Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Eloxatin


Oxaliplatin injection is given along with other medicines to treat advanced cancer of the colon or rectum. It is also used to treat severe colon cancer in patients who have had a surgery.

Oxaliplatin belongs to the group of medicines called antineoplastics. It interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Some of these may be serious and must be reported to your doctor. Other effects may not be serious but may cause concern. Some effects may occur after treatment with oxaliplatin has been stopped. Be sure that you have discussed with your doctor the possible side effects of this medicine as well as the benefits it can do.

This medicine is to be given only by or under the direct supervision of a doctor.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, oxaliplatin is used in certain patients with the following medical conditions:

  • Colon cancer, stage II, adjuvant treatment in combination with 5-fluorouracil/leucovorin.
  • Gastric carcinoma, advanced or metastatic.
  • Metastatic colorectal cancer (cancer of the colon or rectum that has spread to other areas of the body), first-line therapy, in combination with bevacizumab and capecitabine.
  • Metastatic pancreatic adenocarcinoma (cancer of the pancreas that has spread to other areas of the body), first-line treatment, in combination with 5-fluorouracil, leucovorin, and irinotecan.

This product is available in the following dosage forms:

  • Solution
  • Powder for Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of oxaliplatin injection in the pediatric population. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of oxaliplatin injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution in patients receiving oxaliplatin injection.


Information about this oxaliplatin-intravenous-route
Pregnancy Category Explanation
All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Rotavirus Vaccine, Live

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adenovirus Vaccine Type 4, Live
  • Adenovirus Vaccine Type 7, Live
  • Bacillus of Calmette and Guerin Vaccine, Live
  • Bupropion
  • Cobicistat
  • Dasabuvir
  • Influenza Virus Vaccine, Live
  • Measles Virus Vaccine, Live
  • Mumps Virus Vaccine, Live
  • Poliovirus Vaccine, Live
  • Rubella Virus Vaccine, Live
  • Smallpox Vaccine
  • Typhoid Vaccine
  • Varicella Virus Vaccine
  • Yellow Fever Vaccine

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Congestive heart failure or
  • Heart rhythm problems (eg, slow heartbeat) or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood)—ECG monitoring is recommended in patients with these conditions.
  • Heart rhythm problems (eg, long QT syndrome), family history of—Use is not recommended in patients with this condition.
  • Kidney disease—Effects of oxaliplatin may be increased because of slower removal from the body.
  • Liver disease or
  • Lung disease or
  • Peripheral neuropathy (nerve problem)—Use with caution. May make these conditions worse.

Proper Use

This medicine often causes nausea and vomiting. However, it is very important that you continue to receive this medicine even if you begin to feel ill. Other medicines may be given to you to help with the nausea and vomiting. Ask your doctor for other ways to lessen these effects.

You will receive this medicine while you are in a hospital or cancer treatment center. A doctor or other trained health professional will give you this medicine. This medicine is given through a needle placed into one of your veins.

If any of this medicine gets on your skin or in your eyes, nose, or mouth, tell your doctor or nurse right away.

Oxaliplatin is usually used with other medicines to treat cancer. This combination of medicines is usually given for 2 days, but you will receive oxaliplatin on the first day only (day 1). This 2-day treatment is given again every 14 days until your body responds to the medicine.

This medicine comes with a patient information leaflet. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.


It is very important that your doctor check your progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Make sure your doctor knows if you are pregnant before you receive this medicine. Using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away.

This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, diarrhea, a fever or chills, hives, hoarseness, itching, lightheadedness or dizziness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you receive the medicine.

While you are being treated with oxaliplatin, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Oxaliplatin may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have taken oral polio vaccine within the last several months. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth.

Oxaliplatin can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination.

Check with your doctor right away if you start having cough, shortness of breath, or any problems with breathing. These may be signs of a serious lung disease.

Check with your doctor right away if you are having burning, numbness, tingling, or painful sensations in the arms, hands, legs, or feet. These could be symptoms of a condition called peripheral or sensory neuropathy.

Avoid cold drinks, and the use of ice cubes in drinks. Avoid cold temperatures and cold objects. Cover your skin if you must go outside in cold temperatures. Do not put ice or ice packs on your body. Do not breathe deeply when exposed to cold air. Do not take things from the freezer or refrigerator without wearing gloves. Do not run the air conditioner at high levels in the house or in the car in hot weather.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation.

