Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Aloxi

Descriptions


Palonosetron injection is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy). It is also used to prevent nausea and vomiting that may occur after surgery. Palonosetron works by blocking the signals to the brain that cause nausea and vomiting.

This medicine is to be given only by or under the direct supervision of your doctor.

This product is available in the following dosage forms:

  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of palonosetron injection to prevent nausea and vomiting that is caused by cancer medicines in children. However, safety and efficacy have not been established in children younger than 1 month of age.

Appropriate studies have not been performed on the relationship of age to the effects of palonosetron injection to prevent nausea and vomiting that may occur after surgery in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of palonosetron injection in the elderly.

Pregnancy

Information about this palonosetron-intravenous-route
Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Apomorphine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use

You will receive this medicine while you or your child are in a hospital or cancer treatment center. A nurse or other trained health professional will give you or your child this medicine. This medicine is given through a needle placed in one of your veins.

This medicine is usually given about 30 minutes before the start of chemotherapy or right before you or your child receives anesthetic medicine for surgery.

This medicine should come with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Precautions

Check with your doctor if severe nausea and vomiting continue after leaving the hospital or cancer treatment center.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you or your child have a rash, a fast heartbeat, fever, hives, itching, irritation, hoarseness, joint pain, stiffness or swelling, rash, redness of the skin, swelling of the eyelids, face, lips, hands, or feet, tightness in the chest, or trouble breathing or swallowing after receiving this medicine.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

  1. Blurred vision
  2. chest pain or discomfort
  3. confusion
  4. difficult breathing
  5. dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  6. fainting
  7. fever
  8. irregular heartbeats that continue
  9. sweating
  10. unusual tiredness or weakness

Rare

  1. Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  2. extra heartbeats
  3. nervousness
  4. pain in the shoulders, arms, jaw, or neck
  5. pounding in the ears
  6. slow or fast heartbeat

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Bluish color of the fingernails, lips, skin, palms, or nail beds
  2. collapse
  3. gasping to breathe
  4. paleness of the skin
  5. seizures

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Difficulty having a bowel movement (stool)
  2. headache

Less common

  1. Acid or sour stomach
  2. belching
  3. bloated or full feeling
  4. blood in the urine
  5. bloody or black, tarry stools
  6. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  7. change in vision
  8. chills
  9. continuing ringing or buzzing
  10. cough
  11. decrease in frequency of urination
  12. decrease in urine volume
  13. deep breathing
  14. diarrhea
  15. difficulty in passing urine
  16. drowsiness
  17. dry mouth
  18. excess air or gas in the stomach or intestines
  19. excessive sleeping
  20. eye irritation
  21. fear
  22. feeling happy
  23. feeling of warmth
  24. flushed dry skin
  25. fruit-like breath odor
  26. general feeling of discomfort or illness
  27. hearing loss
  28. heartburn
  29. hiccups
  30. impaired vision
  31. increased hunger
  32. increased thirst
  33. increased urination
  34. indigestion
  35. joint pain
  36. large, flat, blue or purplish patches in the skin
  37. loss of appetite
  38. muscle aches and pains
  39. muscle tremors
  40. numbness or tingling in the hands, feet, or lips
  41. painful knees and ankles
  42. painful urination
  43. passing gas
  44. raised red swellings on the skin, the buttocks, legs or ankles
  45. rash
  46. red, sore eyes
  47. redness of the face, neck, arms, and occasionally, upper chest
  48. restlessness
  49. runny nose
  50. shivering
  51. sore throat
  52. stomach discomfort, upset, or pain
  53. sugar in the urine
  54. swelling or protruding veins
  55. trembling
  56. trouble sleeping
  57. unexplained noise in the ears
  58. unexplained weight loss
  59. unusually deep sleep
  60. unusually long duration of sleep
  61. vein discoloration
  62. weakness or heaviness of the legs

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.