Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Zegerid


Omeprazole and sodium bicarbonate combination is used to treat certain conditions where there is too much acid in the stomach. It is used to treat gastric and duodenal ulcers, erosive esophagitis, and gastroesophageal reflux disease (GERD). GERD is a condition where the acid in the stomach washes back up into the esophagus. Sometimes this medicine is used in combination with antibiotics (eg, amoxicillin, clarithromycin) to treat ulcers associated with infection caused by the H. pylori bacteria (germ).

Omeprazole and sodium bicarbonate combination is used to prevent upper gastrointestinal tract bleeding in seriously ill patients.

Omeprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced by the stomach.

Sodium bicarbonate, also known as baking soda, is an antacid. It works by neutralizing the excess acid in the stomach.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Packet
  • Capsule

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Appropriate studies have not been performed on the relationship of age to the effects of omeprazole and sodium bicarbonate combination in children. Safety and efficacy have not been established.


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of omeprazole and sodium bicarbonate combination in the elderly.


Information about this omeprazole-and-sodium-bicarbonate-oral-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Rilpivirine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Amphetamine
  • Atazanavir
  • Bendamustine
  • Bosutinib
  • Cilostazol
  • Citalopram
  • Clopidogrel
  • Clorazepate
  • Clozapine
  • Dabrafenib
  • Dasabuvir
  • Dasatinib
  • Delavirdine
  • Elvitegravir
  • Erlotinib
  • Eslicarbazepine Acetate
  • Gefitinib
  • Indinavir
  • Ketoconazole
  • Ledipasvir
  • Memantine
  • Methotrexate
  • Mycophenolate Mofetil
  • Mycophenolic Acid
  • Nelfinavir
  • Nilotinib
  • Ombitasvir
  • Paritaprevir
  • Pazopanib
  • Ritonavir
  • Saquinavir
  • Tacrolimus
  • Topotecan
  • Vismodegib

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Armodafinil
  • Carbamazepine
  • Cranberry
  • Dasatinib
  • Digoxin
  • Disulfiram
  • Fluconazole
  • Ginkgo Biloba
  • Iron
  • Levothyroxine
  • Raltegravir
  • St John's Wort
  • Tipranavir
  • Triazolam
  • Voriconazole
  • Warfarin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bartter's syndrome (rare kidney problem) or
  • Diarrhea or
  • Hypocalcemia (low calcium in the blood) or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood), history of or
  • Osteoporosis (bone problem) or
  • Respiratory alkalosis (low levels of carbon dioxide in the blood) or
  • Seizures, history of—Use with caution. May make these conditions worse.
  • Liver disease—You may need a dose adjustment. The effects may be increased because of slower removal of the medicine from the body.

Proper Use

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Do not stop taking this medicine if your doctor told you to take it for a specific amount of time, even if you feel better.

This medicine comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions.

This medicine contains sodium (salt). Talk to your doctor before using this medicine if you are on a low-sodium (low-salt) diet or if you have or are at risk for congestive heart failure.

Tell your doctor if you are taking calcium supplements on a regular basis.

Both 20 and 40 milligrams oral suspension packets or capsules contain the same amount of sodium bicarbonate. Do not substitute two 20 milligrams (mg) oral suspension packets or capsules with one 40 mg oral suspension packets or capsules. Talk to your doctor if you have any questions.

Take this medicine on an empty stomach at least 1 hour before a meal. For patients receiving continuous feeding through a tube, feeding should be temporarily stopped about 3 hours before and 1 hour after administration of Zegerid® powder for oral suspension.

Swallow the capsules whole with water. Do not take it with other liquids. Do not break, crush, or chew it. Do not open the capsule and sprinkle the contents into food.

To use the powder for oral suspension:

  • Empty packet of powder into a small cup containing 1 to 2 tablespoons of water.
  • Do not use other liquids or foods.
  • Stir well and drink immediately.
  • Refill cup with water and drink.

