate
  • Dihydroxyaluminum Sodium Carbonate
  • Dipyrone
  • Doxazosin
  • Droxicam
  • Dulaglutide
  • Empagliflozin
  • Ergotamine
  • Ertugliflozin
  • Etodolac
  • Etofenamate
  • Etoricoxib
  • Exenatide
  • Felbinac
  • Fenoprofen
  • Fepradinol
  • Feprazone
  • Flecainide
  • Floctafenine
  • Flufenamic Acid
  • Flurbiprofen
  • Fluvoxamine
  • Ginkgo
  • Glimepiride
  • Glipizide
  • Glyburide
  • Gossypol
  • Ibuprofen
  • Indomethacin
  • Insulin Aspart, Recombinant
  • Insulin Degludec
  • Insulin Detemir
  • Insulin Glargine, Recombinant
  • Insulin Glulisine
  • Insulin Human Inhaled
  • Insulin Human Isophane (NPH)
  • Insulin Human Regular
  • Insulin Lispro, Recombinant
  • Ketoprofen
  • Ketorolac
  • Licorice
  • Linagliptin
  • Liraglutide
  • Lixisenatide
  • Lornoxicam
  • Loxoprofen
  • Lumiracoxib
  • Magaldrate
  • Meclofenamate
  • Mefenamic Acid
  • Meloxicam
  • Metformin
  • Metildigoxin
  • Miglitol
  • Morniflumate
  • Moxisylyte
  • Nabumetone
  • Naproxen
  • Nateglinide
  • Nepafenac
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Oxaprozin
  • Oxyphenbutazone
  • Parecoxib
  • Phenoxybenzamine
  • Phentolamine
  • Phenylbutazone
  • Piketoprofen
  • Pioglitazone
  • Piroxicam
  • Pramlintide
  • Pranoprofen
  • Prazosin
  • Proglumetacin
  • Propyphenazone
  • Proquazone
  • Quinidine
  • Repaglinide
  • Rifapentine
  • Rofecoxib
  • Rosiglitazone
  • Salicylic Acid
  • Salsalate
  • Saxagliptin
  • Sitagliptin
  • Sodium Salicylate
  • St John's Wort
  • Sulindac
  • Tamsulosin
  • Tenoxicam
  • Terazosin
  • Tiaprofenic Acid
  • Tolazamide
  • Tolbutamide
  • Tolfenamic Acid
  • Tolmetin
  • Trimazosin
  • Urapidil
  • Valdecoxib
  • Vildagliptin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Tobacco

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Angina (severe chest pain)—May provoke chest pain if stopped too quickly.
  • Anuria (not able to form urine) or
  • Asthma or
  • Bradycardia (slow heartbeat) or
  • Cardiogenic shock (shock caused by heart attack) or
  • Congestive heart failure or
  • Heart block or
  • Sulfa drug allergy (eg, sulfamethoxazole, Bactrim®, Septra®)—Should not be used in patients with these conditions.
  • Diabetes or
  • Hyperthyroidism (overactive thyroid) or
  • Hypoglycemia (low blood sugar)—May cover up some of the signs and symptoms of these diseases, such as a fast heartbeat.
  • Electrolyte imbalance (eg, hypercalcemia, hypokalemia, hypomagnesemia, hyponatremia) or
  • Glaucoma, secondary angle closure or
  • Gout or
  • Hyperuricemia (high uric acid in the blood) or
  • Liver disease or
  • Myopia, acute (changes in the eyeball causing vision problems) or
  • Systemic lupus erythematosus (SLE)—Use with caution. May make these conditions worse.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
  • Lung disease (eg, bronchitis, emphysema)—May cause difficulty with breathing in patients with this condition.
  • Sympathectomy—Use with caution. The effects of this medicine may be increased.
  • Wolff-Parkinson-White syndrome (rare heart condition)—May cause very slow heartbeat in patients with this condition.

Proper Use

This medicine should not be the first medicine you use to treat your condition. It is meant to be used only after you have tried other medicines that have not worked or have caused unwanted side effects.

In addition to the use of this medicine, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium. Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Swallow the tablet whole. Do not crush, break, or chew it.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For high blood pressure:
      • Adults—One tablet two times a day. Your doctor may adjust your dose if needed.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

This medicine may cause serious allergic reactions including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, lips, tongue, or throat while you are using this medicine.

This medicine may cause or worsen heart failure in some patients. Check with your doctor right away if you are having chest pain or discomfort, dilated neck veins, extreme fatigue, irregular breathing, an irregular heartbeat, swelling of the face, fingers, feet, or lower legs, trouble breathing, or weight gain.

Do not interrupt or stop taking this medicine without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous.

This medicine may cause changes in your blood sugar levels. Also, this medicine may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.

Serious skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme) can occur during treatment with this medicine. Check with your doctor right away if you start having skin itching, swelling, rash, or redness, blistering, peeling, or loosening of the skin, or any other unusual effects that may be caused by this medicine.

Check with your doctor right away if you start having dry mouth, increased thirst, muscle cramps, nausea or vomiting, unusual tiredness or weakness, severe drowsiness or dizziness, seizures, a decrease in urine, or a fast heartbeat while you are using this medicine. These may be symptoms of dehydration or mineral imbalance.

Check with your doctor immediately if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem. Your doctor will want you to have your eyes checked by an ophthalmologist (eye doctor).

