Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Floxin

Descriptions


Ofloxacin is used to treat certain bacterial infections in many different parts of the body. It may also be used for other problems as determined by your doctor. Ofloxacin may mask or delay the symptoms of syphilis. It is not effective against syphilis infections.

Ofloxacin belongs to the class of drugs known as fluoroquinolone antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of ofloxacin in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ofloxacin in the elderly. However, elderly patients are more likely to have age-related heart or kidney problems, or develop severe tendon problems (including tendon rupture), which may require caution and an adjustment in the dose for patients receiving ofloxacin.

Pregnancy

Information about this ofloxacin-oral-route
Pregnancy Category Explanation
All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Cisapride
  • Dronedarone
  • Mesoridazine
  • Pimozide
  • Sparfloxacin
  • Thioridazine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acarbose
  • Acecainide
  • Acetohexamide
  • Alfuzosin
  • Alosetron
  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Apomorphine
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Azimilide
  • Azithromycin
  • Bedaquiline
  • Benfluorex
  • Bretylium
  • Chloroquine
  • Chlorpromazine
  • Chlorpropamide
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Crizotinib
  • Dasatinib
  • Desipramine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Droperidol
  • Erythromycin
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Gatifloxacin
  • Gemifloxacin
  • Gliclazide
  • Glimepiride
  • Glipizide
  • Gliquidone
  • Glyburide
  • Granisetron
  • Guar Gum
  • Halofantrine
  • Haloperidol
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Insulin
  • Insulin Aspart, Recombinant
  • Insulin Glulisine
  • Insulin Lispro, Recombinant
  • Lapatinib
  • Levofloxacin
  • Lopinavir
  • Lumefantrine
  • Mefloquine
  • Metformin
  • Methadone
  • Mifepristone
  • Miglitol
  • Moricizine
  • Moxifloxacin
  • Nilotinib
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ondansetron
  • Paliperidone
  • Pazopanib
  • Perflutren Lipid Microsphere
  • Posaconazole
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Salmeterol
  • Saquinavir
  • Sematilide
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sunitinib
  • Tedisamil
  • Telithromycin
  • Tetrabenazine
  • Tizanidine
  • Tolazamide
  • Tolbutamide
  • Toremifene
  • Trifluoperazine
  • Trimipramine
  • Troglitazone
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Vilanterol
  • Vinflunine
  • Voriconazole
  • Warfarin
  • Ziprasidone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Betamethasone
  • Corticotropin
  • Cortisone
  • Cosyntropin
  • Deflazacort
  • Dexamethasone
  • Didanosine
  • Fludrocortisone
  • Fluocortolone
  • Hydrocortisone
  • Iron
  • Methylprednisolone
  • Paramethasone
  • Prednisolone
  • Prednisone
  • Sucralfate
  • Triamcinolone
  • Zinc

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Bradycardia (slow heartbeat) or
  • Diabetes or
  • Diarrhea or
  • Heart disease or
  • Heart rhythm problems (eg, prolonged QT interval), or family history of or
  • Hypokalemia (low potassium in the blood), uncorrected or
  • Myocardial ischemia (reduced blood supply in the heart) or
  • Seizures (epilepsy), or history of—Use with caution. May make these conditions worse.
  • Brain disease (eg, hardening of the arteries) or
  • Kidney disease or
  • Liver disease (including cirrhosis) or
  • Organ transplant (eg, heart, kidney, or lung), history of or
  • Tendon disorder (eg, rheumatoid arthritis), history of—Use with caution. May cause side effects to become worse.
  • Myasthenia gravis (severe muscle weakness), or history of—Should not be used in patients with this condition.

Proper Use

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

You may take this medicine with or without food.

Drink plenty of fluids while you are being treated with this medicine. Drinking extra water will help to prevent some unwanted effects of ofloxacin.

If you are also using antacids containing aluminum or magnesium (such as Maalox®, Mylanta®), multivitamins (with calcium, iron, or zinc), didanosine (Videx®), or sucralfate (Carafate®), take these medicines at least 2 hours before or 2 hours after you take ofloxacin. These medicines may keep ofloxacin from working properly.

Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • For treatment of infection:
      • Adults—200 to 400 milligrams (mg) every twelve hours for 3 to 14 days, depending on the medical problem being treated. Prostatitis is usually treated for six weeks. Gonorrhea is usually treated with a single oral dose of 400 mg.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress while you are using this medicine. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects.

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

This medicine may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor or nurse right away if you have a rash, itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you take this medicine.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loosening of the skin; red skin lesions; severe acne or skin rash; sores or ulcers on the skin; or fever or chills while you are using this medicine.

