Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Endodan
  2. Percodan

Descriptions


Oxycodone and aspirin combination is used to relieve moderate to moderately severe pain. Oxycodone belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain.

Aspirin is used to relieve pain and reduce fever in patients. Aspirin belongs to the group of medicines known as salicylates and acts on the immune system to reduce inflammation. It is also known as an anti-inflammatory analgesic.

When oxycodone is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of oxycodone and aspirin combination in the pediatric population. Because of aspirin's toxicity, use in children and teenagers is not recommended.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of oxycodone and aspirin combination in the elderly. However, elderly patients are more likely to have age-related liver or kidney problems, which may require caution and an adjustment in the dose for patients receiving oxycodone and aspirin combination.

Pregnancy

Information about this oxycodone-and-aspirin-oral-route
Pregnancy Category Explanation
All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breastfeeding

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Breastfeeding

Breastfeeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Influenza Virus Vaccine, Live
  • Ketorolac
  • Naltrexone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abciximab
  • Acenocoumarol
  • Acetophenazine
  • Adinazolam
  • Alfentanil
  • Alipogene Tiparvovec
  • Alprazolam
  • Alteplase, Recombinant
  • Amobarbital
  • Anagrelide
  • Anileridine
  • Anisindione
  • Apixaban
  • Ardeparin
  • Argatroban
  • Atazanavir
  • Beta Glucan
  • Bivalirudin
  • Brofaromine
  • Bromazepam
  • Brotizolam
  • Buprenorphine
  • Buspirone
  • Butabarbital
  • Butalbital
  • Butorphanol
  • Carbinoxamine
  • Carisoprodol
  • Certoparin
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlorpromazine
  • Chlorzoxazone
  • Cilostazol
  • Citalopram
  • Clarithromycin
  • Clobazam
  • Clonazepam
  • Clopidogrel
  • Clopidogrel Hydrogen Sulfate
  • Clorazepate
  • Clorgyline
  • Clovoxamine
  • Codeine
  • Crizotinib
  • Cyclosporine
  • Dabigatran Etexilate
  • Dabrafenib
  • Dalteparin
  • Danaparoid
  • Dantrolene
  • Desflurane
  • Desirudin
  • Desvenlafaxine
  • Dexmedetomidine
  • Dezocine
  • Diazepam
  • Dicumarol
  • Diphenhydramine
  • Dipyridamole
  • Doxylamine
  • Duloxetine
  • Enflurane
  • Enoxaparin
  • Eptifibatide
  • Erlotinib
  • Erythromycin
  • Escitalopram
  • Eslicarbazepine Acetate
  • Estazolam
  • Eszopiclone
  • Ethchlorvynol
  • Ethopropazine
  • Femoxetine
  • Fentanyl
  • Feverfew
  • Flesinoxan
  • Flumazenil
  • Flunitrazepam
  • Fluoxetine
  • Fluphenazine
  • Flurazepam
  • Fluvoxamine
  • Fondaparinux
  • Fospropofol
  • Furazolidone
  • Ginkgo
  • Gossypol
  • Halazepam
  • Halothane
  • Heparin
  • Hydrocodone
  • Hydromorphone
  • Hydroxyzine
  • Indinavir
  • Iproniazid
  • Isocarboxazid
  • Isoflurane
  • Itraconazole
  • Ketamine
  • Ketazolam
  • Ketoconazole
  • Ketoprofen
  • Lazabemide
  • Lepirudin
  • Levomilnacipran
  • Levorphanol
  • Linezolid
  • Lorazepam
  • Lormetazepam
  • Meadowsweet
  • Meclizine
  • Medazepam
  • Meperidine
  • Mephenesin
  • Mephobarbital
  • Meprobamate
  • Meptazinol
  • Mesoridazine
  • Metaxalone
  • Methdilazine
  • Methocarbamol
  • Methohexital
  • Methotrexate
  • Midazolam
  • Milnacipran
  • Moclobemide
  • Morphine
  • Morphine Sulfate Liposome
  • Nadroparin
  • Nalbuphine
  • Naproxen
  • Nefazodone
  • Nelfinavir
  • Nialamide
  • Nitrazepam
  • Nitrous Oxide
  • Nordazepam
  • Opium
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Pargyline
  • Parnaparin
  • Paroxetine
  • Pemetrexed
  • Pentazocine
  • Pentobarbital
  • Pentosan Polysulfate Sodium
  • Pentoxifylline
  • Perphenazine
  • Phenelzine
  • Phenindione
  • Phenobarbital
  • Phenprocoumon
  • Piperaquine
  • Pralatrexate
  • Prasugrel
  • Prazepam
  • Primidone
  • Procarbazine
  • Prochlorperazine
  • Promazine
  • Promethazine
  • Propiomazine
  • Propofol
  • Propoxyphene
  • Protein C
  • Quazepam
  • Ramelteon
  • Rasagiline
  • Remifentanil
  • Reteplase, Recombinant
  • Reviparin
  • Ritonavir
  • Rivaroxaban
  • Saquinavir
  • Secobarbital
  • Selegiline
  • Sertraline
  • Sevoflurane
  • Sibutramine
  • Sodium Oxybate
  • Sufentanil
  • Tacrolimus
  • Tapentadol
  • Telithromycin
  • Temazepam
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Toloxatone
  • Tranylcypromine
  • Treprostinil
  • Triazolam
  • Trifluoperazine
  • Triflupromazine
  • Trimeprazine
  • Varicella Virus Vaccine
  • Venlafaxine
  • Vilazodone
  • Vortioxetine
  • Warfarin
  • Zaleplon
  • Zimeldine
  • Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acebutolol
  • Acetohexamide
  • Alacepril
  • Alprenolol
  • Amiloride
  • Amlodipine
  • Anagrelide
  • Arotinolol
  • Atenolol
  • Azilsartan Medoxomil
  • Azosemide
  • Befunolol
  • Bemetizide
  • Benazepril
  • Bendroflumethiazide
  • Benzthiazide
  • Bepridil
  • Betamethasone
  • Betaxolol
  • Bevantolol
  • Bisoprolol
  • Bopindolol
  • Bucindolol
  • Bumetanide
  • Bupranolol
  • Buthiazide
  • Candesartan Cilexetil
  • Canrenoate
  • Captopril
  • Carteolol
  • Carvedilol
  • Celecoxib
  • Celiprolol
  • Chlorothiazide
  • Chlorpropamide
  • Chlorthalidone
  • Cilazapril
  • Clopamide
  • Cortisone
  • Cyclopenthiazide
  • Deflazacort
  • Delapril
  • Desvenlafaxine
  • Dexamethasone
  • Dilevalol
  • Diltiazem
  • Enalaprilat
  • Enalapril Maleate
  • Eprosartan
  • Esmolol
  • Ethacrynic Acid
  • Felodipine
  • Flunarizine
  • Fosinopril
  • Furosemide
  • Gallopamil
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Hydrochlorothiazide
  • Hydroflumethiazide
  • Ibuprofen
  • Imidapril
  • Indapamide
  • Irbesartan
  • Isradipine
  • Labetalol
  • Lacidipine
  • Landiolol
  • Levobetaxolol
  • Levobunolol
  • Lidoflazine
  • Lisinopril
  • Losartan
  • Manidipine
  • Mepindolol
  • Methyclothiazide
  • Methylprednisolone
  • Metipranolol
  • Metolazone
  • Metoprolol
  • Miconazole
  • Moexipril
  • Nadolol
  • Nebivolol
  • Nicardipine
  • Nifedipine
  • Nilvadipine
  • Nimodipine
  • Nipradilol
  • Nisoldipine
  • Nitrendipine
  • Nitroglycerin
  • Olmesartan Medoxomil
  • Oxprenolol
  • Paramethasone
  • Penbutolol
  • Pentopril
  • Perampanel
  • Perindopril
  • Pindolol
  • Piretanide
  • Polythiazide
  • Pranidipine
  • Prednisolone
  • Prednisone
  • Probenecid
  • Propranolol
  • Quinapril
  • Ramipril
  • Rifampin
  • Rofecoxib
  • Sotalol
  • Spirapril
  • Spironolactone
  • St John's Wort
  • Streptokinase
  • Talinolol
  • Tamarind
  • Tasosartan
  • Telmisartan
  • Temocapril
  • Tenecteplase
  • Tertatolol
  • Timolol
  • Tolazamide
  • Tolbutamide
  • Torsemide
  • Trandolapril
  • Triamcinolone
  • Triamterene
  • Trichlormethiazide
  • Valproic Acid
  • Valsartan
  • Verapamil
  • Voriconazole
  • Xipamide
  • Zofenopril

