Before Using

Drug information provided by: Micromedex

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nilotinib in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nilotinib in the elderly.

Pregnancy

Information about this nilotinib-oral-route
Pregnancy Category Explanation
All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Dronedarone
  • Fluconazole
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Saquinavir
  • Sparfloxacin
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abiraterone Acetate
  • Afatinib
  • Alfuzosin
  • Aliskiren
  • Ambrisentan
  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Apomorphine
  • Aprepitant
  • Arsenic Trioxide
  • Asenapine
  • Atazanavir
  • Azithromycin
  • Bedaquiline
  • Boceprevir
  • Bosutinib
  • Captopril
  • Carbamazepine
  • Carvedilol
  • Chloroquine
  • Chlorpromazine
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clozapine
  • Cobicistat
  • Colchicine
  • Conivaptan
  • Crizotinib
  • Cyclobenzaprine
  • Dabigatran Etexilate
  • Dabrafenib
  • Dasatinib
  • Desipramine
  • Dexamethasone
  • Dexlansoprazole
  • Digoxin
  • Diltiazem
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Droperidol
  • Enzalutamide
  • Erythromycin
  • Eslicarbazepine Acetate
  • Esomeprazole
  • Everolimus
  • Felodipine
  • Fentanyl
  • Fexofenadine
  • Fingolimod
  • Flecainide
  • Fluoxetine
  • Formoterol
  • Fosaprepitant
  • Fosphenytoin
  • Gatifloxacin
  • Gemifloxacin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Ibutilide
  • Iloperidone
  • Imatinib
  • Imipramine
  • Indinavir
  • Itraconazole
  • Ivabradine
  • Ketoconazole
  • Lansoprazole
  • Lapatinib
  • Levofloxacin
  • Loperamide
  • Lopinavir
  • Lumefantrine
  • Methadone
  • Midazolam
  • Mifepristone
  • Moxifloxacin
  • Nefazodone
  • Nelfinavir
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Omeprazole
  • Ondansetron
  • Paliperidone
  • Pantoprazole
  • Pasireotide
  • Pazopanib
  • Perflutren Lipid Microsphere
  • Phenobarbital
  • Phenytoin
  • Pixantrone
  • Pomalidomide
  • Primidone
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propranolol
  • Protriptyline
  • Quercetin
  • Quetiapine
  • Quinidine
  • Quinine
  • Rabeprazole
  • Ranolazine
  • Rifabutin
  • Rifampin
  • Rifapentine
  • Ritonavir
  • Rivaroxaban
  • Romidepsin
  • Salmeterol
  • Saxagliptin
  • Silodosin
  • Simeprevir
  • Sirolimus
  • Sitagliptin
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • St John's Wort
  • Sunitinib
  • Tacrolimus
  • Talinolol
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Terfenadine
  • Tetrabenazine
  • Ticagrelor
  • Tipranavir
  • Tizanidine
  • Tocophersolan
  • Tolvaptan
  • Toremifene
  • Trabectedin
  • Trazodone
  • Trifluoperazine
  • Trimipramine
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Vilanterol
  • Vinblastine
  • Vincristine
  • Vincristine Sulfate Liposome
  • Vinflunine
  • Voriconazole

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • food
  • Grapefruit Juice

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Blood or bone marrow problems (e.g., anemia, neutropenia, thrombocytopenia) or
  • Heart disease or
  • Hyperkalemia (high potassium in the blood) or
  • Hypocalcemia (low calcium in the blood) or
  • Hyponatremia (low sodium in the blood) or
  • Hypophosphatemia (low phosphate in the blood) or
  • Pancreatitis (inflammation of the pancreas), history of—Use with caution. May make these conditions worse.
  • Heart rhythm problems (e.g., long QT syndrome) or
  • Hypokalemia (low potassium in the blood) or
  • Hypomagnesemia (low magnesium in the blood)—Should not be used in patients with these conditions.
  • Lactose intolerance—Use with caution. This medicine contains lactose.
  • Liver disease—Use with caution. The effects may be increased because of slower removal of nilotinib from the body.
  • Total gastrectomy (surgery that involves the removal of the entire stomach)—The effects of nilotinib may be decreased in patients who had this procedure.