This medicine may increase your risk of getting skin cancer (eg, non-melanoma skin cancer). Avoid sun exposure. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. Talk to your doctor if you have concerns about this risk.

Alcohol, narcotic pain relievers, or sleeping pills may cause you to feel more lightheaded, dizzy, or faint when used with this medicine. Tell your doctor if you are drinking alcohol or using pain relievers or sleeping pills.

Do not take other medicines unless they have been discussed with your doctor. This especially includes prescription or nonprescription (over-the-counter) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may increase your blood pressure.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

  1. Black, tarry stools
  2. bleeding gums
  3. blistering, peeling, or loosening of the skin
  4. bloating
  5. blood in the urine
  6. bloody nose
  7. bloody stools
  8. blurred or loss of vision
  9. body aches or pain
  10. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  11. chest pain, discomfort, or tightness
  12. clay-colored stools
  13. cold sweats
  14. confusion about identity, place, and time
  15. congestion
  16. constipation
  17. cough
  18. coughing up blood
  19. cracks in the skin
  20. crying
  21. darkened urine
  22. decreased awareness or responsiveness
  23. decreased urine output
  24. depersonalization
  25. diarrhea
  26. difficulty with breathing or swallowing
  27. dilated neck veins
  28. disturbed color perception
  29. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  30. double vision
  31. dry mouth
  32. dryness or soreness of the throat
  33. dysphoria
  34. false or unusual sense of well-being
  35. fast, pounding, slow, or irregular heartbeat
  36. fever or chills
  37. flushing or redness of the skin
  38. fruit-like breath odor
  39. general feeling of discomfort or illness
  40. general feeling of tiredness or weakness
  41. hair loss
  42. halos around lights
  43. headaches
  44. heavier menstrual periods
  45. hives or welts, itching
  46. hoarseness
  47. increased hunger
  48. increased sensitivity of the skin to sunlight
  49. increased thirst
  50. increased urination
  51. indigestion
  52. irregular breathing
  53. irregular heartbeat
  54. joint pain, stiffness, or swelling
  55. lightheadedness, dizziness, or fainting
  56. loss of appetite
  57. loss of heat from the body
  58. loss of strength or energy
  59. lower back or side pain
  60. mental depression
  61. mimicry of speech or movements
  62. muscle pain or weakness
  63. mutism
  64. nausea or vomiting
  65. negativism
  66. night blindness
  67. noisy breathing
  68. overbright appearance of lights
  69. painful or difficult urination
  70. pains in the stomach, side, or abdomen, possibly radiating to the back
  71. paleness or cold feeling in the fingertips and toes
  72. paranoia
  73. peculiar postures or movements, mannerisms or grimacing
  74. persistent non-healing sore
  75. pink growth
  76. pinpoint red or purple spots on the skin
  77. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  78. quick to react or overreact emotionally
  79. rapidly changing moods
  80. rectal bleeding
  81. red skin lesions, often with a purple center
  82. red, irritated eyes
  83. red, swollen skin
  84. reddening of the skin, especially around the ears
  85. reddish patch or irritated area
  86. runny nose
  87. scaly skin
  88. seeing, hearing, or feeling things that are not there
  89. severe sleepiness
  90. severe sunburn
  91. shiny bump
  92. short-term memory loss
  93. skin irritation or rash, including rash that looks like psoriasis
  94. sleeplessness
  95. sore throat
  96. sores, ulcers, or white spots on the lips or in the mouth
  97. stomach pain or tenderness
  98. sugar in the urine
  99. sweating
  100. swelling of the eyes, face, or inside of the nose
  101. swelling of the fingers, feet, or lower legs
  102. tender, swollen, or painful glands in the neck
  103. tenderness of salivary glands
  104. tenderness, burning, or peeling of the skin
  105. thickening of bronchial secretions
  106. tingling or pain in the fingers or toes when exposed to cold
  107. trouble breathing
  108. trouble with sleeping
  109. trouble with swallowing
  110. tunnel vision
  111. unable to sleep
  112. unpleasant breath odor
  113. unusual bleeding or bruising
  114. unusual tiredness or weakness
  115. unusual weight loss
  116. unusually warm skin
  117. voice changes
  118. vomiting of blood
  119. weight gain
  120. white, yellow or waxy scar-like area
  121. yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Change in consciousness
  2. decreased urination
  3. fast, slow, or shallow breathing
  4. gas
  5. heartburn
  6. increase in heart rate
  7. increased sweating
  8. indigestion
  9. loss of consciousness
  10. low blood pressure
  11. muscle cramps
  12. pale or blue lips, fingernails, or skin
  13. rapid breathing
  14. seizures
  15. sunken eyes
  16. unusual drowsiness, dullness, or feeling of sluggishness
  17. unusual paleness
  18. weakness and heaviness of the legs
  19. wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  1. Decreased interest in sexual intercourse
  2. dry eyes
  3. feeling of constant movement of self or surroundings
  4. inability to have or keep an erection
  5. loss in sexual ability, desire, drive, or performance
  6. muscle spasm
  7. pain of the penis on erection
  8. pain or discomfort in the chest, upper stomach, or throat
  9. restlessness
  10. sensation of spinning
  11. stomach cramps
  12. thinning of the hair
  13. vivid dreams

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.