Rhabdomyolysis may occur while you are using this medicine. Check with your doctor right away if you have dark urine, fever, muscle cramps or spasms, muscle pain or stiffness, or unusual tiredness or weakness.

This medicine may cause blurred vision or other vision problems. If any of these occur, do not drive, use machines, or do anything else that could be dangerous if you are not able to see well. If these reactions are especially bothersome, check with your doctor.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

  1. Abnormal tongue sensation
  2. black, tarry stools
  3. bleeding gums
  4. blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet
  5. blood in the urine or stools
  6. burning, prickling, itching, or tingling of the skin
  7. chest pain
  8. chills
  9. cough
  10. decreased feeling, or pain in the hands, feet, around the mouth, or throat
  11. decreased urination
  12. difficulty performing daily activities such as writing, buttoning, swallowing, or walking
  13. difficulty with articulating words
  14. difficulty with breathing
  15. difficulty with moving
  16. difficulty with swallowing
  17. dizziness
  18. dry mouth
  19. eye pain
  20. fainting
  21. fever
  22. increase in heart rate
  23. jaw spasm
  24. lightheadedness
  25. muscle pain or stiffness
  26. numbness
  27. numbness, pain, tingling, or unusual sensations in the palms of the hands or bottoms of the feet
  28. pain in the chest, groin, or legs, especially the calves
  29. pain in the joints
  30. painful or difficult urination
  31. pale skin
  32. pinpoint red spots on the skin
  33. rapid breathing
  34. sensation of pins and needles
  35. sore throat
  36. sores, ulcers, or white spots on the lips or in the mouth
  37. stabbing pain
  38. sunken eyes
  39. swelling
  40. swelling or inflammation of the mouth
  41. swollen glands
  42. thirst
  43. troubled breathing with exertion
  44. unusual tiredness or weakness
  45. vision changes
  46. wrinkled skin

Less common

  1. Fast heartbeat
  2. hives, itching, or skin rash
  3. increased thirst
  4. irregular heartbeat
  5. loss of appetite
  6. mood changes
  7. nausea or vomiting
  8. numbness or tingling in the hands, feet, or lips
  9. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  10. tightness in the chest

Incidence not known

  1. Back, leg, or stomach pains
  2. blindness
  3. bloated abdomen
  4. blue-yellow color blindness
  5. blurred vision
  6. changes in patterns and rhythms of speech
  7. dark urine
  8. deafness
  9. decreased vision
  10. deep breathing
  11. drowsiness
  12. electric shock-like sensation that moves down the back and into the legs following a bending movement of the neck
  13. general body swelling
  14. increased urination
  15. irregular heartbeat, recurrent
  16. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  17. loss of deep tendon reflexes
  18. muscle cramps or spasms
  19. muscle tremors
  20. pain and fullness in the right upper abdomen
  21. restlessness
  22. severe constipation
  23. severe diarrhea
  24. severe nosebleeds
  25. severe stomach cramps or tenderness
  26. severe vomiting
  27. trouble with speaking
  28. twitches of the muscle visible under the skin
  29. weakness of the muscles in your face
  30. weight gain
  31. yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Agitation
  2. coma
  3. cough or hoarseness
  4. diarrhea
  5. disorientation
  6. involuntary, rapid, or rhythmic movement of the eyes
  7. lack of coordination
  8. lack of sensation
  9. lethargy
  10. lower back or side pain
  11. paralysis
  12. respiratory failure
  13. seizures
  14. severe weakness
  15. slow or irregular heartbeat
  16. tremors
  17. vomiting, profuse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Acid or sour stomach
  2. belching
  3. body aches or pain
  4. ear congestion
  5. feeling unusually cold, shivering
  6. headache
  7. heartburn
  8. indigestion
  9. loss of voice
  10. nasal congestion
  11. runny nose
  12. sneezing
  13. stomach discomfort, upset, or pain
  14. trouble sleeping
  15. weight loss

Less common

  1. Bad, unusual, or unpleasant (after) taste
  2. bloated or full feeling
  3. bloody nose
  4. burning while urinating
  5. change in taste
  6. congestion
  7. cracked lips
  8. dryness or soreness of the throat
  9. excess air or gas in stomach or intestines
  10. feeling of warmth
  11. hair loss
  12. passing gas
  13. rapid weight gain
  14. redness of the face, neck, arms, and occasionally upper chest
  15. tender, swollen glands in the neck
  16. thinning of the hair
  17. unusual tearing of the eyes
  18. voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.