Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Eloxatin

Descriptions


Oxaliplatin injection is given along with other medicines to treat advanced cancer of the colon or rectum. It is also used to treat severe colon cancer in patients who have had a surgery.

Oxaliplatin belongs to the group of medicines called antineoplastics. It interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Some of these may be serious and must be reported to your doctor. Other effects may not be serious but may cause concern. Some effects may occur after treatment with oxaliplatin has been stopped. Be sure that you have discussed with your doctor the possible side effects of this medicine as well as the benefits it can do.

This medicine is to be given only by or under the direct supervision of a doctor.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, oxaliplatin is used in certain patients with the following medical conditions:

  • Colon cancer, stage II, adjuvant treatment in combination with 5-fluorouracil/leucovorin.
  • Gastric carcinoma, advanced or metastatic.
  • Metastatic colorectal cancer (cancer of the colon or rectum that has spread to other areas of the body), first-line therapy, in combination with bevacizumab and capecitabine.
  • Metastatic pancreatic adenocarcinoma (cancer of the pancreas that has spread to other areas of the body), first-line treatment, in combination with 5-fluorouracil, leucovorin, and irinotecan.

This product is available in the following dosage forms:

  • Solution
  • Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of oxaliplatin injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of oxaliplatin injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution in patients receiving oxaliplatin injection.

Pregnancy

Information about this oxaliplatin-intravenous-route
Pregnancy Category Explanation
All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Rotavirus Vaccine, Live

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adenovirus Vaccine Type 4, Live
  • Adenovirus Vaccine Type 7, Live
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Influenza Virus Vaccine, Live
  • Measles Virus Vaccine, Live
  • Mumps Virus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Smallpox Vaccine
  • Typhoid Vaccine
  • Varicella Virus Vaccine
  • Yellow Fever Vaccine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Kidney disease—Effects of oxaliplatin may be increased because of slower removal from the body.
  • Liver disease or
  • Lung disease or
  • Peripheral neuropathy (nerve problem)—Use with caution. May make these conditions worse.

Proper Use

This medicine often causes nausea and vomiting. However, it is very important that you continue to receive this medicine even if you begin to feel ill. Other medicines may be given to you to help with the nausea and vomiting. Ask your doctor for other ways to lessen these effects.

You will receive this medicine while you are in a hospital or cancer treatment center. A doctor or other trained health professional will give you this medicine. This medicine is given through a needle placed into one of your veins.

If any of this medicine gets on your skin or in your eyes, nose, or mouth, tell your doctor or nurse right away.

Oxaliplatin is usually used with other medicines to treat cancer. This combination of medicines is usually given for 2 days, but you will receive oxaliplatin on the first day only (day 1). This 2-day treatment is given again every 14 days until your body responds to the medicine.

This medicine comes with a patient information leaflet. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Precautions

It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Make sure your doctor knows if you are pregnant before you receive this medicine. Using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, diarrhea, a fever or chills, hives, hoarseness, itching, lightheadedness or dizziness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you receive the medicine.

While you are being treated with oxaliplatin, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Oxaliplatin may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have taken oral polio vaccine within the last several months. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.

Oxaliplatin can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding:

  • If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination, and persistent diarrhea.
  • Check with your doctor immediately if you have persistent vomiting, diarrhea, dehydration, cough, or difficulty breathing.
  • Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
  • Check with your doctor immediately if you notice any redness, pain, or swelling in the area you are receiving your medicine.
  • Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.
  • Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.
  • Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters.
  • Avoid contact sports or other situations where bruising or injury could occur.

Stop using this medicine and check with your doctor right away if you start having cough, shortness of breath, or any problems with breathing. These may be signs of a serious lung disease.

Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral or sensory neuropathy.

Avoid cold drinks, and the use of ice cubes in drinks. Avoid cold temperatures and cold objects. Cover your skin if you must go outside in cold temperatures. Do not put ice or ice packs on your body. Do not breathe deeply when exposed to cold air. Do not take things from the freezer or refrigerator without wearing gloves. Do not run the air conditioner at high levels in the house or in the car in hot weather.

This medicine may increase your chance of having blood clots or a brain condition called reversible posterior leukoencephalopathy syndrome (RPLS). Stop using this medicine and tell your doctor right away if you develop sudden and severe headaches, fainting spells, seizures, unusual drowsiness, confusion, or problems with vision, speech, or walking while you are using this medicine.

