Interactions

Interactions with Drugs

Omega-3 may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants (blood thinners) such as warfarin (Coumadin®) or heparin, antiplatelet drugs such as clopidogrel (Plavix®), and nonsteroidal anti-inflammatory drugs such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).

Omega-3 may affect blood sugar levels. Caution is advised when using medications that may also affect blood sugar. People taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.

Omega-3 may cause low blood pressure. Caution is advised in people taking drugs that lower blood pressure.

Omega-3 may also interact with agents that may affect the immune system, agents that may affect the nervous system, agents that may be toxic to the liver, agents that may treat abnormal heart rhythms, agents that may treat arthritis, agents that may treat asthma, agents that may treat gout, agents that may treat heart disorders, agents that may treat retrovirus infections (HIV), antiallergic agents, antiandrogens, anticancer agents, antidepressants (SSRIs), antiestrogens, anti-inflammatories, antipsychotics, aspirin, bone agents, cholesterol-lowering agents, cyclosporine, dexamethasone, eye agents, hormonal agents, paclitaxel, skin agents, and stomach agents.

Interactions with Herbs and Dietary Supplements

Omega-3 may increase the risk of bleeding when taken with herbs and supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Omega-3 may affect blood sugar levels. Caution is advised when using herbs or supplements that may also affect blood sugar. Blood glucose levels may require monitoring, and doses may need adjustment.

Omega-3 may cause low blood pressure. Caution is advised in people taking herbs or supplements that lower blood pressure.

Omega-3 may also interact with antiallergic agents, antiandrogens, anticancer herbs and supplements, antidepressants (SSRIs), antiestrogens, anti-inflammatories, antioxidants, antipsychotics, bone agents, cholesterol-lowering herbs and supplements, conjugated linoleic acid, evening primrose oil, fat-soluble vitamins, folate, gamma-linolenic acid, glucosamine, herbs and supplements that may affect the immune system, herbs and supplements that may affect the nervous system, herbs and supplements that may be toxic to the liver, herbs and supplements that may treat abnormal heart rhythms, herbs and supplements that may treat arthritis, herbs and supplements that may treat asthma, herbs and supplements that may treat heart disorders, hormonal herbs and supplements, hormone replacement therapy, lycopene, medium-chain triglycerides, phosphatidylserine, phytosterols, policosanol, selenium, skin agents, stomach agents, and vitamin E.

This evidence-based monograph was prepared by The Natural Standard Research Collaboration

www.naturalstandard.com