If you are using the powder for oral suspension with a nasogastric or orogastric tube:

  • Mix the packet of powder with approximately 20 mL of water.
  • Stir well and draw up into appropriately sized syringe.
  • Give the medicine through the nasogastric or orogastric tube into the stomach right away.
  • Refill the syringe with an equal amount of water.
  • Shake and flush any remaining contents from the nasogastric or orogastric tube into the stomach.


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (capsules or powder for suspension):
    • To treat duodenal ulcers, erosive esophagitis, and GERD:
      • Adults—20 milligrams (mg) once a day at least 1 hour before a meal. Your doctor may adjust your dose if needed.
      • Children—Use and dose must be determined by your doctor.
    • To treat gastric ulcers:
      • Adults—40 milligrams (mg) once a day at least 1 hour before a meal. Your doctor may adjust your dose if needed.
      • Children—Use and dose must be determined by your doctor.
  • For oral dosage form (powder for suspension):
    • To prevent upper gastrointestinal tract bleeding in seriously ill patients:
      • Adults—The first day: 40 milligrams (mg) for the first dose; then after 6 to 8 hours, a second 40 mg dose. After the first day: 40 mg once a day for up to 14 days.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.


It is important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood, urine, and other laboratory tests may be needed to check for unwanted effects. If your condition does not improve, or if it becomes worse, check with your doctor.

Tell your doctor if you have Asian relatives, such as Filipino, Chinese, Japanese, Korean, or Taiwanese. You may need a lower dose of this medicine to treat erosive esophagitis.

This medicine is sometimes given together with other medicines to treat ulcers. Be sure you understand about the risks and proper use of any other medicine your doctor gives you together with omeprazole and sodium bicarbonate combination.

Atrophic gastritis (inflammation in the stomach) may occur, especially if you take this medicine for a long time. Talk with your doctor if you have concerns about this.

Check with your doctor right away if you or your child have a fever, joint pain, skin rash, swelling of the body, feet, or ankles, or unusual weight gain after receiving this medicine. These could be symptoms of acute interstitial nephritis.

Taking this medicine for a long time may make it harder for your body to absorb vitamin B12. Tell your doctor if you or your child have concerns about vitamin B12 deficiency.

Check with your doctor right away if you have watery stool that does not go away, stomach pain, and fever while taking this medicine.

This medicine may increase your risk of having fractures of the hip, wrist, and spine. This is more likely if you receive high doses of this medicine or use it for one year or more.

This medicine may cause hypomagnesemia (low magnesium in the blood). This is more likely to occur if you are taking this medicine for more than one year, or if you are taking this medicine together with digoxin (Lanoxin®) or certain diuretics or "water pills". Check with your doctor right away if you have convulsions (seizures), fast, racing, or uneven heartbeat, muscle spasms (tetany), tremors, or unusual tiredness or weakness.

Do not stop taking this medicine without first checking with your doctor, or unless told to do so by your doctor.

Make sure any doctor or dentist who treats you knows that you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription (eg, atazanavir, nelfinavir, Reyataz®, Viracept®) or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St John's wort) or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

  1. Black, tarry stools
  2. bleeding gums
  3. blood in the urine or stools
  4. blurred vision
  5. chest pain
  6. confusion
  7. convulsions
  8. cough
  9. decreased urine
  10. dizziness
  11. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  12. drowsiness
  13. dry mouth
  14. fainting
  15. fast or irregular heartbeat
  16. fever or chills
  17. headache
  18. increased thirst
  19. lightheadedness
  20. loss of appetite
  21. mood or mental changes
  22. muscle pain or cramps
  23. muscle spasms (tetany) or twitching
  24. nausea or vomiting
  25. nervousness
  26. numbness or tingling in the hands, feet, or lips
  27. pale skin
  28. pinpoint red spots on the skin
  29. pounding in the ears
  30. rapid, shallow breathing
  31. seizures
  32. slow heartbeat
  33. sneezing
  34. sore throat
  35. sweating
  36. tightness in the chest
  37. trembling
  38. troubled breathing
  39. troubled breathing with exertion
  40. unusual bleeding or bruising
  41. unusual tiredness or weakness

