Description and Brand Names

Drug information provided by: Micromedex

US Brand Name

  1. Aventyl
  2. Pamelor

Descriptions


Nortriptyline is used to treat depression. It is thought to work by increasing the activity of serotonin in the brain. Nortriptyline is a tricyclic antidepressant.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet
  • Capsule
  • Solution

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nortriptyline in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nortriptyline in the elderly. However, elderly patients are more likely to have age-related heart or liver problems, which may require an adjustment in the dose for patients receiving nortriptyline. .

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bepridil
  • Cisapride
  • Dronedarone
  • Furazolidone
  • Grepafloxacin
  • Iproniazid
  • Isocarboxazid
  • Levomethadyl
  • Linezolid
  • Mesoridazine
  • Methylene Blue
  • Metoclopramide
  • Moclobemide
  • Pargyline
  • Phenelzine
  • Pimozide
  • Procarbazine
  • Ranolazine
  • Rasagiline
  • Selegiline
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Tranylcypromine

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Alfuzosin
  • Almotriptan
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amoxapine
  • Amprenavir
  • Apomorphine
  • Aprindine
  • Arsenic Trioxide
  • Asenapine
  • Astemizole
  • Azimilide
  • Azithromycin
  • Bretylium
  • Bupropion
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clonidine
  • Crizotinib
  • Cyclobenzaprine
  • Dasatinib
  • Desipramine
  • Desvenlafaxine
  • Dextromethorphan
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Droperidol
  • Enflurane
  • Epinephrine
  • Erythromycin
  • Etilefrine
  • Fentanyl
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Foscarnet
  • Frovatriptan
  • Gatifloxacin
  • Gemifloxacin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Hydroxytryptophan
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Indacaterol
  • Iobenguane I 123
  • Isoflurane
  • Isradipine
  • Lapatinib
  • Levalbuterol
  • Levofloxacin
  • Levomilnacipran
  • Levothyroxine
  • Lidoflazine
  • Lopinavir
  • Lorcainide
  • Lorcaserin
  • Lumefantrine
  • Mefloquine
  • Methadone
  • Methoxamine
  • Midodrine
  • Mifepristone
  • Moricizine
  • Moxifloxacin
  • Naratriptan
  • Nefopam
  • Nilotinib
  • Norepinephrine
  • Norfloxacin
  • Octreotide
  • Ofloxacin
  • Ondansetron
  • Oxilofrine
  • Paliperidone
  • Pazopanib
  • Pentamidine
  • Perflutren Lipid Microsphere
  • Phenylephrine
  • Posaconazole
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quinidine
  • Quinine
  • Risperidone
  • Saquinavir
  • Sematilide
  • Sertindole
  • Sertraline
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Spiramycin
  • Sulfamethoxazole
  • Sultopride
  • Sunitinib
  • Tapentadol
  • Tedisamil
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Toremifene
  • Tramadol
  • Trazodone
  • Trifluoperazine
  • Trimethoprim
  • Trimipramine
  • Umeclidinium
  • Vardenafil
  • Vasopressin
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Voriconazole
  • Vortioxetine
  • Ziprasidone
  • Zolmitriptan
  • Zotepine

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acenocoumarol
  • Arbutamine
  • Atomoxetine
  • Carbamazepine
  • Cimetidine
  • Dicumarol
  • Paroxetine
  • Phenprocoumon
  • Rifapentine
  • S-Adenosylmethionine
  • Terbinafine
  • Valproic Acid

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Behavior or mood changes (eg, aggression, panic attacks) or
  • Bipolar disorder (mood disorder with mania and depression), or risk of or
  • Glaucoma or
  • Heart rhythm problems (eg, arrhythmia) or
  • Psychosis (mental illness) or
  • Schizophrenia (mental illness) or
  • Seizures, history of or
  • Urinary retention (trouble urinating), history of—Use with caution. May make these conditions worse.
  • Heart attack, recent—Should not be used in patients with this condition.
  • Heart disease or
  • Hyperthyroidism (overactive thyroid)—Use with caution. May cause side effects to become worse.

Proper Use

Take this medicine only as directed by your doctor to benefit your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions.

Measure the oral liquid medicine with a marked measuring spoon, oral syringe, or medicine cup.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (capsules or solution):
    • For depression:
      • Adults—25 milligrams (mg) 3 to 4 times per day. Your doctor may adjust your dose as needed. However, the dose is usually not more than 150 mg per day.
      • Teenagers and older adults—30 to 50 milligrams (mg) once a day or in divided doses during the day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions

It is very important that your doctor check your progress at regular visits to allow for changes in your dose and to check for any unwanted effects.

For some children, teenagers, and young adults, this medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed and have thoughts about hurting yourself. Report any unusual thoughts or behaviors that trouble you, especially if they are new or get worse quickly. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the doctor know if you or anyone in your family has bipolar disorder (manic-depressive) or has tried to commit suicide.

Do not take nortriptyline with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not start taking nortriptyline during the 2 weeks after you stop a MAO inhibitor and wait 2 weeks after stopping nortriptyline before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions.