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Addison's disease (adrenal gland problem) or
  • Alcohol abuse, or history of or
  • Bleeding problems or
  • Brain tumor, history of or
  • Chronic obstructive pulmonary disease (COPD) or
  • Cor pulmonale (serious heart condition) or
  • Drug dependence, especially with narcotics, or history of or
  • Enlarged prostate (BPH, prostatic hypertrophy) or
  • Gallbladder disease or gallstones or
  • Head injuries, history of or
  • Hypothyroidism (an underactive thyroid) or
  • Hypovolemia (low blood volume) or
  • Kyphoscoliosis (curvature of the spine with breathing problems) or
  • Peptic ulcer disease, active or history of or
  • Problems with passing urine or
  • Vitamin K deficiency—Use with caution. May increase risk for more serious side effects.
  • Asthma with nasal polyps and rhinitis, history of or
  • Asthma, severe or
  • Breathing problems, severe (e.g., hypoxia) or
  • Hemophilia (a bleeding problem) or
  • Paralytic ileus (intestine stops working and may be blocked) or
  • Respiratory depression (very slow breathing)—Should not be used in patients with these conditions.
  • Hypotension (low blood pressure) or
  • Pancreatitis (inflammation of the pancreas) or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Kidney disease or
  • Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This is especially important for elderly patients, who may be more sensitive to the effects of pain medicines. If too much of this medicine is taken for a long time, it may become habit-forming (causing mental or physical dependence).