Check with your doctor right away if you have dark urine, clay-colored stools, abdominal or stomach pain, or yellow eyes or skin. These maybe symptoms of a serious liver problem.

Ofloxacin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.

Tell your doctor right away if you start having numbness, tingling, or burning pain in your hands, arms, legs, or feet. These may be symptoms of a condition called peripheral neuropathy.

Ofloxacin may rarely cause inflammation or even tearing of a tendon (the cord that attaches muscles to bones). The risk of having tendon problems may be increased if you are over 60 years of age, using steroid medicines (eg, dexamethasone, prednisolone, prednisone, or Medrol®), have severe kidney problems, have a history of tendon problems (eg, rheumatoid arthritis), or have received an organ (eg, heart, kidney, or lung) transplant. If you get sudden pain or swelling in a tendon after exercise (eg, in the ankle, back of the knee or leg, shoulder, elbow, or wrist), check with your doctor right away. Refrain from exercise until your doctor says otherwise.

For patients with an abnormally slow heartbeat or low potassium levels in the blood, ofloxacin may increase your risk of having a fast, slow, or irregular heartbeat. Call your doctor right away if you feel that your heart is not beating normally.

Some people who take ofloxacin may become more sensitive to sunlight than they are normally. Exposure to sunlight, even for brief periods of time, may cause severe sunburn, or skin rash, redness, itching, or discoloration. When you begin using this medicine:

  • Stay out of direct sunlight, especially between the hours of 10:00 AM and 3:00 PM, if possible.
  • Wear protective clothing, including a hat and sunglasses.
  • Apply a sun block product that has a sun protection factor (SPF) of at least 15. Some people may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your doctor.
  • Do not use a sun lamp or tanning bed or booth.

If you have a severe reaction from the sun, check with your doctor.

Ofloxacin may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert. If these reactions are especially bothersome, check with your doctor.

For diabetic patients taking insulin or oral medicine: Ofloxacin may cause hypoglycemia (low blood sugar) in some patients. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out). Different people may feel different symptoms of low blood sugar. If you experience symptoms of low blood sugar, stop taking ofloxacin and check with your doctor right away:

  • Symptoms of low blood sugar can include: Anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in concentrating, drowsiness, excessive hunger, headache, nausea, nervousness, rapid heartbeat, shakiness, or unusual tiredness or weakness.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

  1. Abdominal or stomach pain
  2. anxiety
  3. black, tarry stools
  4. bleeding gums
  5. blood in the urine or stools
  6. blurred vision
  7. body aches or pain
  8. chest pain
  9. chills
  10. cloudy urine
  11. cold sweats
  12. coma
  13. confusion
  14. congestion
  15. cool, pale skin
  16. cough
  17. depression
  18. diarrhea
  19. dry mouth
  20. dryness or soreness of the throat
  21. eye pain
  22. fast heartbeat
  23. fever
  24. flushed, dry skin
  25. fruit-like breath odor
  26. general feeling of illness
  27. headache
  28. hoarseness
  29. increased hunger
  30. increased thirst
  31. increased urination
  32. lower back or side pain
  33. nausea
  34. nervousness
  35. nightmares
  36. painful or difficult urination
  37. pale skin
  38. pinpoint red spots on the skin
  39. pus in the urine
  40. runny nose
  41. seizures
  42. shakiness
  43. shortness of breath
  44. slurred speech
  45. sore throat
  46. sores, ulcers, or white spots on the lips or in the mouth
  47. sweating
  48. swollen glands
  49. tender, swollen glands in the neck
  50. trouble with swallowing
  51. troubled breathing with exertion
  52. unexplained weight loss
  53. unusual bleeding or bruising
  54. unusual tiredness or weakness
  55. voice changes
  56. vomiting