This medicine may cause blurred vision or other vision problems. If any of these occur, do not drive, use machines, or do anything else that could be dangerous if you are not able to see well. If these reactions are especially bothersome, check with your doctor.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Abnormal tongue sensation
  2. black, tarry stools
  3. bleeding gums
  4. blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet
  5. blood in the urine or stools
  6. burning, prickling, itching, or tingling of the skin
  7. chest pain
  8. chills
  9. confusion
  10. cough
  11. decreased feeling, or pain in the hands, feet, around the mouth, or throat
  12. decreased urination
  13. difficulty performing daily activities such as writing, buttoning, swallowing, or walking
  14. difficulty with articulating words
  15. difficulty with breathing
  16. difficulty with moving
  17. difficulty with swallowing
  18. dizziness
  19. dry mouth
  20. eye pain
  21. fainting
  22. fever
  23. increase in heart rate
  24. jaw spasm
  25. lightheadedness
  26. muscle pain or stiffness
  27. numbness
  28. numbness, pain, tingling, or unusual sensations in the palms of the hands or bottoms of the feet
  29. pain in the chest, groin, or legs, especially the calves
  30. pain in the joints
  31. painful or difficult urination
  32. pale skin
  33. pinpoint red spots on the skin
  34. rapid breathing
  35. sensation of pins and needles
  36. severe, sudden headache
  37. shortness of breath
  38. slurred speech
  39. sore throat
  40. sores, ulcers, or white spots on the lips or in the mouth
  41. stabbing pain
  42. sudden loss of coordination
  43. sudden, severe weakness or numbness in the arm or leg
  44. sudden, unexplained shortness of breath
  45. sunken eyes
  46. swelling
  47. swelling or inflammation of the mouth
  48. swollen glands
  49. thirst
  50. troubled breathing with exertion
  51. unusual bleeding or bruising
  52. unusual tiredness or weakness
  53. vision changes
  54. wrinkled skin

Less common

  1. Convulsions
  2. fast heartbeat
  3. hives
  4. increased thirst
  5. irregular heartbeat
  6. itching
  7. loss of appetite
  8. mood changes
  9. nausea or vomiting
  10. numbness or tingling in the hands, feet, or lips
  11. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  12. skin rash
  13. tightness in the chest
  14. wheezing

Incidence not known

  1. Back, leg, or stomach pains
  2. blindness
  3. bloated abdomen
  4. blue-yellow color blindness
  5. blurred vision
  6. changes in patterns and rhythms of speech
  7. dark urine
  8. deafness
  9. decreased vision
  10. deep breathing
  11. drowsiness
  12. electric shock-like sensation that moves down the back and into the legs following a bending movement of the neck
  13. general body swelling
  14. increased urination
  15. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  16. loss of deep tendon reflexes
  17. muscle tremors
  18. pain and fullness in the right upper abdomen
  19. restlessness
  20. severe constipation
  21. severe diarrhea
  22. severe nosebleeds
  23. severe stomach cramps or tenderness
  24. severe vomiting
  25. trouble with speaking
  26. twitches of the muscle visible under the skin
  27. weakness of the muscles in your face
  28. weight gain
  29. yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Agitation
  2. coma
  3. cough or hoarseness
  4. diarrhea
  5. disorientation
  6. involuntary, rapid, or rhythmic movement of the eyes
  7. lack of coordination
  8. lack of sensation
  9. lethargy
  10. lower back or side pain
  11. paralysis
  12. respiratory failure
  13. seizures
  14. severe weakness
  15. slow or irregular heartbeat
  16. tremors
  17. vomiting, profuse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Acid or sour stomach
  2. belching
  3. body aches or pain
  4. ear congestion
  5. feeling unusually cold, shivering
  6. headache
  7. heartburn
  8. indigestion
  9. loss of voice
  10. nasal congestion
  11. runny nose
  12. sleeplessness
  13. sneezing
  14. stomach discomfort, upset, or pain
  15. trouble sleeping
  16. unable to sleep
  17. weight loss

Less common

  1. Bad, unusual, or unpleasant (after) taste
  2. bloated or full feeling
  3. bloody nose
  4. burning while urinating
  5. change in taste
  6. congestion
  7. cracked lips
  8. dryness or soreness of the throat
  9. excess air or gas in stomach or intestines
  10. feeling of warmth
  11. hair loss
  12. passing gas
  13. rapid weight gain
  14. redness of the face, neck, arms, and occasionally upper chest
  15. tender, swollen glands in the neck
  16. thinning of the hair
  17. unusual tearing of the eyes
  18. voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.