Before Using

Drug information provided by: Merative, Micromedex®

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

The use of niacin and lovastatin combination is not recommended in children.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of niacin and lovastatin combination in the elderly.

Breastfeeding

Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amprenavir
  • Atazanavir
  • Boceprevir
  • Clarithromycin
  • Cobicistat
  • Darunavir
  • Erythromycin
  • Fosamprenavir
  • Idelalisib
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Levoketoconazole
  • Lopinavir
  • Mibefradil
  • Mifepristone
  • Nefazodone
  • Nelfinavir
  • Nirmatrelvir
  • Posaconazole
  • Ritonavir
  • Saquinavir
  • Telaprevir
  • Telithromycin
  • Tipranavir
  • Voriconazole

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Adagrasib
  • Amiodarone
  • Atorvastatin
  • Bezafibrate
  • Carbamazepine
  • Ceritinib
  • Cerivastatin
  • Ciprofibrate
  • Clofibrate
  • Colchicine
  • Conivaptan
  • Cyclosporine
  • Dabigatran Etexilate
  • Dabrafenib
  • Dalfopristin
  • Danazol
  • Daptomycin
  • Delavirdine
  • Diltiazem
  • Dronedarone
  • Duvelisib
  • Eltrombopag
  • Fedratinib
  • Fenofibrate
  • Fenofibric Acid
  • Fexinidazole
  • Fluconazole
  • Fosnetupitant
  • Gemfibrozil
  • Glecaprevir
  • Ivosidenib
  • Larotrectinib
  • Lefamulin
  • Lenacapavir
  • Letermovir
  • Levoketoconazole
  • Lomitapide
  • Lorlatinib
  • Lovastatin
  • Lumacaftor
  • Mavacamten
  • Methotrexate
  • Netupitant
  • Niacin
  • Olutasidenib
  • Omaveloxolone
  • Pacritinib
  • Phenobarbital
  • Pibrentasvir
  • Pirtobrutinib
  • Pitavastatin
  • Primidone
  • Quinupristin
  • Ranolazine
  • Ritlecitinib
  • Rosuvastatin
  • Simvastatin
  • Trofinetide
  • Verapamil

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Azithromycin
  • Bosentan
  • Clopidogrel
  • Oat Bran
  • Pectin
  • St John's Wort
  • Warfarin

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Grapefruit Juice

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse, or history of or
  • Liver disease, history of—Use with caution. May cause side effects to become worse.
  • Angina (severe chest pain), unstable or
  • Diabetes or
  • Gout or
  • Heart attack, acute—Use with caution. May make these conditions worse.
  • Bleeding, arterial (coming from an artery) or
  • Liver disease, active or
  • Liver enzymes, elevated or
  • Peptic ulcer disease, active—Should not be used in patients with these conditions.
  • Electrolyte disorders, severe or
  • Endocrine disorders, severe or
  • Epilepsy (seizures), not well-controlled or
  • Hypotension (low blood pressure) or
  • Metabolic disorders, severe or
  • Sepsis (severe infection in the blood)—Patients with these conditions may be at risk of developing muscle and kidney problems.
  • Kidney disease—Use with caution. The effects this medicine may be increased because of slower removal of the medicine from the body.