Rare

  1. Burning while urinating
  2. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  3. change in color vision
  4. continuing ringing or buzzing or other unexplained noise in the ears
  5. convulsions
  6. decrease in frequency of urination
  7. decrease in urine volume
  8. decreased hearing or any change in hearing
  9. difficult or painful urination
  10. difficulty in passing urine (dribbling)
  11. difficulty seeing at night
  12. difficulty with moving
  13. discouragement
  14. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  15. false or unusual sense of well-being
  16. fast, irregular, pounding, or racing heartbeat or pulse
  17. fear or nervousness
  18. feeling of constant movement of self or surroundings
  19. feeling of warmth or heat
  20. feeling sad or empty
  21. flushing or redness of the skin, especially on the face and neck
  22. hearing loss
  23. hives or welts
  24. increased need to urinate
  25. increased sensitivity of the eyes to sunlight
  26. increased sweating
  27. irritability
  28. itching
  29. joint pain
  30. lack of appetite
  31. large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  32. loss of bladder control
  33. loss of interest or pleasure
  34. muscle aching or cramping
  35. muscle pains or stiffness
  36. muscle spasm or jerking of all extremities
  37. no blood pressure or pulse
  38. no breathing
  39. passing urine more often
  40. pounding in the ears
  41. redness, soreness, or itching skin
  42. seeing, hearing, or feeling things that are not there
  43. sensation of spinning
  44. shakiness in the legs, arms, hands, or feet
  45. skin rash
  46. slow or fast heartbeat
  47. sores, welting, or blisters
  48. stopping of the heart
  49. sudden loss of consciousness
  50. swelling
  51. swollen joints
  52. trembling or shaking of the hands or feet
  53. trouble concentrating
  54. trouble performing routine tasks
  55. trouble sleeping
  56. unconsciousness

Incidence not known

  1. Abdominal or stomach tenderness
  2. actions that are out of control
  3. back, leg, or stomach pains
  4. blistering, peeling, or loosening of the skin
  5. bloating
  6. blue lips and fingernails
  7. burning, dry, or itching eyes
  8. changes in behavior
  9. confusion about identity, place, and time
  10. coughing that sometimes produces a pink frothy sputum
  11. coughing up blood
  12. cracks in the skin
  13. crying
  14. dark-colored urine
  15. darkening of the skin
  16. delusions of persecution, mistrust, suspiciousness, and/or combativeness
  17. depersonalization
  18. diarrhea, watery and severe, which may also be bloody
  19. difficulty with breathing, chewing, or talking
  20. difficulty with speaking
  21. difficulty with swallowing
  22. discharge or excessive tearing
  23. double vision
  24. drooling
  25. drooping eyelids
  26. dysphoria
  27. euphoria
  28. feeling of discomfort
  29. general body swelling
  30. heartburn
  31. high fever
  32. hyperventilation
  33. increased blood pressure
  34. increased menstrual flow or vaginal bleeding
  35. increased sensitivity of the skin to sunlight
  36. increased sweating
  37. indigestion
  38. inflammation of the joints
  39. irregular heartbeats
  40. irregular or slow heart rate
  41. itching of the vagina or outside the genitals
  42. loss of ability to use or understand speech or language
  43. loss of appetite
  44. loss of balance control
  45. loss of heat from the body
  46. mental depression
  47. mood or mental changes
  48. muscle weakness
  49. noisy breathing
  50. nosebleeds
  51. numbness of the hands
  52. pain during sexual intercourse
  53. pain in the ankles or knees
  54. pain, inflammation, or swelling in the calves, shoulders, or hands
  55. painful, red lumps under the skin, mostly on the legs
  56. paralysis
  57. prolonged bleeding from cuts
  58. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  59. quick to react or overreact emotionally
  60. rapidly changing moods
  61. rash
  62. red or black, tarry stools
  63. red or dark brown urine
  64. red skin lesions, often with a purple center
  65. red, irritated eyes
  66. red, swollen skin
  67. redness or other discoloration of the skin
  68. redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  69. restlessness
  70. scaly skin
  71. severe abdominal pain, cramping, or burning
  72. severe sunburn
  73. severe tiredness
  74. shaking
  75. shuffling walk
  76. stiffness of the limbs
  77. stomach pain, continuing
  78. swelling of the face, fingers, or lower legs
  79. swollen lymph glands
  80. talking, feeling, and acting with excitement
  81. thick, white, curd-like vaginal discharge without odor or with mild odor
  82. thoughts of killing oneself
  83. twisting movements of the body
  84. uncontrolled eye movements
  85. uncontrolled movements, especially of the face, neck, and back
  86. unexplained bleeding or bruising
  87. unpleasant breath odor
  88. unsteadiness or awkwardness
  89. unusual behavior, such as disorientation to time or place, failure to recognize people, hyperactivity, or restlessness, especially in children using 2% cyclopentolate
  90. unusual weight loss
  91. upper right abdominal pain
  92. vomiting of blood or material that looks like coffee grounds
  93. weakness in the arms, hands, legs, or feet
  94. weight gain
  95. wheezing
  96. yellowing of the eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  1. Sleeplessness
  2. unable to sleep

Less common

  1. Change in taste
  2. excess air or gas in the stomach or intestines
  3. full feeling
  4. loss of taste
  5. passing gas
  6. runny nose

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.