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For moderate to moderately severe pain:
      • Adults—One tablet every 6 hours as needed. Your doctor may adjust your dose if needed. However, the dose is usually not more than 12 tablets per day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Flush the unused Percodan® oral tablets down the toilet.

Precautions

It is very important that your doctor check your progress while you are taking this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine will add to the effects of alcohol and other CNS depressants (medicines that can make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; other prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Also, there may be a higher risk of bleeding problems if you drink three or more alcoholic beverages per day while you are taking aspirin. Do not drink alcoholic beverages, and check with your doctor before taking any of these medicines while you are using this medicine.

This medicine may be habit-forming. If you feel that the medicine is not working as well, do not use more than your prescribed dose. Call your doctor for instructions.

Dizziness, lightheadedness, or fainting may occur when you get up suddenly from a lying or sitting position. Getting up slowly may help lessen this problem. Also, lying down for a while may relieve the dizziness or lightheadedness.

This medicine may make you dizzy, drowsy, or lightheaded. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Using narcotics for a long time can cause severe constipation. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems.

Check with your doctor right away if you have the following symptoms while using this medicine: acid or sour stomach; bloody or black, tarry stools; heartburn; nausea; vomiting; stomach pain; or vomiting of blood or material that looks like coffee grounds.

This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.

If you have been using this medicine regularly for several weeks or longer, do not change your dose or suddenly stop using it without checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, such as abdominal or stomach cramps, anxiety, fever, nausea, runny nose, sweating, tremors, or trouble with sleeping.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

  1. Abdominal pain, cramping, or tenderness
  2. agitation
  3. bleeding gums
  4. bloating
  5. blood in the urine or stools
  6. bloody, black, or tarry stools
  7. blue lips, fingernails, or skin
  8. blurred vision
  9. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  10. change in consciousness or confusion
  11. chest pain or discomfort
  12. chills
  13. clay-colored stools
  14. constipation
  15. convulsions
  16. coughing or vomiting blood
  17. dark-colored urine
  18. decrease in urine volume or frequency
  19. decreased appetite
  20. depression
  21. difficult, fast, noisy breathing, sometimes with wheezing
  22. difficulty in passing urine (dribbling)
  23. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  24. drowsiness
  25. dry mouth
  26. fainting
  27. fast, slow, irregular, pounding, or racing heartbeat or pulse
  28. feeling of hostility or irritability
  29. feeling of warmth
  30. feeling that something terrible will happen
  31. fever
  32. headache, sudden, severe
  33. heartburn
  34. hives or itching
  35. increased menstrual flow or vaginal bleeding
  36. increased sweating
  37. indigestion
  38. irregular, fast, slow, or shallow breathing
  39. large, flat, blue or purplish patches in the skin
  40. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  41. loss of consciousness
  42. low body temperature
  43. muscle cramping, weakness, or tremors
  44. muscle pain or stiffness
  45. nausea or vomiting
  46. nosebleeds
  47. numbness or tingling in the hands, feet, or lips
  48. painful or difficult urination
  49. pains in the stomach, side, or abdomen, possibly radiating to the back
  50. pale skin
  51. pinpoint red or purple spots on the skin
  52. prolonged bleeding from cuts
  53. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  54. red or black, tarry stools or dark urine
  55. restlessness
  56. shivering
  57. shortness of breath
  58. skin rash
  59. sleepiness
  60. sunken eyes
  61. sweating
  62. swelling of face, ankles, hands, feet, or lower legs
  63. thirst
  64. tightness in the chest
  65. unusual bleeding or bruising
  66. unusual tiredness or weakness
  67. vomiting of material that looks like coffee grounds, severe and continuing
  68. weak or feeble pulse
  69. weakness or heaviness of the legs
  70. weight gain
  71. wheezing
  72. wrinkled skin
  73. yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Continuing ringing or buzzing or other unexplained noise in the ears
  2. decreased awareness or responsiveness
  3. diarrhea
  4. drowsiness
  5. enlarged pupils
  6. extremely high fever or body temperature
  7. fast, weak heartbeat
  8. hearing loss
  9. increase in heart rate
  10. restlessness
  11. severe sleepiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Relaxed and calm feeling
  2. sleepiness

Incidence not known

  1. Belching
  2. bloated, full feeling
  3. blurred or loss of vision
  4. change in color perception
  5. cold sweats
  6. constricted, pinpoint, or small pupils (black part of the eye)
  7. cool, pale skin
  8. double vision
  9. excess air or gas in the stomach
  10. false or unusual sense of well-being
  11. flushed, dry skin
  12. fruit-like breath odor
  13. halos around lights
  14. increased hunger or thirst
  15. increased urination
  16. lack or loss of strength
  17. night blindness
  18. nightmares
  19. overbright appearance of lights
  20. red eyes
  21. redness of the skin
  22. seeing, hearing, or feeling things that are not there
  23. shakiness
  24. sleepiness or unusual drowsiness
  25. slurred speech
  26. trouble sleeping
  27. tunnel vision
  28. unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness
  29. weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.