Nortriptyline may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use nortriptyline with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), linezolid (Zyvox®), lithium (Eskalith®, Lithobid®), methylene blue, tryptophan, St. John's wort, or some pain or migraine medicines (eg, sumatriptan, tramadol, Frova®, Maxalt®, Relpax®, Zomig®). Check with your doctor first before taking any other medicines with nortriptyline.

Do not stop taking this medicine without checking first with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a possible worsening of your condition and reduce the possibility of withdrawal symptoms such as headache, nausea, or a general feeling of discomfort or illness.

This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that cause drowsiness). Some examples of CNS depressants are antihistamines, medicines for hay fever, other allergies or colds; sedatives, tranquilizers, or sleeping medicines; prescription pain medicine or narcotics; medicines for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of these medicines with nortriptyline.

Before having any kind of surgery, tell the medical doctor in charge that you are using this medicine. Taking nortriptyline together with medicines used during surgery may increase the risk of side effects.

This medicine may cause some people to become drowsy. Make sure you know how you react to this medicine before you drive, use medicines, or do anything else that could be dangerous if you are drowsy or not alert.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

  1. Abdominal or stomach pain
  2. agitation
  3. anxiety
  4. black, tarry stools
  5. bleeding and bruising
  6. bleeding gums
  7. blood in the urine or stools
  8. blurred vision
  9. burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  10. chest pain or discomfort
  11. clay-colored stools
  12. cold sweats
  13. confusion about identity, place, and time false beliefs that cannot be changed by facts
  14. continuing ringing or buzzing or other unexplained noise in the ears
  15. convulsions
  16. cool, pale skin
  17. cough or hoarseness
  18. dark urine
  19. decrease in the frequency of urination
  20. decreased urine output or volume
  21. depression
  22. difficulty in passing urine (dribbling)
  23. difficulty in speaking
  24. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  25. double vision
  26. drooling
  27. dry mouth
  28. fast, pounding, or irregular heartbeat or pulse
  29. feeling of warmth
  30. feeling, seeing, or hearing things that are not there
  31. feeling that others are watching you or controlling your behavior
  32. feeling that others can hear your thoughts
  33. fever with or without chills
  34. flushed, dry skin
  35. fruit-like breath odor
  36. general feeling of tiredness or weakness
  37. headache
  38. hearing loss
  39. hostility
  40. hyperventilation
  41. inability to move the arms, legs, or facial muscles
  42. inability to speak
  43. increased hunger
  44. increased need to urinate
  45. increased thirst
  46. increased urination
  47. irritability
  48. itching
  49. lack of coordination
  50. lethargy
  51. loss of appetite
  52. loss of balance control
  53. lower back or side pain
  54. mood or mental changes
  55. muscle spasm or jerking of all extremities
  56. muscle trembling, jerking, or stiffness
  57. muscle twitching
  58. nausea
  59. nightmares
  60. pain or discomfort in the arms, jaw, back, or neck
  61. painful or difficult urination
  62. panic
  63. passing urine more often
  64. perspiration
  65. pinpoint red or purple spots on the skin
  66. pounding in the ears
  67. rapid weight gain
  68. rash
  69. redness of the face, neck, arms, and occasionally, upper chest
  70. restlessness
  71. seizures
  72. shakiness and unsteady walk
  73. shortness of breath
  74. shuffling walk
  75. sleeplessness
  76. slow speech
  77. slurred speech
  78. sore throat
  79. sores, ulcers, or white spots on the lips or in the mouth
  80. stiffness of the limbs
  81. stupor
  82. sudden loss of consciousness
  83. sweating
  84. swelling of the face, ankles, legs, or hands
  85. swollen glands
  86. talking, feeling, and acting with excitement
  87. trouble in holding or releasing urine
  88. trouble sleeping
  89. twisting movements of the body uncontrolled movements, especially of the face, neck, and back
  90. unable to sleep
  91. unpleasant breath odor
  92. unsteadiness, awkwardness, trembling, or other problems with muscle control or coordination
  93. unusual behavior
  94. unusual bleeding or bruising
  95. unusual tiredness or weakness
  96. vomiting of blood
  97. weakness in the arms, hands, legs, or feet
  98. weight gain or loss
  99. yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  1. Abdominal or stomach cramps
  2. bigger, dilated, or enlarged pupils (black part of the eye)
  3. black tongue
  4. bloating
  5. decreased interest in sexual ability or desire
  6. diarrhea
  7. difficulty having a bowel movement (stool)
  8. enlargement of the breast
  9. hair loss or thinning of the hair
  10. heartburn
  11. hives or welts
  12. inability to have or keep an erection
  13. increase in sexual ability or desire
  14. increased sensitivity of the eyes to light
  15. increased sensitivity of the skin to sunlight
  16. increased urge to urinate during the night
  17. loss in sexual ability or desire
  18. pain or discomfort in the chest, upper stomach, or throat
  19. peculiar taste
  20. redness or other discoloration of the skin
  21. severe sunburn
  22. small red or purple spots on the skin
  23. swelling of the testicles
  24. swelling of the breasts or breast soreness in both females and males
  25. swelling or inflammation of the mouth
  26. swollen, painful, or tender lymph glands on side of face or neck
  27. vision changes
  28. waking to urinate at night

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.