Less common

  1. Abdominal or stomach cramps or pain
  2. bladder pain
  3. blue lips, fingernails, or skin
  4. bone pain
  5. chest discomfort
  6. cloudy urine
  7. coma
  8. decreased urine output
  9. difficult or troubled breathing
  10. difficult, burning, or painful urination
  11. fast, pounding, or irregular heartbeat or pulse
  12. frequent urge to urinate
  13. headache
  14. irregular, fast or slow, or shallow breathing
  15. irritability
  16. lower back or side pain
  17. muscle cramps in the hands, arms, feet, legs, or face
  18. restlessness
  19. swelling
  20. swelling of the face, feet, lower legs, ankles, or hands
  21. weakness or heaviness of the legs


  1. Severe pain in the chest
  2. sudden onset of severe breathing difficulty

Incidence not known

  1. Arm, back, or jaw pain
  2. blistering, peeling, or loosening of the skin
  3. bloating or swelling of the face, arms, hands, lower legs, or feet
  4. chest tightness or heaviness
  5. constipation
  6. cough or hoarseness
  7. dark-colored urine
  8. diarrhea
  9. difficulty with swallowing
  10. fever with or without chills
  11. general body swelling
  12. general feeling of tiredness or weakness
  13. greatly decreased frequency of urination or amount of urine
  14. high fever
  15. hives or skin rash
  16. indigestion
  17. joint or muscle pain
  18. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  19. light-colored stools
  20. noisy breathing
  21. nosebleeds
  22. pain with swallowing
  23. pains in the stomach, side, or abdomen, possibly radiating to the back
  24. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  25. rapid weight gain
  26. red skin lesions, often with a purple center
  27. red, irritated eyes
  28. sores, ulcers, or white spots on the lips or in the mouth
  29. stomach pain, continuing
  30. sweating
  31. swollen glands
  32. unexplained bleeding or bruising
  33. unusual weight gain or loss
  34. weight gain
  35. yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

  1. Feeling of warmth
  2. increased sweating
  3. redness of the face, neck, arms, and occasionally, upper chest

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  1. Agitation
  2. anxiety
  3. cold sweats
  4. cool, pale skin
  5. depression
  6. excess air or gas in the stomach or intestines
  7. flushed, dry skin
  8. fruit-like breath odor
  9. full feeling
  10. increased hunger
  11. increased thirst
  12. increased urination
  13. lack or loss of strength
  14. nightmares
  15. passing gas
  16. shakiness
  17. slurred speech
  18. white patches in the mouth or throat or on the tongue
  19. white patches with diaper rash

Incidence not known

  1. Abnormal dreams
  2. attack, assault, or force
  3. bad, unusual, or unpleasant (after) taste
  4. blindness
  5. blue-yellow color blindness
  6. change in taste
  7. continuing ringing or buzzing or other unexplained noise in the ears
  8. decreased vision
  9. double vision
  10. dry eyes or skin
  11. eye pain
  12. feeling of constant movement of self or surroundings
  13. general feeling of discomfort or illness
  14. hair loss or thinning of the hair
  15. hearing loss
  16. hives or welts
  17. increased sensitivity of the skin to sunlight
  18. itching, redness, tearing, or other sign of eye irritation not present before use of this medicine or becoming worse during use
  19. lack of feeling or emotion
  20. pain in the testes
  21. pinpoint red or purple spots on the skin
  22. redness or other discoloration of the skin
  23. seeing, hearing, or feeling things that are not there
  24. sensation of spinning
  25. severe sunburn
  26. sleepiness or unusual drowsiness
  27. sugar in the urine
  28. swelling of the breasts or breast soreness in both females and males
  29. swelling or inflammation of the mouth
  30. trouble sleeping
  31. uncaring

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.